7JUK

Crystal structure of PTEN with a tetra-phosphorylated tail (4p-crPTEN-13sp-T2, SDTTDSDPENEG)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	polymer	349	40886.4	1	UniProt (P60484) Pfam (PF22785) Pfam (PF10409)	Homo sapiens (Human)	Mutated in multiple advanced cancers 1,Phosphatase and tensin homolog
2	B (A)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
3	C (A)	water	water		18.0	1	Chemie (HOH)

Sequence modifications

A: 7 - 309 (UniProt: P60484)

PDB	External Database	Details
Met 6	-	initiating methionine

A: 310 - 353 (UniProt: P60484)
A: 365 - 377 (UniProt: P60484)

PDB	External Database	Details
Thr 354	-	linker
Gly 355	-	linker
Gly 356	-	linker
Gly 357	-	linker
Ser 358	-	linker
Gly 359	-	linker
Gly 360	-	linker
Thr 361	-	linker
Gly 362	-	linker
Gly 363	-	linker
Cys 364	-	linker
Gly 378	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	40886.4
Non-Polymers*	Number of molecules	1
	Total formula weight	95.0
All*	Total formula weight	40981.4

*Water molecules are not included.