6Y7T
Engineered conjugation of lysine-specific molecular tweezers with ExoS derived peptidic inhibitor enhance affinity towards target protein 14-3-3 through ditopic binding
Summary for 6Y7T
Entry DOI | 10.2210/pdb6y7t/pdb |
Descriptor | 14-3-3 protein sigma, Exoenzyme S, SODIUM ION, ... (6 entities in total) |
Functional Keywords | protein-protein interactions, supramolecular ligands, molecular tweezers, protein recognition, hybrid ligands, peptide binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 117195.25 |
Authors | Guillory, X.,Ottmann, C. (deposition date: 2020-03-02, release date: 2021-03-31, Last modification date: 2024-01-24) |
Primary citation | Guillory, X.,Hadrovic, I.,de Vink, P.J.,Sowislok, A.,Brunsveld, L.,Schrader, T.,Ottmann, C. Supramolecular Enhancement of a Natural 14-3-3 Protein Ligand. J.Am.Chem.Soc., 143:13495-13500, 2021 Cited by PubMed: 34427424DOI: 10.1021/jacs.1c07095 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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