7NDZ

ThyX reconstituted with N5-carbinolamine flavin

Summary for 7NDZ

• Entry DOI: 10.2210/pdb7ndz/pdb
• Related: 7NDW
• Descriptor: Flavin-dependent thymidylate synthase, TRIETHYLENE GLYCOL, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-[5-methanoyl-7,8-dimethyl-2,4-bis(oxidanylidene)-1H-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate, ... (6 entities in total)
• Functional Keywords: flavin-dependent thymidylate synthase, methylenetetrahydrofolate, transferase
• Biological source: Thermotoga maritima
• Total number of polymer chains: 4
• Total formula weight: 113611.43

Authors

Bou-Nader, C.,Pecqueur, L.,Hamdane, D. (deposition date: 2021-02-02, release date: 2021-07-21, Last modification date: 2024-01-31)

• Primary citation: Bou-Nader, C.,Stull, F.W.,Pecqueur, L.,Simon, P.,Guerineau, V.,Royant, A.,Fontecave, M.,Lombard, M.,Palfey, B.A.,Hamdane, D.; An enzymatic activation of formaldehyde for nucleotide methylation.; Nat Commun, 12:4542-4542, 2021; PubMed: 34315871; DOI: 10.1038/s41467-021-24756-8

Experimental method

X-RAY DIFFRACTION (2.7 Å)