5DR5
Crystal structure of the sclerostin-neutralizing Fab AbD09097
Summary for 5DR5
Entry DOI | 10.2210/pdb5dr5/pdb |
Descriptor | AbD09097 Fab heavy chain, AbD09097 Fab light chain (3 entities in total) |
Functional Keywords | sclerostin-neutralizing, fab, wnt inhibitor, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 50245.71 |
Authors | Mueller, T.D.,Boschert, V.,Weidauer, S.E.,Muth, E.M.,Knappik, A.,Frisch, C. (deposition date: 2015-09-15, release date: 2016-08-31, Last modification date: 2024-11-13) |
Primary citation | Boschert, V.,Frisch, C.,Back, J.W.,van Pee, K.,Weidauer, S.E.,Muth, E.-M.,Schmieder, P.,Beerbaum, M.,Knappik, A.,Timmerman, P.,Mueller, T.D. Generation and Affinity Maturation of Neutralizing Anti-Sclerostin Antibodies to be published, |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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