PDB: 66833 件ウェブページステータス検索Chemie searchBIRD

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2JDL	Structure of C-terminal region of acidic P2 ribosomal protein complexed with trichosanthin 分子名称: ACIDIC RIBOSOMAL PROTEIN P2, RIBOSOME-INACTIVATING PROTEIN ALPHA-TRICHOSANTHIN 著者 Too, P.H, Mak, A.N, Zhu, G, Au, S.W, Wong, K.B, Shaw, P.C. 登録日 2007-01-11 公開日 2008-02-05 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The C-Terminal Fragment of the Ribosomal P Protein Complexed to Trichosanthin Reveals the Interaction between the Ribosome-Inactivating Protein and the Ribosome. Nucleic Acids Res., 37, 2009
7PK4	Tick salivary cystatin Ricistatin in complex with cathepsin V 分子名称: 1,2-ETHANEDIOL, Cathepsin L2, DI(HYDROXYETHYL)ETHER, ... 著者 Busa, M, Mares, M. 登録日 2021-08-25 公開日 2022-12-14 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Protease-bound structure of Ricistatin provides insights into the mechanism of action of tick salivary cystatins in the vertebrate host. Cell.Mol.Life Sci., 80, 2023
7QBN	Structure of cathepsin K in complex with the azadipeptide nitrile inhibitor Gu1303 分子名称: (phenylmethyl) ~{N}-[(2~{S})-1-[[aminomethyl(methyl)amino]-methyl-amino]-1-oxidanylidene-3-phenyl-propan-2-yl]carbamate, ACETATE ION, CHLORIDE ION, ... 著者 Benysek, J, Busa, M, Mares, M. 登録日 2021-11-19 公開日 2022-01-26 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes. J Enzyme Inhib Med Chem, 37, 2022
7QBL	Structure of cathepsin K in complex with the 3-cyano-3-aza-beta-amino acid inhibitor Gu2602 分子名称: Cathepsin K, ~{tert}-butyl ~{N}-[iminomethyl-[2-[methyl-(phenylmethyl)amino]-2-oxidanylidene-ethyl]amino]carbamate 著者 Benysek, J, Busa, M, Mares, M. 登録日 2021-11-19 公開日 2022-01-26 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes. J Enzyme Inhib Med Chem, 37, 2022
7O1E	Crystal structure of PCNA from Chaetomium thermophilum 分子名称: Proliferating cell nuclear antigen 著者 Alphey, M.A, MacNeill, S, Yang, D. 登録日 2021-03-29 公開日 2022-04-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Non-canonical binding of the Chaetomium thermophilum PolD4 N-terminal PIP motif to PCNA involves Q-pocket and compact 2-fork plug interactions but no 3 10 helix. Febs J., 290, 2023
7O1F	PCNA from Chaetomium thermophilum in complex with PolD4 PIP peptide 分子名称: Peptide fragment from PolD4, Proliferating cell nuclear antigen, SODIUM ION 著者 Alphey, M.A, MacNeill, S, Yang, D. 登録日 2021-03-29 公開日 2022-04-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Non-canonical binding of the Chaetomium thermophilum PolD4 N-terminal PIP motif to PCNA involves Q-pocket and compact 2-fork plug interactions but no 3 10 helix. Febs J., 290, 2023
7QGY	Human carbonic anhydrase II in complex with 3-((5-(ethoxycarbonyl)-4-methylthiazol-2-yl)(4-sulfamoylphenyl)amino)propanoic acid 分子名称: 3-[(5-ethoxycarbonyl-4-methyl-1,3-thiazol-2-yl)-(4-sulfamoylphenyl)amino]propanoic acid, Carbonic anhydrase 2, ZINC ION 著者 Paketuryte-Latve, V, Smirnov, A, Manakova, E, Grazulis, S. 登録日 2021-12-10 公開日 2022-05-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Beta and Gamma Amino Acid-Substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases. Pharmaceuticals, 15, 2022
7QPF	Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate 分子名称: 2-(1~{H}-benzimidazol-2-ylsulfanylmethyl)-3-bromanyl-5,7-dimethyl-imidazo[1,2-a]pyrimidine, MAGNESIUM ION, ZINC ION, ... 著者 Leonard, P.M, Langgard, M. 登録日 2022-01-04 公開日 2023-04-19 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate To Be Published
7QPQ	Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate 分子名称: 2-[(1-methyl-4-phenyl-imidazol-2-yl)methylsulfanyl]-[1,2,4]triazolo[1,5-a]pyridine, MAGNESIUM ION, ZINC ION, ... 著者 Leonard, P.M, Langgard, M. 登録日 2022-01-05 公開日 2023-04-19 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate To Be Published
7QQ4	Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate 分子名称: 5,8-dimethyl-2-[2-(1-methyl-4-phenyl-imidazol-2-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrazine, MAGNESIUM ION, ZINC ION, ... 著者 Leonard, P.M, Langgard, M. 登録日 2022-01-06 公開日 2023-04-19 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate To Be Published
7QPM	Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate 分子名称: 5,7-dimethyl-2-[(1-methyl-4-phenyl-imidazol-2-yl)sulfanylmethyl]imidazo[1,2-a]pyrimidine, MAGNESIUM ION, ZINC ION, ... 著者 Leonard, P.M, Langgard, M. 登録日 2022-01-05 公開日 2023-04-19 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate To Be Published
7QPV	Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate 分子名称: 8-methyl-2-[2-(1-methyl-4-phenyl-imidazol-2-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyridine, MAGNESIUM ION, ZINC ION, ... 著者 Leonard, P.M, Langgard, M. 登録日 2022-01-05 公開日 2023-04-19 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate To Be Published
1F9I	CRYSTAL STRUCTURE OF THE PHOTOACTIVE YELLOW PROTEIN MUTANT Y42F 分子名称: 4'-HYDROXYCINNAMIC ACID, PHOTOACTIVE YELLOW PROTEIN 著者 Brudler, R, Meyer, T.E, Genick, U.K, Tollin, G, Getzoff, E.D. 登録日 2000-07-10 公開日 2000-07-21 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Coupling of hydrogen bonding to chromophore conformation and function in photoactive yellow protein. Biochemistry, 39, 2000
3TFB	Transthyretin natural mutant A25T 分子名称: Transthyretin 著者 Azevedo, E.P.C, Pereira, H.M, Garratt, R.C, Kelly, J.W, Foguel, D, Palhano, F.L. 登録日 2011-08-15 公開日 2011-12-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.033 Å) 主引用文献 Dissecting the Structure, Thermodynamic Stability, and Aggregation Properties of the A25T Transthyretin (A25T-TTR) Variant Involved in Leptomeningeal Amyloidosis: Identifying Protein Partners That Co-Aggregate during A25T-TTR Fibrillogenesis in Cerebrospinal Fluid. Biochemistry, 50, 2011
5H2U	Crystal structure of PTK6 Kinase Domain complexed with Dasatinib 分子名称: GLYCEROL, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, Protein-tyrosine kinase 6 著者 Thakur, M.K, Birudukota, S, Swaminathan, S, Tyagi, R, Gosu, R. 登録日 2016-10-18 公開日 2017-01-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Co-crystal structures of PTK6: With Dasatinib at 2.24 angstrom , with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 angstrom resolution Biochem. Biophys. Res. Commun., 482, 2017
5DR5	Crystal structure of the sclerostin-neutralizing Fab AbD09097 分子名称: AbD09097 Fab heavy chain, AbD09097 Fab light chain 著者 Mueller, T.D, Boschert, V, Weidauer, S.E, Muth, E.M, Knappik, A, Frisch, C. 登録日 2015-09-15 公開日 2016-08-31 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Generation and Affinity Maturation of Neutralizing Anti-Sclerostin Antibodies to be published
7SJZ	Crystal structure of aS162A mutant of Co-type nitrile hydratase from Pseudonocardia thermophila 分子名称: Cobalt-containing nitrile hydratase subunit alpha, Cobalt-containing nitrile hydratase subunit beta 著者 Ogutu, R.A.M.I, Holz, C.R, Bennett, B, St Maurice, M. 登録日 2021-10-19 公開日 2021-12-15 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Examination of the Catalytic Role of the Axial Cystine Ligand in the Co-Type Nitrile Hydratase from Pseudonocardia thermophila JCM 3095 Catalysts, 11, 2021
3T50	X-ray structure of the LOV domain from the LOV-HK sensory protein from Brucella abortus (dark state). 分子名称: Blue-light-activated histidine kinase, FLAVIN MONONUCLEOTIDE 著者 Rinaldi, J.J, Klinke, S, Goldbaum, F.A. 登録日 2011-07-26 公開日 2012-06-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.64 Å) 主引用文献 The Beta-Scaffold of the LOV Domain of the Brucella Light-Activated Histidine Kinase Is a Key Element for Signal Transduction J.Mol.Biol., 420, 2012
1F98	CRYSTAL STRUCTURE OF THE PHOTOACTIVE YELLOW PROTEIN MUTANT T50V 分子名称: 4'-HYDROXYCINNAMIC ACID, PHOTOACTIVE YELLOW PROTEIN 著者 Brudler, R, Meyer, T.E, Genick, U.K, Tollin, G, Getzoff, E.D. 登録日 2000-07-07 公開日 2000-07-21 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Coupling of hydrogen bonding to chromophore conformation and function in photoactive yellow protein. Biochemistry, 39, 2000
2QNY	Crystal structure of the complex between the A246F mutant of mycobacterium beta-ketoacyl-acyl carrier protein synthase III (FABH) and SS-(2-hydroxyethyl) O-decyl ester carbono(dithioperoxoic) acid 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 3, BETA-MERCAPTOETHANOL, DECYL FORMATE 著者 Sachdeva, S, Musayev, F, Alhamadsheh, M, Scarsdale, J.N, Wright, H.T, Reynolds, K.A. 登録日 2007-07-19 公開日 2008-05-06 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH Chem.Biol., 15, 2008
2QNX	Crystal structure of the complex between the mycobacterium beta-ketoacyl-acyl carrier protein synthase III (FABH) and 11-[(decyloxycarbonyl)dithio]-undecanoic acid 分子名称: 11-MERCAPTOUNDECANOIC ACID, 3-oxoacyl-[acyl-carrier-protein] synthase 3, O-DECYL HYDROGEN THIOCARBONATE 著者 Sachdeva, S, Musayev, F, Alhamadsheh, M, Scarsdale, J.N, Wright, H.T, Reynolds, K.A. 登録日 2007-07-19 公開日 2008-05-06 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH Chem.Biol., 15, 2008
2QO1	2.6 Angstrom Crystal Structure of the Complex Between 11-(decyldithiocarbonyloxy)-undecanoic acid and Mycobacterium Tuberculosis FabH. 分子名称: 11-[(MERCAPTOCARBONYL)OXY]UNDECANOIC ACID, 3-oxoacyl-[acyl-carrier-protein] synthase 3, DECANE-1-THIOL 著者 Sachdeva, S, Musayev, F, Alhamadsheh, M, Scarsdale, J.N, Wright, H.T, Reynolds, K.A. 登録日 2007-07-19 公開日 2008-05-06 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH Chem.Biol., 15, 2008
2R61	Crystal structure of the Staphylococcal superantigen-like protein SSL5 in complex with sialyl-Lewis X at pH 7.4 分子名称: CHLORIDE ION, Exotoxin 3, GLYCEROL, ... 著者 Baker, H.M. 登録日 2007-09-05 公開日 2007-11-27 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Crystal structures of the staphylococcal toxin SSL5 in complex with sialyl Lewis X reveal a conserved binding site that shares common features with viral and bacterial sialic acid binding proteins J.Mol.Biol., 374, 2007
3Q8T	Crystal structure of the coiled coil domain of Beclin 1, an essential autophagy protein 分子名称: Beclin-1 著者 Li, X, Zhao, Y. 登録日 2011-01-07 公開日 2012-01-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG Nat Commun, 3, 2012
3IXF	Crystal Structure of Dehaloperoxidase B at 1.58 and Structural Characterization of the AB Dimer from Amphitrite ornata 分子名称: Dehaloperoxidase B, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 de Serrano, V.S, D'Antonio, J, Thompson, M.K, Franzen, S, Ghiladi, R.A. 登録日 2009-09-03 公開日 2010-05-19 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Structure of dehaloperoxidase B at 1.58 A resolution and structural characterization of the AB dimer from Amphitrite ornata. Acta Crystallogr.,Sect.D, 66, 2010

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