8QMK
 
 | | Enzymatically-produced complex-B bound TmHydE structure | | 分子名称: | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, CARBON MONOXIDE, CHLORIDE ION, ... | | 著者 | Omeiri, J, Martin, L, Usclat, A, Cherrier, M.V, Nicolet, Y. | | 登録日 | 2023-09-22 | | 公開日 | 2023-11-22 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Maturation of the [FeFe]-Hydrogenase: Direct Transfer of the ( kappa 3 -cysteinate)Fe II (CN)(CO) 2 Complex B from HydG to HydE.
Angew.Chem.Int.Ed.Engl., 62, 2023
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8QML
 | | (2R,4R)-MeTDA bound HydE structure (control experiment) | | 分子名称: | (2R,4R)-2-methyl-1,3-thiazolidine-2,4-dicarboxylic acid, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, CHLORIDE ION, ... | | 著者 | Omeiri, J, Martin, L, Usclat, A, Cherrier, M.V, Nicolet, Y. | | 登録日 | 2023-09-22 | | 公開日 | 2023-11-22 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Maturation of the [FeFe]-Hydrogenase: Direct Transfer of the ( kappa 3 -cysteinate)Fe II (CN)(CO) 2 Complex B from HydG to HydE.
Angew.Chem.Int.Ed.Engl., 62, 2023
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8P3N
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7NDZ
 | | ThyX reconstituted with N5-carbinolamine flavin | | 分子名称: | DI(HYDROXYETHYL)ETHER, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent thymidylate synthase, ... | | 著者 | Bou-Nader, C, Pecqueur, L, Hamdane, D. | | 登録日 | 2021-02-02 | | 公開日 | 2021-07-21 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | An enzymatic activation of formaldehyde for nucleotide methylation.
Nat Commun, 12, 2021
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7NDW
 | | ThyX-FADH2 soaked with 20 mM Formaldehyde | | 分子名称: | DI(HYDROXYETHYL)ETHER, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent thymidylate synthase, ... | | 著者 | Bou-Nader, C, Pecqueur, L, Hamdane, D. | | 登録日 | 2021-02-02 | | 公開日 | 2021-07-21 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | An enzymatic activation of formaldehyde for nucleotide methylation.
Nat Commun, 12, 2021
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2H4J
 | | Sir2-deacetylated peptide (from enzymatic turnover in crystal) | | 分子名称: | 2'-O-ACETYL ADENOSINE-5-DIPHOSPHORIBOSE, Cellular tumor antigen p53, NAD-dependent deacetylase, ... | | 著者 | Hoff, K.G, Avalos, J.L, Sens, K, Wolberger, C. | | 登録日 | 2006-05-24 | | 公開日 | 2006-09-05 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD(+) and Acetylated Peptide.
Structure, 14, 2006
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2H59
 | | Sir2 H116A-deacetylated p53 peptide-3'-o-acetyl ADP ribose | | 分子名称: | (2S,3S,4R,5S)-2-({[(S)-{[(S)-{[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-4,5-DIHYDROXYTETRAHYDROFURAN-3-YL ACETATE, ADENOSINE-5-DIPHOSPHORIBOSE, Cellular tumor antigen p53, ... | | 著者 | Hoff, K.G, Avalos, J.L, Sens, K, Wolberger, C. | | 登録日 | 2006-05-25 | | 公開日 | 2006-09-05 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Insights into the Sirtuin Mechanism from Ternary Complexes Containing NAD(+) and Acetylated Peptide.
Structure, 14, 2006
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8ZYG
 | | Crystal structure of a cupin protein (tm1459, I49C-4py/H52A/C106D mutant) in copper (Cu) substituted form | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, COPPER (II) ION, Cupin type-2 domain-containing protein, ... | | 著者 | Morita, Y, Kubo, H, Matsumoto, R, Fujieda, N. | | 登録日 | 2024-06-17 | | 公開日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | | 主引用文献 | Copper center in artificial non-heme metalloenzyme
To Be Published
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9FO3
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8ZYH
 | | Crystal structure of a cupin protein (tm1459, I49C-4py/H52A/H54A/C106D mutant) in copper (Cu) substituted form | | 分子名称: | COPPER (II) ION, Cupin type-2 domain-containing protein, HEXAETHYLENE GLYCOL | | 著者 | Morita, Y, Kubo, H, Matsumoto, R, Fujieda, N. | | 登録日 | 2024-06-17 | | 公開日 | 2024-09-04 | | 実験手法 | X-RAY DIFFRACTION (1.07 Å) | | 主引用文献 | Copper center in artificial non-heme metalloenzyme
To Be Published
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6X1Z
 | | Mre11 dimer in complex with small molecule modulator PFMJ | | 分子名称: | (5Z)-5-[(3,4-dimethoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, ... | | 著者 | Arvai, A.S, Moiani, D, Tainer, J.A. | | 登録日 | 2020-05-19 | | 公開日 | 2020-06-10 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response.
Prog.Biophys.Mol.Biol., 163, 2021
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6X1Y
 | | Mre11 dimer in complex with small molecule modulator PFMI | | 分子名称: | (5Z)-5-[(3-methoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Nuclease SbcCD subunit D | | 著者 | Arvai, A.S, Moiani, D, Tainer, J.A. | | 登録日 | 2020-05-19 | | 公開日 | 2020-06-10 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response.
Prog.Biophys.Mol.Biol., 163, 2021
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5IOS
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5IOT
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8SZZ
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5IOQ
 | | Flavin-dependent thymidylate synthase in complex with FAD and deoxyuridine | | 分子名称: | 2'-DEOXYURIDINE, FLAVIN-ADENINE DINUCLEOTIDE, TRIETHYLENE GLYCOL, ... | | 著者 | Bernard, S.M, Stull, F.W, Smith, J.L. | | 登録日 | 2016-03-08 | | 公開日 | 2016-06-08 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Deprotonations in the Reaction of Flavin-Dependent Thymidylate Synthase.
Biochemistry, 55, 2016
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5JFE
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1XR2
 | | Crystal Structure of oxidized T. maritima Cobalamin-Independent Methionine Synthase complexed with Methyltetrahydrofolate | | 分子名称: | 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, MESO-ERYTHRITOL, ... | | 著者 | Pejchal, R, Ludwig, M.L. | | 登録日 | 2004-10-13 | | 公開日 | 2005-03-01 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication
Plos Biol., 3, 2005
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1XPG
 | | Crystal Structure of T. maritima Cobalamin-Independent Methionine Synthase complexed with Zn2+ and Methyltetrahydrofolate | | 分子名称: | 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase, MESO-ERYTHRITOL, ... | | 著者 | Pejchal, R, Ludwig, M.L. | | 登録日 | 2004-10-08 | | 公開日 | 2005-03-01 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication
Plos Biol., 3, 2005
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1JG8
 | | Crystal Structure of Threonine Aldolase (Low-specificity) | | 分子名称: | CALCIUM ION, L-allo-threonine aldolase, SODIUM ION | | 著者 | Kielkopf, C.L, Bonanno, J, Ray, S, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2001-06-23 | | 公開日 | 2001-07-04 | | 最終更新日 | 2021-02-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal Structure of Low-specificity Threonine Aldolase, a Key Enzyme in Glycine Biosynthesis
To be published
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3C1Y
 | | Structure of bacterial DNA damage sensor protein with co-purified and co-crystallized ligand | | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, DNA integrity scanning protein disA | | 著者 | Witte, G, Hartung, S, Buttner, K, Hopfner, K.P. | | 登録日 | 2008-01-24 | | 公開日 | 2008-05-06 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates
Mol.Cell, 30, 2008
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8VHH
 | | Engineered holo tryptophan synthase (Tm9D8*) derived from T. maritima TrpB | | 分子名称: | PHOSPHATE ION, POTASSIUM ION, PYRIDOXAL-5'-PHOSPHATE, ... | | 著者 | Porter, N.J, Johnston, K.E, Almhjell, P.J, Arnold, F.H. | | 登録日 | 2024-01-02 | | 公開日 | 2024-08-14 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | A combinatorially complete epistatic fitness landscape in an enzyme active site.
Proc.Natl.Acad.Sci.USA, 121, 2024
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3C21
 | | Structure of a bacterial DNA damage sensor protein with reaction product | | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, DNA integrity scanning protein disA | | 著者 | Witte, G, Hartung, S, Buttner, K, Hopfner, K.P. | | 登録日 | 2008-01-24 | | 公開日 | 2008-05-06 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates
Mol.Cell, 30, 2008
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1XDJ
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3C23
 | | Structure of a bacterial DNA damage sensor protein with non-reactive Ligand | | 分子名称: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, DNA integrity scanning protein disA | | 著者 | Witte, G, Hartung, S, Buttner, K, Hopfner, K.P. | | 登録日 | 2008-01-24 | | 公開日 | 2008-05-06 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates
Mol.Cell, 30, 2008
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