Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008285 | biological_process | negative regulation of cell population proliferation |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0016314 | molecular_function | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity |
| A | 0016791 | molecular_function | phosphatase activity |
| A | 0046856 | biological_process | phosphatidylinositol dephosphorylation |
| A | 0051717 | molecular_function | inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity |
| A | 0051800 | molecular_function | phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 A 401 |
| Chain | Residue |
| A | GLU43 |
| A | LYS332 |
| A | HOH501 |
Functional Information from PROSITE/UniProt
| site_id | PS00383 |
| Number of Residues | 11 |
| Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCkaGkgRTG |
| Chain | Residue | Details |
| A | ILE122-GLY132 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 171 |
| Details | Domain: {"description":"Phosphatase tensin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00590","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Region: {"description":"Required for interaction with NOP53","evidences":[{"source":"PubMed","id":"15355975","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00590","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"26166433","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by FRK","evidences":[{"source":"PubMed","id":"19345329","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"18716620","evidenceCode":"ECO:0000269"}]} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 456 |
| Chain | Residue | Details |
| A | ASP92 | proton shuttle (general acid/base) |
| A | CYS124 | covalent catalysis |
| A | ARG130 | transition state stabiliser |
