PDB: 10243 件ウェブページステータス検索Chemie searchBIRD

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6MSB	Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome 分子名称: 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... 著者 Mao, Y.D. 登録日 2018-10-16 公開日 2018-12-05 最終更新日 2025-05-14 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome. Nature, 565, 2019
7M2U	Nucleotide Excision Repair complex TFIIH Rad4-33 分子名称: CALCIUM ION, DNA repair helicase RAD25, DNA repair helicase RAD3, ... 著者 van Eeuwen, T, Murakami, K. 登録日 2021-03-17 公開日 2021-07-28 最終更新日 2025-05-14 実験手法 ELECTRON MICROSCOPY (8.2 Å) 主引用文献 Cryo-EM structure of TFIIH/Rad4-Rad23-Rad33 in damaged DNA opening in nucleotide excision repair. Nat Commun, 12, 2021
6MSK	Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome 分子名称: 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... 著者 Mao, Y.D. 登録日 2018-10-16 公開日 2018-11-21 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome. Nature, 565, 2019
8P7L	Cryo-EM structure of CDK7 subunit of CAK in complex with inhibitor LDC4297 分子名称: 2-[(3S)-piperidin-3-yl]oxy-8-propan-2-yl-N-[(2-pyrazol-1-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine, CDK-activating kinase assembly factor MAT1, Cyclin-dependent kinase 7 著者 Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J. 登録日 2023-05-30 公開日 2024-03-20 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (2.1 Å) 主引用文献 High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Nat Commun, 15, 2024
7UXH	cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... 著者 Cui, Z, Hurley, J. 登録日 2022-05-05 公開日 2022-11-30 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature, 614, 2023
7UXC	cryo-EM structure of the mTORC1-TFEB-Rag-Ragulator complex with symmetry expansion 分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... 著者 Cui, Z, Hurley, J. 登録日 2022-05-05 公開日 2022-11-30 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex. Nature, 614, 2023
6MSD	Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome 分子名称: 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... 著者 Mao, Y.D. 登録日 2018-10-16 公開日 2018-12-05 最終更新日 2025-05-21 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome. Nature, 565, 2019
6MSE	Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome 分子名称: 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... 著者 Mao, Y.D. 登録日 2018-10-16 公開日 2018-11-21 最終更新日 2024-11-20 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome. Nature, 565, 2019
6MSH	Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome 分子名称: 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... 著者 Mao, Y.D. 登録日 2018-10-16 公開日 2018-11-21 最終更新日 2024-11-06 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome. Nature, 565, 2019
8VNZ	PRC2_AJ1-450 bound to H3K36me3-modified nucleosome with histone H3 tail disengaged 分子名称: Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, Isoform 3 of Zinc finger protein AEBP2, ... 著者 Cookis, T, Nogales, E. 登録日 2024-01-14 公開日 2025-01-15 最終更新日 2025-05-14 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications. Nat.Struct.Mol.Biol., 32, 2025
6V92	RSC-NCP 分子名称: Actin-like protein ARP9, Actin-related protein 7, Chromatin structure-remodeling complex protein RSC14, ... 著者 Patel, A.B, Moore, C.M, Greber, B.J, Nogales, E. 登録日 2019-12-13 公開日 2020-01-15 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (20 Å) 主引用文献 Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement. Elife, 8, 2019
5LN3	The human 26S Proteasome at 6.8 Ang. 分子名称: 26S protease regulatory subunit 10B, 26S protease regulatory subunit 4, 26S protease regulatory subunit 6A, ... 著者 Schweitzer, A, Beck, F, Sakata, E, Unverdorben, P. 登録日 2016-08-03 公開日 2017-03-22 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (6.8 Å) 主引用文献 Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome. Mol. Cell Proteomics, 16, 2017
7KW7	Atomic cryoEM structure of Hsp90-Hsp70-Hop-GR 分子名称: ADENOSINE-5'-DIPHOSPHATE, Glucocorticoid receptor, Heat shock 70 kDa protein 1A, ... 著者 Wang, R.Y, Noddings, C.M, Kirschke, E, Myasnikov, A, Johnson, J.L, Agard, D.A. 登録日 2020-11-30 公開日 2021-12-08 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.57 Å) 主引用文献 Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism. Nature, 601, 2022
7RPW	Archaeal DNA ligase and heterotrimeric PCNA in complex with adenylated DNA 分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase, DNA polymerase sliding clamp 1, ... 著者 Sverzhinsky, A, Pascal, J.M. 登録日 2021-08-04 公開日 2021-11-17 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (4.38 Å) 主引用文献 Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase. Structure, 30, 2022
7RPO	Archaeal DNA ligase and heterotrimeric PCNA in complex with non-ligatable DNA 分子名称: ADENOSINE MONOPHOSPHATE, DNA ligase, DNA polymerase sliding clamp 1, ... 著者 Sverzhinsky, A, Pascal, J.M. 登録日 2021-08-03 公開日 2021-11-17 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (4.16 Å) 主引用文献 Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase. Structure, 30, 2022
7RPX	Archaeal DNA ligase and heterotrimeric PCNA in complex with end-joined DNA 分子名称: DNA ligase, DNA polymerase sliding clamp 1, DNA polymerase sliding clamp 2, ... 著者 Sverzhinsky, A, Pascal, J.M. 登録日 2021-08-04 公開日 2021-11-17 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase. Structure, 30, 2022
8PQL	K48-linked ubiquitin chain formation with a cullin-RING E3 ligase and Cdc34: NEDD8-CUL2-RBX1-ELOB/C-FEM1C with trapped UBE2R2-donor UB-acceptor UB-SIL1 peptide 分子名称: 5-azanylpentan-2-one, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... 著者 Liwocha, J, Prabu, J.R, Kleiger, G, Schulman, B.A. 登録日 2023-07-11 公開日 2024-02-14 最終更新日 2025-07-09 実験手法 ELECTRON MICROSCOPY (3.76 Å) 主引用文献 Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases. Nat.Struct.Mol.Biol., 31, 2024
8OF4	Nucleosome Bound human SIRT6 (Composite) 分子名称: DNA (145-MER), Histone H2A type 1, Histone H2B, ... 著者 Smirnova, E, Bignon, E, Schultz, P, Papai, G, Ben-Shem, A. 登録日 2023-03-13 公開日 2023-08-09 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 Binding to nucleosome poises human SIRT6 for histone H3 deacetylation. Elife, 12, 2024
9GMK	SIRT7:H3K18DTU nucleosome complex 分子名称: DNA (148-MER), Histone H2A type 2-A, Histone H2B type 1-J, ... 著者 Moreno-Yruela, C, Ekundayo, B, Foteva, P, Calvino-Sanles, E, Ni, D, Stahlberg, H, Fierz, B. 登録日 2024-08-29 公開日 2025-01-29 最終更新日 2025-07-09 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural basis of SIRT7 nucleosome engagement and substrate specificity. Nat Commun, 16, 2025
8Q7R	Ubiquitin ligation to substrate by a cullin-RING E3 ligase & Cdc34: NEDD8-CUL2-RBX1-ELOB/C-FEM1C with trapped UBE2R2~donor UB-Sil1 peptide 分子名称: 5-azanyl-1-oxidanyl-pentan-2-one, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... 著者 Liwocha, J, Prabu, J.R, Kleiger, G, Schulman, B.A. 登録日 2023-08-16 公開日 2024-02-21 最終更新日 2025-07-09 実験手法 ELECTRON MICROSCOPY (3.71 Å) 主引用文献 Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting. Mol.Cell, 84, 2024
6K1P	The complex of ISWI-nucleosome in the ADP.BeF-bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (167-MER), ... 著者 Yan, L.J, Wu, H, Li, X.M, Gao, N, Chen, Z.C. 登録日 2019-05-10 公開日 2019-05-29 最終更新日 2024-09-25 実験手法 ELECTRON MICROSCOPY (3.87 Å) 主引用文献 Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling. Nat.Struct.Mol.Biol., 26, 2019
6JYL	The crosslinked complex of ISWI-nucleosome in the ADP.BeF-bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (167-MER), ... 著者 Yan, L.J, Wu, H, Li, X.M, Gao, N, Chen, Z.C. 登録日 2019-04-26 公開日 2019-05-29 最終更新日 2024-03-27 実験手法 ELECTRON MICROSCOPY (3.37 Å) 主引用文献 Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling. Nat.Struct.Mol.Biol., 26, 2019
7X3X	Cryo-EM structure of N1 nucleosome-RA 分子名称: DNA (146-MER), Histone H2A, Histone H2B 1.1, ... 著者 Lifei, L, Kangjing, C, Chen, Z. 登録日 2022-03-01 公開日 2023-09-20 最終更新日 2025-06-25 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structure of the ISW1a complex bound to the dinucleosome. Nat.Struct.Mol.Biol., 31, 2024
7X3W	Cryo-EM structure of ISW1-N1 nucleosome 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (146-MER), ... 著者 Lifei, L, Kangjing, C, Chen, Z. 登録日 2022-03-01 公開日 2023-09-20 最終更新日 2025-06-25 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structure of the ISW1a complex bound to the dinucleosome. Nat.Struct.Mol.Biol., 31, 2024
4UVA	LSD1(KDM1A)-CoREST in complex with 1-Methyl-Tranylcypromine (1R,2S) 分子名称: LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(4aS)-4a-[(1S,3E)-3-imino-1-phenylbutyl]-7,8-dimethyl-2,4-dioxo-3,4,4a,5-tetrahydrobenzo[g]pteridin-10(2H)-yl]pentyl dihydrogen diphosphate 著者 Vianello, P, Botrugno, O, Cappa, A, Ciossani, G, Dessanti, P, Mai, A, Mattevi, A, Meroni, G, Minucci, S, Thaler, F, Tortorici, M, Trifiro, P, Valente, S, Villa, M, Varasi, M, Mercurio, C. 登録日 2014-08-05 公開日 2014-09-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A. Eur.J.Med.Chem., 86C, 2014

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