6HLB

X-ray structure of furin in complex with the cyclic peptide c[succinyl-Phe-2-Nal-(Arg)4-Lys]-Arg-4-Amba

Summary for 6HLB

DescriptorFurin, PHE-(ALN)-ARG-ARG-ARG-ARG-SLL-ARG-00S, CALCIUM ION, ... (8 entities in total)
Functional Keywordsprotease proprotein convertase inhibitor complex cyclic peptide, hydrolase
Biological sourceHomo sapiens (Human)
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Total number of polymer chains2
Total molecular weight54389.15
Authors
Dahms, S.O. (deposition date: 2018-09-11, release date: 2019-02-06, Last modification date: 2019-04-03)
Primary citation
Van Lam van, T.,Ivanova, T.,Hardes, K.,Heindl, M.R.,Morty, R.E.,Bottcher-Friebertshauser, E.,Lindberg, I.,Than, M.E.,Dahms, S.O.,Steinmetzer, T.
Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin.
Chemmedchem, 14:673-685, 2019
PubMed: 30680958 (PDB entries with the same primary citation)
DOI: 10.1002/cmdc.201800807
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.18700 1.3% 1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution