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2QO1

2.6 Angstrom Crystal Structure of the Complex Between 11-(decyldithiocarbonyloxy)-undecanoic acid and Mycobacterium Tuberculosis FabH.

Summary for 2QO1
Entry DOI10.2210/pdb2qo1/pdb
Related1HNJ 1HNK 1HZP 1U6E 1U6S 2QNX 2QNY 2QNZ 2QO0
Descriptor3-oxoacyl-[acyl-carrier-protein] synthase 3, 11-[(MERCAPTOCARBONYL)OXY]UNDECANOIC ACID, DECANE-1-THIOL, ... (4 entities in total)
Functional Keywordsfatty acid biosynthesis, myobacterium tuberculosis, structural basis for substrate specificity, enzyme inhibitor complex, mechanism based inhibitor, substrate entry and exit, acyltransferase, lipid synthesis, multifunctional enzyme, transferase
Biological sourceMycobacterium tuberculosis
Total number of polymer chains2
Total formula weight70680.21
Authors
Sachdeva, S.,Musayev, F.,Alhamadsheh, M.,Scarsdale, J.N.,Wright, H.T.,Reynolds, K.A. (deposition date: 2007-07-19, release date: 2008-05-06, Last modification date: 2023-08-30)
Primary citationSachdeva, S.,Musayev, F.N.,Alhamadsheh, M.M.,Scarsdale, J.N.,Wright, H.T.,Reynolds, K.A.
Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH
Chem.Biol., 15:402-412, 2008
Cited by
PubMed: 18420147
DOI: 10.1016/j.chembiol.2008.03.007
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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