3HAV

Structure of the streptomycin-ATP-APH(2")-IIa ternary complex

Summary for 3HAV

• Entry DOI: 10.2210/pdb3hav/pdb
• Related: 3ham
• Descriptor: Aminoglycoside phosphotransferase, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: aminoglycoside, streptomycin, antibiotic resistance, transferase
• Biological source: Enterococcus faecium (Streptococcus faecium)
• Total number of polymer chains: 3
• Total formula weight: 109533.89

Authors

Young, P.G.,Baker, E.N.,Vakulenko, S.B.,Smith, C.A. (deposition date: 2009-05-02, release date: 2009-11-17, Last modification date: 2023-09-06)

• Primary citation: Young, P.G.,Walanj, R.,Lakshmi, V.,Byrnes, L.J.,Metcalf, P.,Baker, E.N.,Vakulenko, S.B.,Smith, C.A.; The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'')-IIa] provide insights into substrate selectivity in the APH(2'') subfamily.; J.Bacteriol., 191:4133-4143, 2009; PubMed: 19429619; DOI: 10.1128/JB.00149-09

Experimental method

X-RAY DIFFRACTION (2.45 Å)