8COE
| complement C5 in complex with the LCP0195 nanobody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5 alpha chain, Complement C5 beta chain, ... | 著者 | Andersen, G.R, Pedersen, D.V. | 登録日 | 2023-02-28 | 公開日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration. Mol.Immunol., 165, 2023
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7VOO
| Induced alpha-2-macroglobulin monomer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | 著者 | Huang, X, Wang, Y, Ping, Z. | 登録日 | 2021-10-14 | 公開日 | 2022-10-19 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor. Sci China Life Sci, 65, 2022
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2ICF
| CRIg bound to C3b | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C3 alpha chain, ... | 著者 | Wiesmann, C. | 登録日 | 2006-09-12 | 公開日 | 2006-11-07 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (4.1 Å) | 主引用文献 | Structure of C3b in complex with CRIg gives insights into regulation of complement activation. Nature, 444, 2006
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4E0S
| Crystal Structure of C5b-6 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C5, ... | 著者 | Aleshin, A.E, Stec, B, DiScipio, R, Liddington, R.C. | 登録日 | 2012-03-05 | 公開日 | 2012-04-18 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (4.21 Å) | 主引用文献 | Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex. J.Biol.Chem., 287, 2012
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6YO6
| Structure of iC3b1 | 分子名称: | hC3Nb1, iC3b1 alpha chain, iC3b1 beta chain | 著者 | Jensen, R.K, Andersen, G.R. | 登録日 | 2020-04-14 | 公開日 | 2021-02-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (6 Å) | 主引用文献 | Complement Receptor 3 Forms a Compact High-Affinity Complex with iC3b. J Immunol., 206, 2021
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4D94
| Crystal Structure of TEP1r | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Le, B.V, Williams, M, Logarajah, S, Baxter, R.H.G. | 登録日 | 2012-01-11 | 公開日 | 2012-10-17 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Molecular Basis for Genetic Resistance of Anopheles gambiae to Plasmodium: Structural Analysis of TEP1 Susceptible and Resistant Alleles. Plos Pathog., 8, 2012
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5NBQ
| The structure of the tripartite complex between OspE, the C-terminal domains of factor H and C3dg | 分子名称: | Complement C3, Complement factor H, Outer surface protein E, ... | 著者 | Kolodziejczyk, R, Mikula, K.M, Kotila, T.M, Postis, V.L.G, Sakari, J.T, Meri, T. | 登録日 | 2017-03-02 | 公開日 | 2017-12-06 | 最終更新日 | 2017-12-13 | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | 主引用文献 | Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi. PLoS ONE, 12, 2017
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8OQ3
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1GHQ
| CR2-C3D COMPLEX STRUCTURE | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, COMPLEMENT C3, CR2/CD121/C3D/EPSTEIN-BARR VIRUS RECEPTOR, ... | 著者 | Szakonyi, G, Guthridge, J.M, Li, D, Holers, V.M, Chen, X.S. | 登録日 | 2001-01-11 | 公開日 | 2001-06-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Structure of complement receptor 2 in complex with its C3d ligand. Science, 292, 2001
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6YSQ
| The hC4Nb8 complement inhibitory nanobody in complex with C4b | 分子名称: | Complement C4 beta chain, Complement C4 gamma chain, Complement C4-A alpha chain, ... | 著者 | Zarantonello, A, Laursen, N.S, Andersen, G.R. | 登録日 | 2020-04-23 | 公開日 | 2020-06-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase. J Immunol., 205, 2020
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8OVB
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7VON
| Native alpha-2-macroglobulin monomer | 分子名称: | Alpha-2-macroglobulin | 著者 | Huang, X, Wang, Y. | 登録日 | 2021-10-14 | 公開日 | 2022-11-16 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | 主引用文献 | Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor. Sci China Life Sci, 65, 2022
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8ENU
| Structure of the C3bB proconvertase in complex with lufaxin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | 著者 | Andersen, J.F, Lei, H. | 登録日 | 2022-09-30 | 公開日 | 2023-08-09 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism. Blood, 141, 2023
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7TV9
| HUMAN COMPLEMENT COMPONENT C3B IN COMPLEX WITH APL-1030 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, APL-1030 Nanofitin, Complement C3 beta chain, ... | 著者 | Fontano, E, Nadupalli, A, Lakshminarasimhan, D, White, A, Garlish, J, Cinier, M, Chevrel, A, Perrocheau, A, Eyerman, D, Orme, M, Kitten, O, Scheibler, L. | 登録日 | 2022-02-04 | 公開日 | 2022-03-30 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Discovery of APL-1030, a Novel, High-Affinity Nanofitin Inhibitor of C3-Mediated Complement Activation. Biomolecules, 12, 2022
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2PN5
| Crystal Structure of TEP1r | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ... | 著者 | Baxter, R.H.G. | 登録日 | 2007-04-23 | 公開日 | 2007-07-24 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.698 Å) | 主引用文献 | Structural basis for conserved complement factor-like function in the antimalarial protein TEP1 Proc.Natl.Acad.Sci.Usa, 104, 2007
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8EOK
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5O35
| Structure of complement proteins complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, Complement factor H,Complement factor H | 著者 | Xue, X, Wu, J, Forneris, F, Gros, P. | 登録日 | 2017-05-23 | 公開日 | 2017-06-28 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (4.2 Å) | 主引用文献 | Regulator-dependent mechanisms of C3b processing by factor I allow differentiation of immune responses. Nat. Struct. Mol. Biol., 24, 2017
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2I07
| Human Complement Component C3b | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3b, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Janssen, B.J.C, Christodoulidou, A, McCarthy, A, Lambris, J.D, Gros, P. | 登録日 | 2006-08-10 | 公開日 | 2006-10-24 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | Structure of C3b reveals conformational changes that underlie complement activity. Nature, 444, 2006
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7S64
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7S63
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7S62
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3CU7
| Human Complement Component 5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, ... | 著者 | Fredslund, F, Andersen, G.R. | 登録日 | 2008-04-16 | 公開日 | 2008-06-10 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.105 Å) | 主引用文献 | Structure of and influence of a tick complement inhibitor on human complement component 5 Nat.Immunol., 9, 2008
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6EHG
| complement component C3b in complex with a nanobody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Jensen, R.K, Andersen, K.R, Gadeberg, T.A.F, Laursen, N.S, Andersen, G.R. | 登録日 | 2017-09-13 | 公開日 | 2018-02-14 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement. J. Biol. Chem., 293, 2018
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4LNV
| Crystal Structure of TEP1s | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Thioester-containing protein I | 著者 | Le, B.V, Williams, M, Logarajah, S, Baxter, R.H.G. | 登録日 | 2013-07-12 | 公開日 | 2013-07-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Molecular basis for genetic resistance of Anopheles gambiae to Plasmodium: structural analysis of TEP1 susceptible and resistant alleles. Plos Pathog., 8, 2012
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5JPM
| Structure of the complex of human complement C4 with MASP-2 rebuilt using iMDFF | 分子名称: | Complement C4-A, Mannan-binding lectin serine protease 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Croll, T.I, Andersen, G.R. | 登録日 | 2016-05-03 | 公開日 | 2016-08-10 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.75 Å) | 主引用文献 | Re-evaluation of low-resolution crystal structures via interactive molecular-dynamics flexible fitting (iMDFF): a case study in complement C4. Acta Crystallogr D Struct Biol, 72, 2016
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