6Y7T
Engineered conjugation of lysine-specific molecular tweezers with ExoS derived peptidic inhibitor enhance affinity towards target protein 14-3-3 through ditopic binding
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, F, K, P | 14-3-3 protein sigma | polymer | 253 | 28226.5 | 4 | UniProt (P31947) Pfam (PF00244) In PDB | Homo sapiens (Human) | Epithelial cell marker protein 1,Stratifin |
2 | D, E | Exoenzyme S | polymer | 11 | 1115.2 | 2 | UniProt (Q51451) UniProt (by SIFTS) (G3XDA1) In PDB | Pseudomonas aeruginosa | |
3 | A, F, K, P | SODIUM ION | non-polymer | 23.0 | 5 | Chemie (NA) | |||
4 | A, P | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
5 | D, E | ExoSTWZ molecular tweezer | non-polymer | 879.8 | 2 | Chemie (TWZ) | |||
6 | water | water | 18.0 | 367 | Chemie (HOH) |
Sequence modifications
A, F, K, P: 1 - 248 (UniProt: P31947)
PDB | External Database | Details |
---|---|---|
Gly -4 | - | expression tag |
Ala -3 | - | expression tag |
Met -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 115136.5 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 2058.7 | |
All* | Total formula weight | 117195.3 |