PDB: 615 件ウェブページステータス検索Chemie searchBIRD

---

5LU1	Human 14-3-3 sigma CLU3 mutant complexed with short HSPB6 phosphopeptide 分子名称: 14-3-3 protein sigma, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Heat shock protein beta-6 著者 Sluchanko, N.N, Beelen, S, Kulikova, A.A, Weeks, S.D, Antson, A.A, Gusev, N.B, Strelkov, S.V. 登録日 2016-09-07 公開日 2017-02-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator. Structure, 25, 2017
1YWT	Crystal structure of the human sigma isoform of 14-3-3 in complex with a mode-1 phosphopeptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, synthetic optimal phosphopeptide (mode-1) 著者 Wilker, E.W, Grant, R.A, Artim, S.C, Yaffe, M.B. 登録日 2005-02-18 公開日 2005-03-01 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A structural basis for 14-3-3sigma functional specificity. J.Biol.Chem., 280, 2005
3NKX	Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome 分子名称: 14-3-3 protein zeta/delta, PROPANOIC ACID, Peptide of RAF proto-oncogene serine/threonine-protein kinase 著者 Schumacher, B, Weyand, M, Ottmann, C. 登録日 2010-06-21 公開日 2010-09-15 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling Mol.Cell.Biol., 30, 2010
3AXY	Structure of Florigen Activation Complex Consisting of Rice Florigen Hd3a, 14-3-3 Protein GF14 and Rice FD Homolog OsFD1 分子名称: 14-3-3-like protein GF14-C, Protein HEADING DATE 3A, Rice FD homolog OsFD1 著者 Ohki, I, Furuita, K, Hayashi, K, Taoka, K, Tsuji, H, Nakagawa, A, Shimamoto, K, Kojima, C. 登録日 2011-04-19 公開日 2011-08-03 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 14-3-3 proteins act as intracellular receptors for rice Hd3a florigen Nature, 476, 2011
3CU8	Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome 分子名称: 14-3-3 protein zeta/delta, MAGNESIUM ION, PROPANOIC ACID, ... 著者 Schumacher, B, Weyand, M, Kuhlmann, J, Ottmann, C. 登録日 2008-04-16 公開日 2009-05-05 最終更新日 2017-10-25 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol. Cell. Biol., 30, 2010
4WRQ	Crystal Structure of 14-3-3 zeta with Chibby peptide 分子名称: 14-3-3 protein zeta/delta, Chibby 著者 Killoran, R.C, Shilton, B.H, Choy, W.Y. 登録日 2014-10-24 公開日 2015-05-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.409 Å) 主引用文献 Structural Analysis of the 14-3-3 zeta /Chibby Interaction Involved in Wnt/ beta-Catenin Signaling. Plos One, 10, 2015
4GNT	Complex of ChREBP and 14-3-3beta 分子名称: 14-3-3 protein beta/alpha, Carbohydrate-responsive element-binding protein, SULFATE ION 著者 Zhang, H, Huang, N. 登録日 2012-08-17 公開日 2012-10-24 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Crystal Structure of Carbohydrate Response Element Binding Protein (ChREBP) in complex with 14-3-3b To be Published
7D8H	CRTC1 pSer64 peptide in complex with 14-3-3 zeta 分子名称: 14-3-3 protein zeta/delta, CRTC1 pSer64 peptide 著者 Chen, H, Zhang, H, Xiang, S. 登録日 2020-10-08 公開日 2021-02-24 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Structural Insights into the Interaction Between CRTCs and 14-3-3. J.Mol.Biol., 433, 2021
6EF5	14-3-3 with peptide 分子名称: 14-3-3 protein zeta/delta, ARG-SER-LEU-SEP-ALA-PRO-GLY, LYS-LEU-SEP-LEU-GLN 著者 Dhagat, U, Langendorf, C.G, Parker, M.W.P, Oakhill, J.S, Scott, J.W. 登録日 2018-08-16 公開日 2019-10-30 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.44 Å) 主引用文献 14-3-3 with peptide To Be Published
7XBQ	Crystal structure of potato 14-3-3 protein St14f 分子名称: Putative 14-3-3 protein 著者 Harada, K, Kojima, C, Yamashita, E, Nakagawa, A. 登録日 2022-03-21 公開日 2022-07-20 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Crystal structure of potato 14-3-3 protein St14f revealed the importance of helix I in StFDL1 recognition. Sci Rep, 12, 2022
5M36	The molecular tweezer CLR01 stabilizes a disordered protein-protein interface 分子名称: (1R,5S,9S,16R,20R,24S,28S,35R)-3,22-Bis(dihydroxyphosphoryloxy)tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2(23),3,6,8(17),10,12,14,18,21,25,27(36),29,31,33,37-pentadecaene, 14-3-3 protein zeta/delta, BENZOIC ACID, ... 著者 Bier, D, Ottmann, C. 登録日 2016-10-14 公開日 2017-11-15 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface. J. Am. Chem. Soc., 139, 2017
6TL3	Crystal structure of an Estrogen Receptor alpha 8-mer phosphopeptide in complex with 14-3-3sigma stabilized by a Pyrrolidone1 derivative 分子名称: 14-3-3 protein sigma, 5-[(2~{S},3~{R})-3-[(~{R})-azanyl(phenyl)methyl]-2-(4-nitrophenyl)-4,5-bis(oxidanylidene)pyrrolidin-1-yl]-2-oxidanyl-benzoic acid, Estrogen receptor 著者 Andrei, S.A, Bosica, F, Ottmann, C, O'Mahony, G. 登録日 2019-11-30 公開日 2020-04-29 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.455 Å) 主引用文献 Design of Drug-Like Protein-Protein Interaction Stabilizers Guided By Chelation-Controlled Bioactive Conformation Stabilization. Chemistry, 26, 2020
3E6Y	Structure of 14-3-3 in complex with the differentiation-inducing agent Cotylenin A 分子名称: 14-3-3-like protein C, CHLORIDE ION, Cotylenin A, ... 著者 Ottmann, C, Weyand, M, Wittinghofer, A, Oecking, C. 登録日 2008-08-17 公開日 2009-03-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A J.Mol.Biol., 386, 2009
6ZVD	14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 96h incubation 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide 著者 Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. 登録日 2020-07-24 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes To Be Published
7A6Y	Structure of 14-3-3 gamma in complex with DAPK2 peptide stabilized by FC-A 分子名称: 14-3-3 protein gamma, DAPK2 C-terminal peptide, FUSICOCCIN 著者 Horvath, M, Obsilova, V, Obsil, T. 登録日 2020-08-27 公開日 2021-08-25 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites. Commun Biol, 4, 2021
7PWZ	Crystal structure of 14-3-3 sigma in complex with a C-terminal Estrogen Receptoralpha phosphopeptide, stabilised by Pyrrolidone1 derivative 228 分子名称: 14-3-3 protein sigma, 2-oxidanyl-5-[(2~{R})-4-oxidanyl-5-oxidanylidene-2-(1-oxidanylidene-3~{H}-2-benzofuran-5-yl)-3-(phenylcarbonyl)-2~{H}-pyrrol-1-yl]benzoic acid, C-terminus of Estrogen receptor alpha, ... 著者 Andrei, S.A, Bosica, F, O'Mahony, G, Ottmann, C. 登録日 2021-10-07 公開日 2022-12-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction. J.Med.Chem., 65, 2022
6Y7T	Engineered conjugation of lysine-specific molecular tweezers with ExoS derived peptidic inhibitor enhance affinity towards target protein 14-3-3 through ditopic binding 分子名称: 14-3-3 protein sigma, ExoSTWZ molecular tweezer, Exoenzyme S, ... 著者 Guillory, X, Ottmann, C. 登録日 2020-03-02 公開日 2021-03-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Supramolecular Enhancement of a Natural 14-3-3 Protein Ligand. J.Am.Chem.Soc., 143, 2021
2BQ0	14-3-3 Protein Beta (Human) 分子名称: 14-3-3 BETA/ALPHA 著者 Yang, X, Elkins, J.M, Fedorov, O, Longman, E.J, Sobott, L, Ball, L.J, Sundstrom, M, Arrowsmith, C, Edwards, A, Doyle, D.A. 登録日 2005-04-26 公開日 2005-05-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc.Natl.Acad.Sci.USA, 103, 2006
5LU2	Human 14-3-3 sigma complexed with long HSPB6 phosphopeptide 分子名称: 14-3-3 protein sigma, Heat shock protein beta-6 著者 Sluchanko, N.N, Beelen, S, Kulikova, A.A, Weeks, S.D, Antson, A.A, Gusev, N.B, Strelkov, S.V. 登録日 2016-09-07 公開日 2017-02-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator. Structure, 25, 2017
6U2H	BRAF dimer bound to 14-3-3 分子名称: 14-3-3 protein zeta/delta, 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, Serine/threonine-protein kinase B-raf 著者 Liau, N.P.D, Hymowitz, S.G, Sudhamsu, J. 登録日 2019-08-19 公開日 2019-08-28 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Negative regulation of RAF kinase activity by ATP is overcome by 14-3-3-induced dimerization. Nat.Struct.Mol.Biol., 27, 2020
4N84	Crystal structure of 14-3-3zeta in complex with a 12-carbon-linker cyclic peptide derived from ExoS 分子名称: 14-3-3 protein zeta/delta, Exoenzyme S 著者 Bier, D, Glas, A, Hahne, G, Grossmann, T, Ottmann, C. 登録日 2013-10-17 公開日 2014-02-19 最終更新日 2014-03-12 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Constrained peptides with target-adapted cross-links as inhibitors of a pathogenic protein-protein interaction. Angew.Chem.Int.Ed.Engl., 53, 2014
2V7D	14-3-3 protein zeta in complex with Thr758 phosphorylated integrin beta2 peptide 分子名称: 14-3-3 PROTEIN ZETA/DELTA, INTEGRIN BETA CHAIN, BETA 2 VARIANT 著者 Takala, H, Ylanne, J. 登録日 2007-07-30 公開日 2008-06-24 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Beta2 Integrin Phosphorylation on Thr758 Acts as a Molecular Switch to Regulate 14-3-3 and Filamin Binding. Blood, 112, 2008
6ZVC	14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 48h incubation 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide 著者 Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. 登録日 2020-07-24 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes To Be Published
6ZVB	14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 24h incubation 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide 著者 Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. 登録日 2020-07-24 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes To Be Published
6ZVE	14-3-3 Sigma in complex with phosphorylated Gab2pT391 peptide - 1h incubation 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, phosphorylated Gab2pT391 peptide 著者 Ballone, A, Lau, R.A, Zweipfenning, F.P.A, Ottmann, C. 登録日 2020-07-24 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 A new soaking procedure for X-ray crystallography structural determination of protein-peptide complexes To Be Published

<10111213141516171819202122232425>