3HAM

Structure of the gentamicin-APH(2")-IIa complex

Summary for 3HAM

Entry DOI	10.2210/pdb3ham/pdb
Related	3HAV
Descriptor	Aminoglycoside phosphotransferase, (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, GLYCEROL, ... (4 entities in total)
Functional Keywords	aminoglycoside, gentamicin, antibiotic resistance, transferase
Biological source	Enterococcus faecium (Streptococcus faecium)
Total number of polymer chains	2
Total formula weight	72063.94
Authors	Young, P.G.,Baker, E.N.,Vakulenko, S.B.,Smith, C.A. (deposition date: 2009-05-02, release date: 2009-07-28, Last modification date: 2024-02-21)
Primary citation	Young, P.G.,Walanj, R.,Lakshmi, V.,Byrnes, L.J.,Metcalf, P.,Baker, E.N.,Vakulenko, S.B.,Smith, C.A. The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'')-IIa] provide insights into substrate selectivity in the APH(2'') subfamily. J.Bacteriol., 191:4133-4143, 2009 Cited by PubMed: 19429619 DOI: 10.1128/JB.00149-09 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation