6ZZ4

Crystal structure of the PTPN2 C216G mutant

Summary for 6ZZ4

Entry DOI	10.2210/pdb6zz4/pdb
Descriptor	Tyrosine-protein phosphatase non-receptor type 2, PHOSPHATE ION (3 entities in total)
Functional Keywords	phosphatase, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	73794.78
Authors	Mechaly, A.E.,Berthelet, J.,Nian, Q.,Parlato, M.,Cerf-Bensussan, N.,Haouz, A.,Rodrigues-Lima, F. (deposition date: 2020-08-03, release date: 2021-08-18, Last modification date: 2024-01-31)
Primary citation	Nian, Q.,Berthelet, J.,Parlato, M.,Mechaly, A.E.,Liu, R.,Dupret, J.M.,Cerf-Bensussan, N.,Haouz, A.,Rodrigues Lima, F. Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy. Protein Sci., 31:538-544, 2022 Cited by PubMed: 34806245 DOI: 10.1002/pro.4246 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.43 Å)

Structure validation