8VEO
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![BU of 8veo by Molmil](/molmil-images/mine/8veo) | Crystal structure of PRMT5:MEP50 in complex with MTA | 分子名称: | 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, DI(HYDROXYETHYL)ETHER, ... | 著者 | Whittington, D.A. | 登録日 | 2023-12-20 | 公開日 | 2024-04-24 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP -Deleted Cancers. J.Med.Chem., 67, 2024
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8VEX
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![BU of 8vex by Molmil](/molmil-images/mine/8vex) | |
8VET
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![BU of 8vet by Molmil](/molmil-images/mine/8vet) | |
8VEY
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![BU of 8vey by Molmil](/molmil-images/mine/8vey) | |
8YY8
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![BU of 8yy8 by Molmil](/molmil-images/mine/8yy8) | Fzd7 -Gs complex | 分子名称: | Frizzled-7, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Chen, B, Xu, L, Han, G.W, Xu, F. | 登録日 | 2024-04-03 | 公開日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G s . Cell Res., 31, 2021
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7JHJ
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![BU of 7jhj by Molmil](/molmil-images/mine/7jhj) | Structure of the Epstein-Barr virus GPCR BILF1 in complex with human Gi | 分子名称: | Antibody fragment scFv16, BILF1, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Tsutsumi, N, Qu, Q.H, Skiniotis, G, Garcia, K.C. | 登録日 | 2020-07-20 | 公開日 | 2021-07-07 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis for the constitutive activity and immunomodulatory properties of the Epstein-Barr virus-encoded G protein-coupled receptor BILF1. Immunity, 54, 2021
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7KSO
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![BU of 7kso by Molmil](/molmil-images/mine/7kso) | Cryo-EM structure of PRC2:EZH1-AEBP2-JARID2 | 分子名称: | Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, ... | 著者 | Grau, D.J, Armache, K.J. | 登録日 | 2020-11-23 | 公開日 | 2021-02-03 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction. Nat Commun, 12, 2021
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7KQQ
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![BU of 7kqq by Molmil](/molmil-images/mine/7kqq) | Crystal structure of human WDR55 | 分子名称: | UNKNOWN ATOM OR ION, WD repeat-containing protein 55 | 著者 | Zeng, H, Hutchinson, A, Li, Y, Seitova, A, Edwards, A.M, Arrowsmith, C.H, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2020-11-17 | 公開日 | 2020-12-30 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of human WDR55 To Be Published
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7KSR
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![BU of 7ksr by Molmil](/molmil-images/mine/7ksr) | PRC2:EZH1_A from a dimeric PRC2 bound to a nucleosome | 分子名称: | Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, ... | 著者 | Grau, D.J, Armache, K.J. | 登録日 | 2020-11-24 | 公開日 | 2021-02-03 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction. Nat Commun, 12, 2021
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7KYX
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![BU of 7kyx by Molmil](/molmil-images/mine/7kyx) | Crystal structure of human CORO6 | 分子名称: | Coronin-6, UNKNOWN ATOM OR ION | 著者 | Zeng, H, Dong, A, Loppnau, P, Hutchinson, A, Seitova, A, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | 登録日 | 2020-12-09 | 公開日 | 2021-01-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Crystal structure of human CORO6 To Be Published
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7KZN
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![BU of 7kzn by Molmil](/molmil-images/mine/7kzn) | Outer dynein arm core subcomplex from C. reinhardtii | 分子名称: | DC1, DC2, Dynein 11 kDa light chain, ... | 著者 | Walton, T, Wu, H, Brown, A.B. | 登録日 | 2020-12-10 | 公開日 | 2021-01-20 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structure of a microtubule-bound axonemal dynein. Nat Commun, 12, 2021
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7KTP
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![BU of 7ktp by Molmil](/molmil-images/mine/7ktp) | PRC2:EZH1_B from a dimeric PRC2 bound to a nucleosome | 分子名称: | Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH1, Polycomb protein EED, ... | 著者 | Grau, D.J, Armache, K.J. | 登録日 | 2020-11-24 | 公開日 | 2021-02-03 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction. Nat Commun, 12, 2021
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7L1G
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![BU of 7l1g by Molmil](/molmil-images/mine/7l1g) | PRMT5-MEP50 Complexed with SAM | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Methylosome protein 50, ... | 著者 | Palte, R.L. | 登録日 | 2020-12-14 | 公開日 | 2021-04-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Development of a Flexible and Robust Synthesis of Tetrahydrofuro[3,4- b ]furan Nucleoside Analogues. J.Org.Chem., 86, 2021
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7KID
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![BU of 7kid by Molmil](/molmil-images/mine/7kid) | PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 72 | 分子名称: | (1S,2R,3aR,4S,6aR)-4-[(2-amino-3,5-difluoroquinolin-7-yl)methyl]-2-(4-amino-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydropentalene-1,6a(1H)-diol, 1,2-ETHANEDIOL, Methylosome protein 50, ... | 著者 | Palte, R.L. | 登録日 | 2020-10-23 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer. J.Med.Chem., 64, 2021
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7KIC
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![BU of 7kic by Molmil](/molmil-images/mine/7kic) | PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 34 | 分子名称: | (2R,3R,3aS,6S,6aR)-6-[(2-amino-3-bromoquinolin-7-yl)oxy]-2-(4-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydro-3aH-cyclopenta[b]furan-3,3a-diol, 1,2-ETHANEDIOL, Methylosome protein 50, ... | 著者 | Palte, R.L. | 登録日 | 2020-10-23 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer. J.Med.Chem., 64, 2021
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7KIB
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![BU of 7kib by Molmil](/molmil-images/mine/7kib) | PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 4 | 分子名称: | (2R,3R,3aS,6S,6aR)-6-[(2-amino-3-bromoquinolin-7-yl)oxy]-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydro-3aH-cyclopenta[b]furan-3,3a-diol, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Palte, R.L, Hayes, R.P. | 登録日 | 2020-10-23 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer. J.Med.Chem., 64, 2021
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7KTR
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![BU of 7ktr by Molmil](/molmil-images/mine/7ktr) | Cryo-EM structure of the human SAGA coactivator complex (TRRAP, core) | 分子名称: | Ataxin-7, INOSITOL HEXAKISPHOSPHATE, Isoform 3 of Transcription factor SPT20 homolog, ... | 著者 | Herbst, D.A, Esbin, M.N, Nogales, E. | 登録日 | 2020-11-24 | 公開日 | 2021-11-10 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | Structure of the human SAGA coactivator complex. Nat.Struct.Mol.Biol., 28, 2021
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7KTS
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![BU of 7kts by Molmil](/molmil-images/mine/7kts) | Negative stain EM structure of the human SAGA coactivator complex (TRRAP, core, splicing module) | 分子名称: | Ataxin-7, Isoform 3 of Transcription factor SPT20 homolog, STAGA complex 65 subunit gamma, ... | 著者 | Herbst, D.A, Esbin, M.N, Nogales, E. | 登録日 | 2020-11-24 | 公開日 | 2021-11-10 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (19.09 Å) | 主引用文献 | Structure of the human SAGA coactivator complex. Nat.Struct.Mol.Biol., 28, 2021
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6M94
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![BU of 6m94 by Molmil](/molmil-images/mine/6m94) | Monophosphorylated pSer33 b-Catenin peptide bound to b-TrCP/Skp1 Complex | 分子名称: | Catenin beta-1, DIMETHYL SULFOXIDE, F-box/WD repeat-containing protein 1A, ... | 著者 | Simonetta, K.R, Clifton, M.C, Walter, R.L, Ranieri, G.M, Carter, J.J. | 登録日 | 2018-08-22 | 公開日 | 2019-04-03 | 最終更新日 | 2019-04-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun, 10, 2019
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6M91
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![BU of 6m91 by Molmil](/molmil-images/mine/6m91) | Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-103094 ternary complex | 分子名称: | 3-({4-[(2,6-dichlorophenyl)sulfanyl]-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl}amino)benzoic acid, CHLORIDE ION, Catenin beta-1, ... | 著者 | Simonetta, K.R, Clifton, M.C, Walter, R.L, Ranieri, G.M, Carter, J.J. | 登録日 | 2018-08-22 | 公開日 | 2019-04-03 | 最終更新日 | 2019-04-10 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun, 10, 2019
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5TEE
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![BU of 5tee by Molmil](/molmil-images/mine/5tee) | Crystal structure of Gemin5 WD40 repeats in apo form | 分子名称: | GLYCEROL, Gem-associated protein 5, SODIUM ION, ... | 著者 | Chao, X, Tempel, W, Bian, C, Cerovina, T, He, H, Walker, J.R, Seitova, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2016-09-21 | 公開日 | 2016-10-19 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly. Genes Dev., 30, 2016
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6LT0
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![BU of 6lt0 by Molmil](/molmil-images/mine/6lt0) | cryo-EM structure of C9ORF72-SMCR8-WDR41 | 分子名称: | Guanine nucleotide exchange C9orf72, Guanine nucleotide exchange protein SMCR8, WD repeat-containing protein 41 | 著者 | Tang, D, Sheng, J, Xu, L, Zhan, X, Yan, C, Qi, S. | 登録日 | 2020-01-21 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a. Proc.Natl.Acad.Sci.USA, 117, 2020
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6M93
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![BU of 6m93 by Molmil](/molmil-images/mine/6m93) | Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-1933 ternary complex | 分子名称: | 2-oxo-N-[3-(1H-tetrazol-5-yl)phenyl]-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide, Catenin beta-1, F-box/WD repeat-containing protein 1A, ... | 著者 | Simonetta, K.R, Clifton, M.C, Walter, R.L, Ranieri, G.M, Lee, S.J. | 登録日 | 2018-08-22 | 公開日 | 2019-04-03 | 最終更新日 | 2019-04-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun, 10, 2019
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5TQR
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![BU of 5tqr by Molmil](/molmil-images/mine/5tqr) | |
6M92
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![BU of 6m92 by Molmil](/molmil-images/mine/6m92) | Monophosphorylated pSer33 b-Catenin peptide, b-TrCP/Skp1, NRX-2663 ternary complex | 分子名称: | 3-{[2-oxo-4-phenoxy-6-(trifluoromethyl)-1,2-dihydropyridine-3-carbonyl]amino}benzoic acid, Catenin beta-1, F-box/WD repeat-containing protein 1A, ... | 著者 | Simonetta, K.R, Clifton, M.C, Walter, R.L, Ranieri, G.M, Carter, J.J, Lee, S.J. | 登録日 | 2018-08-22 | 公開日 | 2019-04-03 | 最終更新日 | 2020-01-15 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun, 10, 2019
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