PDB: 610 件ウェブページステータス検索Chemie searchBIRD

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7O1W	X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 2 (mi307) soaked at 1 M NaCl 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... 著者 Dahms, S.O, Brandstetter, H. 登録日 2021-03-30 公開日 2021-09-01 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 OFF-State-Specific Inhibition of the Proprotein Convertase Furin. Acs Chem.Biol., 16, 2021
7O20	X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 3 (mi300) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... 著者 Dahms, S.O, Brandstetter, H. 登録日 2021-03-30 公開日 2021-09-01 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 OFF-State-Specific Inhibition of the Proprotein Convertase Furin. Acs Chem.Biol., 16, 2021
6XID	PCSK9(deltaCRD) in complex with cyclic peptide 51 分子名称: GLYCEROL, Peptide 51, Proprotein convertase subtilisin/kexin type 9 著者 Orth, P. 登録日 2020-06-19 公開日 2020-11-18 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (1.482 Å) 主引用文献 Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design. J.Med.Chem., 63, 2020
6YD2	X-ray structure of furin in complex with the canavanine-based inhibitor 4-aminomethyl-phenylacetyl-canavanine-Tle-Arg-Amba 分子名称: 4-aminomethyl-phenylacetyl-canavanine-Tle-Arg-Amba, CALCIUM ION, CHLORIDE ION, ... 著者 Dahms, S.O. 登録日 2020-03-20 公開日 2021-02-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The Basicity Makes the Difference: Improved Canavanine-Derived Inhibitors of the Proprotein Convertase Furin. Acs Med.Chem.Lett., 12, 2021
6XIF	PCSK9(deltaCRD) in complex with cyclic peptide 83 分子名称: GLYCEROL, Peptide 83, Proprotein convertase subtilisin/kexin type 9 著者 Orth, P. 登録日 2020-06-19 公開日 2020-11-18 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.774 Å) 主引用文献 Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design. J.Med.Chem., 63, 2020
6XIE	PCSK9(deltaCRD) in complex with cyclic peptide 77 分子名称: GLYCEROL, Peptide 77, Proprotein convertase subtilisin/kexin type 9 著者 Orth, P. 登録日 2020-06-19 公開日 2020-11-18 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design. J.Med.Chem., 63, 2020
6XIB	PCSK9(deltaCRD) in complex with cyclic peptide 30 分子名称: GLYCEROL, Peptide 30, Proprotein convertase subtilisin/kexin type 9 著者 Orth, P. 登録日 2020-06-19 公開日 2020-11-18 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (1.546 Å) 主引用文献 Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design. J.Med.Chem., 63, 2020
6XIC	PCSK9(deltaCRD) in complex with cyclic peptide 40 分子名称: GLYCEROL, Peptide 40, Proprotein convertase subtilisin/kexin type 9 著者 Orth, P. 登録日 2020-06-19 公開日 2020-11-18 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (1.377 Å) 主引用文献 Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design. J.Med.Chem., 63, 2020
3I74	Crystal Structure of the plant subtilisin-like protease SBT3 in complex with a chloromethylketone inhibitor 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACE-PHE-GLU-LYS-ALA chloromethylketone INHIBITOR, Subtilisin-like protease, ... 著者 Rose, R, Ottmann, C. 登録日 2009-07-08 公開日 2010-01-19 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3. Proc.Natl.Acad.Sci.USA, 106, 2009
4LVN	Crystal structure of PfSUB1-prodomain-NIMP.M7 Fab complex 分子名称: CALCIUM ION, NICKEL (II) ION, NIMP.M7 Fab heavy chain, ... 著者 Withers-Martinez, C, Blackman, M.J. 登録日 2013-07-26 公開日 2014-05-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin. Nat Commun, 5, 2014
7QY2	X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 2 分子名称: (2R)-4-[4-[5-[4-[[4-(acetamidomethyl)piperidin-1-ium-1-yl]methyl]-6-[3,5-bis(chloranyl)phenyl]pyridin-2-yl]oxypyrimidin-2-yl]piperazin-1-ium-1-yl]-2-methyl-butanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Dahms, S.O, Brandstetter, H, Pautsch, A. 登録日 2022-01-27 公開日 2022-04-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism. Acs Chem.Biol., 17, 2022
7QXZ	X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 5 分子名称: 2-[(3S)-1-[[2-[3,5-bis(chloranyl)phenyl]-6-[2-(4-methylpiperazin-4-ium-1-yl)pyrimidin-5-yl]oxy-pyridin-4-yl]methyl]pyrrolidin-1-ium-3-yl]oxyethanoic acid, CALCIUM ION, CHLORIDE ION, ... 著者 Dahms, S.O, Brandstetter, H, Pautsch, A. 登録日 2022-01-27 公開日 2022-04-13 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism. Acs Chem.Biol., 17, 2022
7QXY	X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 3 分子名称: 3-[4-[5-[4-[[4-(acetamidomethyl)piperidin-1-ium-1-yl]methyl]-6-[3,5-bis(chloranyl)phenyl]pyridin-2-yl]oxypyrimidin-2-yl]piperazin-1-ium-1-yl]propanoate, CALCIUM ION, CHLORIDE ION, ... 著者 Dahms, S.O, Brandstetter, H, Pautsch, A. 登録日 2022-01-27 公開日 2022-04-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.478 Å) 主引用文献 Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism. Acs Chem.Biol., 17, 2022
7QY0	X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... 著者 Dahms, S.O, Brandstetter, H, Pautsch, A. 登録日 2022-01-27 公開日 2022-04-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism. Acs Chem.Biol., 17, 2022
7QY1	X-ray structure of furin in complex with the dichlorophenylpyridine-based inhibitor 4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[4-[5-[4-[[4-(acetamidomethyl)piperidin-1-ium-1-yl]methyl]-6-[3,5-bis(chloranyl)phenyl]pyridin-2-yl]oxypyridin-2-yl]piperazin-1-ium-1-yl]propanoate, CALCIUM ION, ... 著者 Dahms, S.O, Brandstetter, H, Pautsch, A. 登録日 2022-01-27 公開日 2022-04-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Dichlorophenylpyridine-Based Molecules Inhibit Furin through an Induced-Fit Mechanism. Acs Chem.Biol., 17, 2022
6HZA	X-ray structure of furin in complex with the cyclic peptide c[glutaryl-Arg-Arg-Lys]-Arg-4-Amba 分子名称: ARG-ARG-LYS-ARG-00S, CALCIUM ION, CHLORIDE ION, ... 著者 Dahms, S.O. 登録日 2018-10-23 公開日 2019-02-06 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. Chemmedchem, 14, 2019
6HLB	X-ray structure of furin in complex with the cyclic peptide c[succinyl-Phe-2-Nal-(Arg)4-Lys]-Arg-4-Amba 分子名称: CALCIUM ION, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Dahms, S.O. 登録日 2018-09-11 公開日 2019-02-06 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. Chemmedchem, 14, 2019
6HLE	X-ray structure of furin in complex with the P6-P2-cyclized peptide H-Lys-Arg-Arg-Tle-Lys-4-Amba 分子名称: 3-[4-(3-oxidanylidenepropyl)piperazin-1-yl]propanal, CALCIUM ION, CHLORIDE ION, ... 著者 Dahms, S.O. 登録日 2018-09-11 公開日 2019-02-06 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.994 Å) 主引用文献 Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. Chemmedchem, 14, 2019
6HZD	X-ray structure of furin in complex with the cyclic inhibitor c[glutaryl-Arg-Arg-Arg-Lys]-Arg-4-Amba 分子名称: ARG-ARG-ARG-LYS-ARG-00S, CALCIUM ION, CHLORIDE ION, ... 著者 Dahms, S.O. 登録日 2018-10-23 公開日 2019-02-06 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. Chemmedchem, 14, 2019
6HZB	X-ray structure of furin in complex with the cyclic inhibitor c[glutaryl-Arg-Arg-Lys]-Lys-4-Amba 分子名称: ARG-ARG-LYS-LYS-00S, CALCIUM ION, CHLORIDE ION, ... 著者 Dahms, S.O. 登録日 2018-10-23 公開日 2019-02-06 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. Chemmedchem, 14, 2019
6HZC	X-ray structure of furin in complex with the cyclic inhibitor c[glutaryl-BVK-Lys-Arg-Arg-Tle-Lys]-4-Amba 分子名称: 2-[4-(aminomethyl)phenyl]ethanoic acid, CALCIUM ION, CHLORIDE ION, ... 著者 Dahms, S.O. 登録日 2018-10-23 公開日 2019-02-06 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. Chemmedchem, 14, 2019
4NE9	PCSK9 in complex with LDLR peptide 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Low-density lipoprotein receptor, ... 著者 Liu, S. 登録日 2013-10-28 公開日 2014-09-10 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro. Chem.Biol., 21, 2014
8GKO	Crystal Structure Analysis of Aspergillus fumigatus alkaline protease 分子名称: 1,2-ETHANEDIOL, Alkaline protease 1, FORMYL GROUP, ... 著者 Fernandez, D, Diec, D.D.L, Guo, W, Russi, S. 登録日 2023-03-20 公開日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.06 Å) 主引用文献 Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision. Sci Rep, 13, 2023
8GKP	Crystal Structure Analysis of Aspergillus fumigatus alkaline protease 分子名称: Alkaline protease 1, DI(HYDROXYETHYL)ETHER, FORMIC ACID, ... 著者 Fernandez, D, Diec, D.D.L, Guo, W, Russi, S. 登録日 2023-03-20 公開日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision. Sci Rep, 13, 2023
8GKQ	Crystal Structure Analysis of Aspergillus fumigatus alkaline protease 分子名称: 1,2-ETHANEDIOL, Alkaline protease 1, CALCIUM ION, ... 著者 Fernandez, D, Diec, D.D.L, Guo, W, Russi, S. 登録日 2023-03-20 公開日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision. Sci Rep, 13, 2023

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