5DR5

Crystal structure of the sclerostin-neutralizing Fab AbD09097

Summary for 5DR5

• Entry DOI: 10.2210/pdb5dr5/pdb
• Descriptor: AbD09097 Fab heavy chain, AbD09097 Fab light chain (3 entities in total)
• Functional Keywords: sclerostin-neutralizing, fab, wnt inhibitor, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 50245.71

Authors

Mueller, T.D.,Boschert, V.,Weidauer, S.E.,Muth, E.M.,Knappik, A.,Frisch, C. (deposition date: 2015-09-15, release date: 2016-08-31, Last modification date: 2024-01-10)

• Primary citation: Boschert, V.,Frisch, C.,Back, J.W.,van Pee, K.,Weidauer, S.E.,Muth, E.-M.,Schmieder, P.,Beerbaum, M.,Knappik, A.,Timmerman, P.,Mueller, T.D.; Generation and Affinity Maturation of Neutralizing Anti-Sclerostin Antibodies; to be published,

Experimental method

X-RAY DIFFRACTION (1.85 Å)