8T8C
| Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MFI-tripeptidyl-tRNA analog ACCA-IFMf at 2.60A resolution | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | 著者 | Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R. | 登録日 | 2023-06-22 | 公開日 | 2023-07-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics. Acs Chem.Biol., 18, 2023
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7RMF
| Substrate-bound Ura7 filament at low pH | 分子名称: | CTP synthase | 著者 | Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M. | 登録日 | 2021-07-27 | 公開日 | 2021-11-24 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (7.3 Å) | 主引用文献 | Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation. Elife, 10, 2021
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7RMV
| Yeast CTP Synthase (Ura7) H360R Filament bound to Substrates | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CTP synthase, URIDINE 5'-TRIPHOSPHATE | 著者 | Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M. | 登録日 | 2021-07-28 | 公開日 | 2021-11-24 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (6.7 Å) | 主引用文献 | Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation. Elife, 10, 2021
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7RMK
| Yeast CTP Synthase (Ura7) Bundle bound to substrates at low pH | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CTP synthase, URIDINE 5'-TRIPHOSPHATE | 著者 | Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M. | 登録日 | 2021-07-27 | 公開日 | 2021-11-24 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | 主引用文献 | Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation. Elife, 10, 2021
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5KYG
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7RNL
| Yeast CTP Synthase (Ura7) H360R Filament bound to Substrates | 分子名称: | CTP synthase, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION | 著者 | Hansen, J.M, Lynch, E.M, Farrell, D.P, DiMaio, F, Quispe, J, Kollman, J.M. | 登録日 | 2021-07-29 | 公開日 | 2021-11-24 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation. Elife, 10, 2021
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2XDG
| Crystal structure of the extracellular domain of human growth hormone releasing hormone receptor. | 分子名称: | 1,2-ETHANEDIOL, GROWTH HORMONE-RELEASING HORMONE RECEPTOR, MAGNESIUM ION | 著者 | Pike, A.C.W, Quigley, A, Barr, A.J, Burgess Brown, N, Shrestha, L, Yang, J, Chaikuad, A, Vollmar, M, Muniz, J.R.C, von Delft, F, Edwards, A, Arrowsmith, C.H, Weigelt, J, Bountra, C, Carpenter, E.P. | 登録日 | 2010-04-30 | 公開日 | 2010-06-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal Structure of the Extracellular Domain of Human Growth Hormone Releasing Hormone Receptor. To be Published
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3H65
| The Crystal Structure of C176A Mutated [Fe]-Hydrogenase (Hmd) Holoenzyme in Complex with Methylenetetrahydromethanopterin | 分子名称: | (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 5'-O-[(S)-hydroxy{[2-hydroxy-3,5-dimethyl-6-(2-oxoethyl)pyridin-4-yl]oxy}phosphoryl]guanosine, 5,10-DIMETHYLENE TETRAHYDROMETHANOPTERIN, ... | 著者 | Hiromoto, T, Warkentin, E, Shima, S, Ermler, U. | 登録日 | 2009-04-23 | 公開日 | 2009-09-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | The crystal structure of an [Fe]-hydrogenase-substrate complex reveals the framework for H2 activation. Angew.Chem.Int.Ed.Engl., 48, 2009
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3H6D
| Structure of the mycobacterium tuberculosis DUTPase D28N mutant | 分子名称: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ... | 著者 | Leveles, I, Harmat, V, Nagy, G, Takacs, E, Lopata, A, Toth, J, Vertessy, B.G. | 登録日 | 2009-04-23 | 公開日 | 2009-11-24 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases. Febs Lett., 584, 2010
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2XDH
| Non-cellulosomal cohesin from the hyperthermophilic archaeon Archaeoglobus fulgidus | 分子名称: | CHLORIDE ION, COHESIN, MAGNESIUM ION, ... | 著者 | Voronov-Goldman, M, Lamed, R, Noach, I, Borovok, I, Kwiat, M, Rosenheck, S, Shimon, L.J.W, Bayer, E.A, Frolow, F. | 登録日 | 2010-05-02 | 公開日 | 2010-05-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Non-Cellulosomal Cohesin from the Hyperthermophilic Archaeon Archaeoglobus Fulgidus Proteins, 79, 2011
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3H20
| Crystal structure of primase RepB' | 分子名称: | DIPHOSPHATE, Replication protein B, SULFATE ION | 著者 | Geibel, S, Banchenko, S, Engel, M, Lanka, E, Saenger, W. | 登録日 | 2009-04-14 | 公開日 | 2009-04-28 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structure and function of primase RepB' encoded by broad-host-range plasmid RSF1010 that replicates exclusively in leading-strand mode Proc.Natl.Acad.Sci.USA, 106, 2009
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3HAM
| Structure of the gentamicin-APH(2")-IIa complex | 分子名称: | (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, Aminoglycoside phosphotransferase, GLYCEROL | 著者 | Young, P.G, Baker, E.N, Vakulenko, S.B, Smith, C.A. | 登録日 | 2009-05-02 | 公開日 | 2009-07-28 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'')-IIa] provide insights into substrate selectivity in the APH(2'') subfamily. J.Bacteriol., 191, 2009
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3HB0
| Structure of edeya2 complexed with bef3 | 分子名称: | BERYLLIUM TRIFLUORIDE ION, Eyes absent homolog 2 (Drosophila), MAGNESIUM ION | 著者 | Jung, S.K, Jeong, D.G, Ryu, S.E, Kim, S.J. | 登録日 | 2009-05-03 | 公開日 | 2009-12-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor Faseb J., 24, 2010
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5KDH
| CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A DIHYDROPYRIDOPYRIMIDINE SCAFFOLD INHIBITOR | 分子名称: | (5~{S})-1-ethyl-5-(4-methylphenyl)-8,9-dihydro-5~{H}-furo[3,4]pyrido[3,5-~{b}]pyrimidine-2,4,6-trione, 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ... | 著者 | Zhu, J.-Y, Schonbrunn, E. | 登録日 | 2016-06-08 | 公開日 | 2017-08-02 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen. J. Med. Chem., 60, 2017
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5KDU
| ZmpB metallopeptidase in complex with a2,6-Sialyl T-antigen | 分子名称: | 1,2-ETHANEDIOL, F5/8 type C domain protein, SERINE, ... | 著者 | Noach, I, Ficko-Blean, E, Stuart, C, Boraston, A.B. | 登録日 | 2016-06-08 | 公開日 | 2017-01-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Recognition of protein-linked glycans as a determinant of peptidase activity. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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3H40
| Binary complex of human DNA polymerase iota with template U/T | 分子名称: | 5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3', 5'-D(*TP*(BRU)P*GP*GP*GP*TP*CP*CP*T)-3', DNA polymerase iota, ... | 著者 | Jain, R, Nair, D.T, Johnson, R.E, Prakash, L, Prakash, S, Aggarwal, A.K. | 登録日 | 2009-04-17 | 公開日 | 2009-07-21 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Replication across template T/U by human DNA polymerase-iota. Structure, 17, 2009
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2XG6
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3GLB
| Crystal structure of the effector binding domain of a CATM variant (R156H) | 分子名称: | (2Z,4Z)-HEXA-2,4-DIENEDIOIC ACID, GLYCEROL, HTH-type transcriptional regulator catM, ... | 著者 | Ezezika, O.C, Craven, S.H, Neidle, E.L, Momany, C. | 登録日 | 2009-03-11 | 公開日 | 2009-05-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Inducer responses of BenM, a LysR-type transcriptional regulator from Acinetobacter baylyi ADP1. Mol.Microbiol., 72, 2009
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3H64
| Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Mn2+ atoms complexed with endothall | 分子名称: | (1R,2S,3R,4S)-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, MANGANESE (II) ION, Serine/threonine-protein phosphatase 5 | 著者 | Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E. | 登録日 | 2009-04-23 | 公開日 | 2009-09-29 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin J.Med.Chem., 52, 2009
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2FNF
| C1 domain of Nore1 | 分子名称: | ZINC ION, putative Ras Effector Nore1 | 著者 | Harjes, E, Harjes, S, Wohlgemuth, S, Krieger, E, Herrmann, C, Muller, K.H, Bayer, P. | 登録日 | 2006-01-11 | 公開日 | 2006-02-07 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | GTP-Ras disrupts the intramolecular complex of C1 and RA domains of Nore1. Structure, 14, 2006
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3GNI
| Structure of STRAD and MO25 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CITRIC ACID, Protein Mo25, ... | 著者 | Zeqiraj, E, Goldie, S, Alessi, D.R, van Aalten, D.M.F. | 登録日 | 2009-03-17 | 公開日 | 2009-06-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor Plos Biol., 7, 2009
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3H9B
| Structure of a mutant methionyl-tRNA synthetase with modified specificity complexed with azidonorleucine | 分子名称: | 6-azido-L-norleucine, CITRIC ACID, Methionyl-tRNA synthetase, ... | 著者 | Schmitt, E, Tanrikulu, I.C, Yoo, T.H, Panvert, M, Tirrell, D.A, Mechulam, Y. | 登録日 | 2009-04-30 | 公開日 | 2009-12-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Switching from an induced-fit to a lock-and-key mechanism in an aminoacyl-tRNA synthetase with modified specificity. J.Mol.Biol., 394, 2009
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2G3J
| Structure of S.olivaceoviridis xylanase Q88A/R275A mutant | 分子名称: | PHOSPHATE ION, Xylanase, alpha-D-xylopyranose-(1-4)-alpha-D-xylopyranose | 著者 | Diertavitian, S, Kaneko, S, Fujimoto, Z, Kuno, A, Johansson, E, Lo Leggio, L. | 登録日 | 2006-02-20 | 公開日 | 2007-03-06 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure-based engineering of glucose specificity in a family 10 xylanase from Streptomyces olivaceoviridis E-86 PROCESS BIOCHEM, 47, 2012
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3GO0
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2XXM
| Crystal structure of the HIV-1 capsid protein C-terminal domain in complex with a camelid VHH and the CAI peptide. | 分子名称: | ACETATE ION, CAMELID VHH 9, CAPSID PROTEIN P24, ... | 著者 | Igonet, S, Vaney, M.C, Bartonova, V, Helma, J, Rothbauer, U, Leonhardt, H, Stura, E, Krausslich, H.-G, Rey, F.A. | 登録日 | 2010-11-10 | 公開日 | 2011-10-12 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Targeting HIV-1 Virion Formation with Nanobodies -Implications for the Design of Assembly Inhibitors To be Published
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