8P7L

Cryo-EM structure of CDK7 subunit of CAK in complex with inhibitor LDC4297

Summary for 8P7L

• Entry DOI: 10.2210/pdb8p7l/pdb
• Related: 8ORM
• EMDB information: 17129 17536
• Descriptor: CDK-activating kinase assembly factor MAT1, Cyclin-dependent kinase 7, 2-[(3S)-piperidin-3-yl]oxy-8-propan-2-yl-N-[(2-pyrazol-1-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine, ... (4 entities in total)
• Functional Keywords: kinase, inhibitor, transcription, cell cycle, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 80672.23

Authors

Cushing, V.I.,Koh, A.F.,Feng, J.,Jurgaityte, K.,Bahl, A.K.,Ali, S.,Kotecha, A.,Greber, B.J. (deposition date: 2023-05-30, release date: 2024-03-20, Last modification date: 2024-03-27)

• Primary citation: Cushing, V.I.,Koh, A.F.,Feng, J.,Jurgaityte, K.,Bondke, A.,Kroll, S.H.B.,Barbazanges, M.,Scheiper, B.,Bahl, A.K.,Barrett, A.G.M.,Ali, S.,Kotecha, A.,Greber, B.J.; High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.; Nat Commun, 15:2265-2265, 2024; PubMed: 38480681; DOI: 10.1038/s41467-024-46375-9

Experimental method

ELECTRON MICROSCOPY (2.1 Å)