6HZA

X-ray structure of furin in complex with the cyclic peptide c[glutaryl-Arg-Arg-Lys]-Arg-4-Amba

Summary for 6HZA

DescriptorFurin, ARG-ARG-LYS-ARG-00S, CALCIUM ION, ... (9 entities in total)
Functional Keywordsprotease proprotein convertase inhibitor complex cyclic peptide, hydrolase
Biological sourceHomo sapiens (Human)
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Total number of polymer chains2
Total molecular weight53731.4
Authors
Dahms, S.O. (deposition date: 2018-10-23, release date: 2019-02-06, Last modification date: 2019-04-03)
Primary citation
Van Lam van, T.,Ivanova, T.,Hardes, K.,Heindl, M.R.,Morty, R.E.,Bottcher-Friebertshauser, E.,Lindberg, I.,Than, M.E.,Dahms, S.O.,Steinmetzer, T.
Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin.
Chemmedchem, 14:673-685, 2019
PubMed: 30680958 (PDB entries with the same primary citation)
DOI: 10.1002/cmdc.201800807
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.18610 0.8% 2.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6hza
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Molmil generated image of 6hza
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Molmil generated image of 6hza
rotated about y axis by 90°