7JUK

Crystal structure of PTEN with a tetra-phosphorylated tail (4p-crPTEN-13sp-T2, SDTTDSDPENEG)

Summary for 7JUK

Entry DOI	10.2210/pdb7juk/pdb
Descriptor	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, PHOSPHATE ION (3 entities in total)
Functional Keywords	phosphatase, phosphatidylinositol 3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase pten, signaling protein, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	40981.40
Authors	Dempsey, D.,Phan, K.,Cole, P.,Gabelli, S.B. (deposition date: 2020-08-19, release date: 2021-10-13, Last modification date: 2023-10-18)
Primary citation	Dempsey, D.R.,Viennet, T.,Iwase, R.,Park, E.,Henriquez, S.,Chen, Z.,Jeliazkov, J.R.,Palanski, B.A.,Phan, K.L.,Coote, P.,Gray, J.J.,Eck, M.J.,Gabelli, S.B.,Arthanari, H.,Cole, P.A. The structural basis of PTEN regulation by multi-site phosphorylation. Nat.Struct.Mol.Biol., 28:858-868, 2021 Cited by PubMed: 34625746 DOI: 10.1038/s41594-021-00668-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.15 Å)

Structure validation