X-ray structure of furin in complex with the P6-P2-cyclized peptide H-Lys-Arg-Arg-Tle-Lys-4-Amba

Summary for 6HLE

DescriptorFurin, LYS-ARG-ARG-TBG-LYS-00S, CALCIUM ION, ... (9 entities in total)
Functional Keywordsprotease proprotein convertase inhibitor complex cyclic peptide, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight53914.69
Dahms, S.O. (deposition date: 2018-09-11, release date: 2019-02-06, Last modification date: 2019-04-03)
Primary citation
Van Lam van, T.,Ivanova, T.,Hardes, K.,Heindl, M.R.,Morty, R.E.,Bottcher-Friebertshauser, E.,Lindberg, I.,Than, M.E.,Dahms, S.O.,Steinmetzer, T.
Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin.
Chemmedchem, 14:673-685, 2019
PubMed: 30680958 (PDB entries with the same primary citation)
DOI: 10.1002/cmdc.201800807
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.19110 1.6% 3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution