6PM8
| Protein Tyrosine Phosphatase 1B (1-301), P180A mutant, vanadate bound state | 分子名称: | GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION | 著者 | Cui, D.S, Lipchock, J.M, Loria, J.P. | 登録日 | 2019-07-01 | 公開日 | 2019-08-07 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B. J.Am.Chem.Soc., 141, 2019
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6KIP
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6KR4
| Crystal structure of the liprin-alpha3_SAM123/LAR_D1D2 complex | 分子名称: | HEXAETHYLENE GLYCOL, Liprin-alpha-3, PHOSPHATE ION, ... | 著者 | Xie, X, Liang, M, Luo, L, Wei, Z. | 登録日 | 2019-08-20 | 公開日 | 2020-01-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Structural basis of liprin-alpha-promoted LAR-RPTP clustering for modulation of phosphatase activity. Nat Commun, 11, 2020
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6KRX
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6KRW
| Crystal Structure of AtPTP1 at 1.4 angstrom | 分子名称: | CITRATE ANION, DI(HYDROXYETHYL)ETHER, IODIDE ION, ... | 著者 | Zhao, Y.Y, Luo, Z.P, Wang, J, Wu, J.W. | 登録日 | 2019-08-22 | 公開日 | 2020-08-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Crystal structure of AtPTP1 at 1.4 Angstroms To Be Published
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6SUB
| Human PTPRU D1 domain, reduced form | 分子名称: | CHLORIDE ION, Receptor-type tyrosine-protein phosphatase U | 著者 | Hay, I.M, Fearnley, G.W, Sharpe, H.J, Deane, J.E. | 登録日 | 2019-09-13 | 公開日 | 2020-07-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | The receptor PTPRU is a redox sensitive pseudophosphatase. Nat Commun, 11, 2020
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6SUC
| Human PTPRU D1 domain, oxidised form | 分子名称: | Receptor-type tyrosine-protein phosphatase U | 著者 | Hay, I.M, Fearnley, G.W, Sharpe, H.J, Deane, J.E. | 登録日 | 2019-09-13 | 公開日 | 2020-07-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | The receptor PTPRU is a redox sensitive pseudophosphatase. Nat Commun, 11, 2020
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6L03
| structure of PTP-MEG2 and MUNC18-1-pY145 peptide complex | 分子名称: | Tyrosine-protein phosphatase non-receptor type 9, stxbp1-pY145 peptide | 著者 | Xu, Y.F, Chen, X, Yu, X, Sun, J.P. | 登録日 | 2019-09-25 | 公開日 | 2020-09-30 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.084 Å) | 主引用文献 | PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates. Embo Rep., 22, 2021
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6KZQ
| structure of PTP-MEG2 and NSF-pY83 peptide complex | 分子名称: | NSF-pY83 peptide, Tyrosine-protein phosphatase non-receptor type 9 | 著者 | Xu, Y.F, Chen, X, Yu, X, Sun, J.P. | 登録日 | 2019-09-25 | 公開日 | 2020-09-30 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates. Embo Rep., 22, 2021
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6T36
| Crystal structure of the PTPN3 PDZ domain bound to the HBV core protein C-terminal peptide | 分子名称: | BROMIDE ION, Capsid protein, Tyrosine-protein phosphatase non-receptor type 3 | 著者 | Genera, M, Mechaly, A, Haouz, A, Caillet-Saguy, C. | 登録日 | 2019-10-10 | 公開日 | 2021-01-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein. Sci Rep, 11, 2021
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6UZT
| Crystal Structure of RPTP alpha | 分子名称: | Receptor-type tyrosine-protein phosphatase alpha | 著者 | Santelli, E, Wen, Y, Yang, S, Svensson, M.N.D, Stanford, S.M, Bottini, N. | 登録日 | 2019-11-15 | 公開日 | 2020-03-18 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | RPTP alpha phosphatase activity is allosterically regulated by the membrane-distal catalytic domain. J.Biol.Chem., 295, 2020
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6W30
| Protein Tyrosine Phosphatase 1B Bound to Amorphadiene | 分子名称: | Amorphadiene, GLYCEROL, MAGNESIUM ION, ... | 著者 | Sarkar, A, Kim, E.Y, Hongdusit, A, Sankaran, B, Fox, J. | 登録日 | 2020-03-08 | 公開日 | 2021-05-26 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Microbially Guided Discovery and Biosynthesis of Biologically Active Natural Products. Acs Synth Biol, 10, 2021
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6WU8
| Structure of human SHP2 in complex with inhibitor IACS-13909 | 分子名称: | 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Leonard, P.G, Joseph, S, Rodenberger, A. | 登録日 | 2020-05-04 | 公開日 | 2021-03-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib. Cancer Res., 80, 2020
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6WUR
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6XEA
| Crystal Structure of the PTP1B YopH WPD loop Chimera 3 bound to vanadate | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | 著者 | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | 登録日 | 2020-06-12 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.549 Å) | 主引用文献 | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XEF
| Crystal structure of the PTP1B YopH WPD loop Chimera 4 bound to vanadate | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | 著者 | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | 登録日 | 2020-06-12 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.048 Å) | 主引用文献 | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XEE
| Crystal Structure of the PTP1B YopH WPD loop Chimera 4 apo form | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, DI(HYDROXYETHYL)ETHER, ... | 著者 | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | 登録日 | 2020-06-12 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XE8
| Crystal Structure of the PTP1B YopH WPD loop Chimera 3 apo form | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | 著者 | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | 登録日 | 2020-06-12 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.952 Å) | 主引用文献 | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XED
| Crystal Structure of the PTP1B YopH WPD loop Chimera 3 bound to tungstate | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | 著者 | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | 登録日 | 2020-06-12 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.795 Å) | 主引用文献 | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XEG
| Crystal structure of the PTP1B YopH WPD loop Chimera 4 bound to tungstate | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | 著者 | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | 登録日 | 2020-06-12 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.549 Å) | 主引用文献 | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
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6XFT
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6ZZ4
| Crystal structure of the PTPN2 C216G mutant | 分子名称: | PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 2 | 著者 | Mechaly, A.E, Berthelet, J, Nian, Q, Parlato, M, Cerf-Bensussan, N, Haouz, A, Rodrigues-Lima, F. | 登録日 | 2020-08-03 | 公開日 | 2021-08-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy. Protein Sci., 31, 2022
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7JTX
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7JUK
| Crystal structure of PTEN with a tetra-phosphorylated tail (4p-crPTEN-13sp-T2, SDTTDSDPENEG) | 分子名称: | PHOSPHATE ION, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | 著者 | Dempsey, D, Phan, K, Cole, P, Gabelli, S.B. | 登録日 | 2020-08-19 | 公開日 | 2021-10-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | The structural basis of PTEN regulation by multi-site phosphorylation. Nat.Struct.Mol.Biol., 28, 2021
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7JUL
| Crystal structure of non phosphorylated PTEN (n-crPTEN-13sp-T1, SDTTDSDPENEG) | 分子名称: | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN | 著者 | Dempsey, D, Phan, K, Cole, P, Gabelli, S.B. | 登録日 | 2020-08-20 | 公開日 | 2021-08-11 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | The structural basis of PTEN regulation by multi-site phosphorylation. Nat.Struct.Mol.Biol., 28, 2021
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