6HLE
X-ray structure of furin in complex with the P6-P2-cyclized peptide H-Lys-Arg-Arg-Tle-Lys-4-Amba
Summary for 6HLE
Entry DOI | 10.2210/pdb6hle/pdb |
Descriptor | Furin, LYS-ARG-ARG-TBG-LYS-00S, CALCIUM ION, ... (9 entities in total) |
Functional Keywords | protease proprotein convertase inhibitor complex cyclic peptide, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 53914.69 |
Authors | Dahms, S.O. (deposition date: 2018-09-11, release date: 2019-02-06, Last modification date: 2024-01-24) |
Primary citation | Van Lam van, T.,Ivanova, T.,Hardes, K.,Heindl, M.R.,Morty, R.E.,Bottcher-Friebertshauser, E.,Lindberg, I.,Than, M.E.,Dahms, S.O.,Steinmetzer, T. Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin. Chemmedchem, 14:673-685, 2019 Cited by PubMed: 30680958DOI: 10.1002/cmdc.201800807 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.994 Å) |
Structure validation
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