PDB: 608 件ウェブページステータス検索Chemie searchBIRD

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1YZ5	The crystal structure of 14-3-3-sigma at 2.8 angstrom resolution 分子名称: 14-3-3 protein sigma 著者 Benzinger, A, Popowicz, G.M, Holak, T.A, Hermeking, H. 登録日 2005-02-28 公開日 2005-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization. Cell Res., 15, 2005
2BTP	14-3-3 Protein Theta (Human) Complexed to Peptide 分子名称: 14-3-3 PROTEIN TAU, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS 著者 Elkins, J.M, Johansson, A.C.E, Smee, C, Yang, X, Sundstrom, M, Edwards, A, Arrowsmith, C, Doyle, D.A, Structural Genomics Consortium (SGC) 登録日 2005-06-05 公開日 2005-06-28 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc.Natl.Acad.Sci.USA, 103, 2006
6TWZ	14-3-3 sigma complexed with a phosphorylated 16E6 peptide 分子名称: 14-3-3 protein sigma, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, D(-)-TARTARIC ACID, ... 著者 Gogl, G, Cousido-Siah, A, Sluchanko, N.N, Trave, G. 登録日 2020-01-13 公開日 2020-05-06 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study. Structure, 28, 2020
6BQT	Complex of 14-3-3 theta with an IRSp53 peptide doubly-phosphorylated at T340 and T360 分子名称: 1,2-ETHANEDIOL, 14-3-3 protein theta, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ... 著者 Kast, D.J, Dominguez, R. 登録日 2017-11-28 公開日 2018-12-05 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Mechanism of IRSp53 inhibition by 14-3-3. Nat Commun, 10, 2019
1A4O	14-3-3 PROTEIN ZETA ISOFORM 分子名称: 14-3-3 PROTEIN ZETA 著者 Liu, D, Bienkowska, J, Petosa, C, Collier, R.J, Fu, H, Liddington, R.C. 登録日 1998-02-01 公開日 1999-03-02 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of the zeta isoform of the 14-3-3 protein. Nature, 376, 1995
6FEL	Structure of 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser511 分子名称: 14-3-3 protein gamma, Calcium/calmodulin-dependent protein kinase kinase 2 著者 Lentini Santo, D, Obsilova, V, Obsil, T. 登録日 2018-01-02 公開日 2018-01-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 14-3-3 protein directly interacts with the kinase domain of calcium/calmodulin-dependent protein kinase kinase (CaMKK2). Biochim. Biophys. Acta, 1862, 2018
6GKG	Structure of 14-3-3 gamma in complex with caspase-2 14-3-3 binding motif Ser164 分子名称: 14-3-3 protein gamma, Caspase-2 著者 Alblova, M, Obsil, T, Obsilova, V. 登録日 2018-05-20 公開日 2018-10-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.847 Å) 主引用文献 14-3-3 protein masks the nuclear localization sequence of caspase-2. FEBS J., 285, 2018
4ZDR	Crystal structure of 14-3-3[zeta]-LKB1 fusion protein 分子名称: 14-3-3 protein zeta/delta,GGSGGS linker,Serine/threonine-protein kinase STK11, GLYCEROL, PROPANE, ... 著者 Ding, S, Shi, Z.B. 登録日 2015-04-18 公開日 2015-09-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.899 Å) 主引用文献 Structure of the 14-3-3 zeta-LKB1 fusion protein provides insight into a novel ligand-binding mode of 14-3-3. Acta Crystallogr.,Sect.F, 71, 2015
6BD2	Complex of 14-3-3 theta with an IRSp53 peptide doubly-phosphorylated at T340 and S366 分子名称: 1,2-ETHANEDIOL, 14-3-3 protein theta, DI(HYDROXYETHYL)ETHER, ... 著者 Kast, D.J, Dominguez, R. 登録日 2017-10-20 公開日 2018-10-24 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Mechanism of IRSp53 inhibition by 14-3-3. Nat Commun, 10, 2019
8AH2	Crystal structure of human 14-3-3 zeta fused to the NPM1 peptide including phosphoserine-48 分子名称: 14-3-3 protein zeta/delta,Nucleophosmin 著者 Boyko, K.M, Kapitonova, A.A, Tugaeva, K.V, Varfolomeeva, L.A, Sluchanko, N.N. 登録日 2022-07-20 公開日 2022-09-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis for the recognition by 14-3-3 proteins of a conditional binding site within the oligomerization domain of human nucleophosmin. Biochem.Biophys.Res.Commun., 627, 2022
6BYJ	Structure of human 14-3-3 gamma bound to O-GlcNAc peptide 分子名称: 14-3-3 protein gamma, 2-acetamido-2-deoxy-beta-D-glucopyranose, TSTTATPPVSQASSTTTSTW O-GlcNac peptide 著者 Schumacher, M.A. 登録日 2017-12-20 公開日 2018-05-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc.Natl.Acad.Sci.USA, 115, 2018
6TLF	human 14-3-3 sigma isoform in complex with IMP 分子名称: 14-3-3 protein sigma, INOSINIC ACID, SULFATE ION 著者 Tassone, G, Pozzi, C, Mangani, S. 登録日 2019-12-02 公開日 2020-03-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction. Acs Chem.Biol., 15, 2020
4O46	14-3-3-gamma in complex with influenza NS1 C-terminal tail phosphorylated at S228 分子名称: 14-3-3 protein gamma, Nonstructural protein 1, UNKNOWN ATOM OR ION, ... 著者 Qin, S, Liu, Y, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2013-12-18 公開日 2014-04-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1. Nat Commun, 5, 2014
6QK8	Crystal structure of yeast 14-3-3 protein (Bmh1) from Saccharomyces cerevisiae with the Nha1p (yeast Na+/H+ antiporter) 14-3-3 binding motif Ser481 分子名称: Na(+)/H(+) antiporter, Protein BMH1 著者 Smidova, A, Obsil, T, Obsilova, V. 登録日 2019-01-28 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.917 Å) 主引用文献 The activity of Saccharomyces cerevisiae Na+, K+/H+antiporter Nha1 is negatively regulated by 14-3-3 protein binding at serine 481. Biochim Biophys Acta Mol Cell Res, 1866, 2019
5WXN	Structure of the LKB1 and 14-3-3 complex 分子名称: 14-3-3 protein zeta/delta, Serine/threonine-protein kinase STK11 著者 Ding, S, Shi, Z.B. 登録日 2017-01-08 公開日 2017-04-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.93 Å) 主引用文献 Structure of the complex of phosphorylated liver kinase B1 and 14-3-3 zeta Acta Crystallogr F Struct Biol Commun, 73, 2017
6T80	Human 14-3-3 sigma fused to the AANAT peptide including phosphoserine-205 分子名称: 14-3-3 protein sigma, AANAT peptide 著者 Sluchanko, N.N, Tugaeva, K.V, Titterington, J, Antson, A.A. 登録日 2019-10-23 公開日 2020-11-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 Human 14-3-3 sigma fused to the AANAT peptide including phosphoserine-205 To Be Published
6Y4K	Crystal structure of human 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser100 and Fusicoccin A 分子名称: 14-3-3 protein gamma, Calcium/calmodulin-dependent protein kinase kinase 2, FUSICOCCIN 著者 Lentini Santo, D, Obsilova, V, Obsil, T. 登録日 2020-02-21 公開日 2021-01-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins. Acs Chem.Biol., 15, 2020
6TM7	Human 14-3-3 sigma isoform in complex with PLP 分子名称: 14-3-3 protein sigma, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION 著者 Tassone, G, Pozzi, C, Mangani, S. 登録日 2019-12-03 公開日 2020-03-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction. Acs Chem.Biol., 15, 2020
6BYK	Structure of 14-3-3 beta/alpha bound to O-ClcNAc peptide 分子名称: 14-3-3 protein beta/alpha, 2-acetamido-2-deoxy-beta-D-glucopyranose, ATPPVSQASSTT O-GlcNac peptide 著者 Schumacher, M.A. 登録日 2017-12-20 公開日 2018-05-09 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. Proc.Natl.Acad.Sci.USA, 115, 2018
6Y6B	Crystal structure of human 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser100 and 16-OMe-Fusicoccin H 分子名称: (2~{R},3~{S},4~{S},5~{R},6~{S})-2-(hydroxymethyl)-6-[[(1~{S},3~{R},6~{S},7~{S},8~{R},9~{R},10~{R},11~{R},14~{S})-14-(me thoxymethyl)-3,10-dimethyl-9-oxidanyl-6-propan-2-yl-8-tricyclo[9.3.0.0^{3,7}]tetradecanyl]oxy]oxane-3,4,5-triol, 14-3-3 protein gamma, Calcium/calmodulin-dependent protein kinase kinase 2 著者 Lentini Santo, D, Obsilova, V, Obsil, T. 登録日 2020-02-26 公開日 2021-02-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 Stabilization of Protein-Protein Interactions between CaMKK2 and 14-3-3 by Fusicoccins. Acs Chem.Biol., 15, 2020
4J6S	14-3-3gamma complexed with the N-terminal sequence of tyrosine hydroxylase (residues 1-43) 分子名称: 14-3-3 protein gamma, N-terminal motif of tyrosine hydroxylase 著者 Mileni, M, Martinez, A, Stevens, R.C. 登録日 2013-02-11 公開日 2013-10-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes. J.Mol.Biol., 426, 2014
4ZQ0	crystal structure of Giardia 14-3-3 in complex with the phosphopeptide A8Ap 分子名称: 14-3-3 protein, A8Ap phosphopeptide, PHOSPHATE ION 著者 Fiorillo, A, Ilari, A. 登録日 2015-05-08 公開日 2016-03-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein-Protein Interactions. J.Chem.Inf.Model., 55, 2015
8DP5	Structure of the PEAK3/14-3-3 complex 分子名称: 14-3-3 protein beta/alpha, 14-3-3 protein epsilon, Protein PEAK3, ... 著者 Torosyan, H, Paul, M, Jura, N, Verba, K.A. 登録日 2022-07-14 公開日 2023-06-28 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3. Nat Commun, 14, 2023
5OEG	Molecular tweezers modulate 14-3-3 protein-protein interactions 分子名称: (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein sigma, CHLORIDE ION 著者 Bier, D, Ottmann, C. 登録日 2017-07-07 公開日 2017-07-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Molecular tweezers modulate 14-3-3 protein-protein interactions. Nat Chem, 5, 2013
7C8E	Crystal Structure of 14-3-3 epsilon with 9J10 peptide 分子名称: 14-3-3 protein epsilon, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 9J10 著者 Mathivanan, S, Sudhakar, S, Bairy, S, Kamariah, N, Venkitaraman, A. 登録日 2020-05-30 公開日 2021-06-02 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.16 Å) 主引用文献 Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library. Cell Chem Biol, 28, 2021

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