6XE8

Crystal Structure of the PTP1B YopH WPD loop Chimera 3 apo form

Summary for 6XE8

Entry DOI	10.2210/pdb6xe8/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 1, BENZAMIDINE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total)
Functional Keywords	ptp1b, tyrosine phosphatase, wpd loop, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	37622.44
Authors	Olsen, K.J.,Shen, R.,Johnson, S.J.,Hengge, A.C. (deposition date: 2020-06-12, release date: 2021-12-15, Last modification date: 2023-10-25)
Primary citation	Shen, R.,Crean, R.M.,Olsen, K.J.,Corbella, M.,Calixto, A.R.,Richan, T.,Brandao, T.A.S.,Berry, R.D.,Tolman, A.,Loria, J.P.,Johnson, S.J.,Kamerlin, S.C.L.,Hengge, A.C. Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13:13524-13540, 2022 Cited by PubMed: 36507179 DOI: 10.1039/d2sc04135a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.952 Å)

Structure validation