7QQ4

Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate

Summary for 7QQ4

• Entry DOI: 10.2210/pdb7qq4/pdb
• Descriptor: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 5,8-dimethyl-2-[2-(1-methyl-4-phenyl-imidazol-2-yl)ethyl]-[1,2,4]triazolo[1,5-a]pyrazine, ZINC ION, ... (5 entities in total)
• Functional Keywords: phosphodiesterase, pde, pde10a, schizophrenia, basal ganglia disorders, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 80097.29

Authors

Leonard, P.M.,Langgard, M. (deposition date: 2022-01-06, release date: 2023-04-19, Last modification date: 2024-02-07)

• Primary citation: Kehler, J.,Kilburn, J.P.,Langgard, M.,Christoffersen, C.T.,Ritzen, A.,Marigo, M.,Jessing, M.,Bundgaard, C.,Puschl, A.,Feigin, K.,Nielsen, J.; Discovery of Lu AF11167, a Phosphodiesterase 10A inhibitor clinical candidate; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.45 Å)