2QNY
Crystal structure of the complex between the A246F mutant of mycobacterium beta-ketoacyl-acyl carrier protein synthase III (FABH) and SS-(2-hydroxyethyl) O-decyl ester carbono(dithioperoxoic) acid
Summary for 2QNY
Entry DOI | 10.2210/pdb2qny/pdb |
Related | 1HNJ 1HNK 1HZP 1U6E 1U6S 2QNX 2QNZ 2QO0 2QO1 |
Descriptor | 3-oxoacyl-[acyl-carrier-protein] synthase 3, DECYL FORMATE, BETA-MERCAPTOETHANOL, ... (4 entities in total) |
Functional Keywords | fatty acid biosynthesis, myobacterium tuberculosis, structural basis for substrate specificity, enzyme inhibitor complex, mechanism based inhibitor, acyltransferase, lipid synthesis, multifunctional enzyme, transferase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 70565.95 |
Authors | Sachdeva, S.,Musayev, F.,Alhamadsheh, M.,Scarsdale, J.N.,Wright, H.T.,Reynolds, K.A. (deposition date: 2007-07-19, release date: 2008-05-06, Last modification date: 2023-08-30) |
Primary citation | Sachdeva, S.,Musayev, F.N.,Alhamadsheh, M.M.,Scarsdale, J.N.,Wright, H.T.,Reynolds, K.A. Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH Chem.Biol., 15:402-412, 2008 Cited by PubMed: 18420147DOI: 10.1016/j.chembiol.2008.03.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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