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4F3T
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Human Argonaute-2 - miR-20a complex
分子名称: PHENOL, Protein argonaute-2, RNA (5'-R(P*UP*AP*AP*AP*GP*UP*GP*CP*UP*UP*AP*UP*AP*GP*UP*G*CP*AP*GP*G)-3')
著者Elkayam, E, Kuhn, C.-D, Tocilj, A, Joshua-Tor, L.
登録日2012-05-09
公開日2012-05-30
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献The Structure of Human Argonaute-2 in Complex with miR-20a.
Cell(Cambridge,Mass.), 150, 2012
1U04
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BU of 1u04 by Molmil
Crystal structure of full length Argonaute from Pyrococcus furiosus
分子名称: hypothetical protein PF0537
著者Song, J.J, Smith, S.K, Hannon, G.J, Joshua-Tor, L.
登録日2004-07-12
公開日2004-08-17
最終更新日2021-10-27
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity
Science, 305, 2004
6D8A
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BU of 6d8a by Molmil
RsAgo Ternary Complex with guide RNA and Target DNA Containing A-A Bulge Within the Seed Segment of the Target Strand
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, DNA (5'-D(P*TP*CP*GP*TP*CP*AP*CP*CP*TP*GP*TP*GP*CP*AP*GP*AP*AP*TP*AP*AP*C)-3'), ...
著者Liu, Y, Esyunina, D, Olovnikov, I, Teplova, M, Patel, D.J.
登録日2018-04-26
公開日2018-07-25
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.251 Å)
主引用文献Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Cell Rep, 24, 2018
5G5S
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BU of 5g5s by Molmil
Structure of the Argonaute protein from Methanocaldcoccus janaschii
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ARGONAUTE, MAGNESIUM ION
著者Schneider, S, Oellig, C.A, Keegan, R, Grohmann, D, Zander, A, Willkomm, S.
登録日2016-06-03
公開日2017-02-08
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein.
Nat Microbiol, 2, 2017
4KXT
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BU of 4kxt by Molmil
Structure of human ARGONAUTE1 in complex with guide RNA
分子名称: Protein argonaute-1, RNA
著者Nakanishi, K, Patel, D.J.
登録日2013-05-28
公開日2013-07-31
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.294 Å)
主引用文献Eukaryote-Specific Insertion Elements Control Human ARGONAUTE Slicer Activity.
Cell Rep, 3, 2013
4OLA
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BU of 4ola by Molmil
Crystal Structure of Human Argonaute2
分子名称: 5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*U)-3', ISOPROPYL ALCOHOL, PHENOL, ...
著者Schirle, N.T, MacRae, I.J.
登録日2014-01-23
公開日2014-02-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The crystal structure of human Argonaute2.
Science, 336, 2012
4Z4C
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BU of 4z4c by Molmil
Human Argonaute2 Bound to t1-C Target RNA
分子名称: ISOPROPYL ALCOHOL, MAGNESIUM ION, PHENOL, ...
著者Schirle, N.T, MacRae, I.J.
登録日2015-04-02
公開日2015-09-23
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.303 Å)
主引用文献Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets.
Elife, 4, 2015
5GUH
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BU of 5guh by Molmil
Crystal structure of silkworm PIWI-clade Argonaute Siwi bound to piRNA
分子名称: MAGNESIUM ION, PIWI, RNA (28-MER)
著者Matsumoto, N, Nishimasu, H, Ishitani, R, Nureki, O.
登録日2016-08-29
公開日2016-10-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA
Cell, 167, 2016
4KPY
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BU of 4kpy by Molmil
DNA binding protein and DNA complex structure
分子名称: DNA (5'-D(*TP*AP*TP*AP*CP*AP*AP*CP*C)-3'), DNA (5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), ...
著者Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y.
登録日2013-05-14
公開日2014-01-29
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.406 Å)
主引用文献Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
4NCA
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BU of 4nca by Molmil
Structure of Thermus thermophilus Argonaute bound to guide DNA 19-mer and target DNA in the presence of Mg2+
分子名称: 5'-D(*AP*CP*AP*AP*CP*C)-3', 5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', ...
著者Sheng, G, Zhao, H, Wang, J, Rao, Y, Wang, Y.
登録日2013-10-24
公開日2014-01-15
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.489 Å)
主引用文献Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
5JS1
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BU of 5js1 by Molmil
Human Argonaute2 Bound to an siRNA
分子名称: MAGNESIUM ION, PHENOL, Protein argonaute-2, ...
著者Schirle, N.T, MacRae, I.J.
登録日2016-05-07
公開日2016-07-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.499 Å)
主引用文献Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide.
J.Am.Chem.Soc., 138, 2016
4W5T
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BU of 4w5t by Molmil
The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-7
分子名称: MAGNESIUM ION, PHENOL, Protein argonaute-2, ...
著者Schirle, N.T, MacRae, I.J.
登録日2014-08-18
公開日2014-11-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Gene regulation. Structural basis for microRNA targeting.
Science, 346, 2014
4W5R
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BU of 4w5r by Molmil
The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8 (Long Target)
分子名称: ISOPROPYL ALCOHOL, MAGNESIUM ION, PHENOL, ...
著者Schirle, N.T, MacRae, I.J.
登録日2014-08-18
公開日2014-11-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Gene regulation. Structural basis for microRNA targeting.
Science, 346, 2014
6MFN
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BU of 6mfn by Molmil
Human Argonaute2-miR-27a bound to HSUR1 target RNA
分子名称: PHENOL, Protein argonaute-2, RNA (5'-R(P*UP*CP*UP*GP*UP*GP*AP*UP*AP*A)-3'), ...
著者Sheu-Gruttadauria, J, MacRae, I.J.
登録日2018-09-11
公開日2019-08-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Basis for Target-Directed MicroRNA Degradation.
Mol.Cell, 75, 2019
8D71
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BU of 8d71 by Molmil
Human Ago2 bound to miR122(21nt)
分子名称: MAGNESIUM ION, Protein argonaute-2, miR-122-21nt
著者Xiao, Y, MacRae, I.
登録日2022-06-07
公開日2023-05-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength.
Embo Rep., 24, 2023
8D6J
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BU of 8d6j by Molmil
Human Ago2 bound to miR122(21nt) with PIWI loop swapped to AtAgo10 sequence
分子名称: MAGNESIUM ION, Protein argonaute-2, RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3')
著者Xiao, Y, MacRae, I.
登録日2022-06-06
公開日2023-05-03
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength.
Embo Rep., 24, 2023
1YTU
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BU of 1ytu by Molmil
Structural basis for 5'-end-specific recognition of the guide RNA strand by the A. fulgidus PIWI protein
分子名称: 5'-R(P*AP*GP*AP*CP*AP*G)-3', 5'-R(P*UP*GP*UP*C)-3', MAGNESIUM ION, ...
著者Ma, J.B, Yuan, Y.R, Meister, G, Pei, Y, Tuschl, T, Patel, D.J.
登録日2005-02-11
公開日2005-04-05
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein.
Nature, 434, 2005
1Z26
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BU of 1z26 by Molmil
Structure of Pyrococcus furiosus Argonaute with bound tungstate
分子名称: Argonaute, TUNGSTATE(VI)ION
著者Rivas, F.V, Tolia, N.H, Song, J.J, Aragon, J.P, Liu, J, Hannon, G.J, Joshua-Tor, L.
登録日2005-03-07
公開日2005-04-05
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Purified Argonaute2 and an siRNA form recombinant human RISC.
Nat.Struct.Mol.Biol., 12, 2005
8OK9
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BU of 8ok9 by Molmil
Heterodimeric complex of Archaeoglobus fulgidus Argonaute protein Af1318 (AfAgo) with DNA and AfAgo-N protein containing N-L1-L2 domains
分子名称: 1,2-ETHANEDIOL, ACETIC ACID, Archaeoglobus fulgidus AfAgo-N protein, ...
著者Manakova, E.N, Zaremba, M.
登録日2023-03-27
公開日2024-01-24
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The missing part: the Archaeoglobus fulgidus Argonaute forms a functional heterodimer with an N-L1-L2 domain protein.
Nucleic Acids Res., 52, 2024
4Z4H
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BU of 4z4h by Molmil
Human Argonaute2 A481T Mutant Bound to t1-A Target RNA
分子名称: MAGNESIUM ION, PHENOL, Protein argonaute-2, ...
著者Schirle, N.T, MacRae, I.J.
登録日2015-04-02
公開日2015-09-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.504 Å)
主引用文献Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets.
Elife, 4, 2015
5T7B
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BU of 5t7b by Molmil
Argonaute-2 - 5'-(E)-vinylphosphonate 2'-O-methyl-uridine modified mrTTR guide RNA complex
分子名称: PHENOL, Protein argonaute-2, RNA (UVP)UAUAGAGCAAGAACACUGUU
著者Elkayam, E, Joshua-Tor, L.
登録日2016-09-02
公開日2016-12-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.529 Å)
主引用文献Protein structure
To Be Published
3HO1
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BU of 3ho1 by Molmil
Crystal structure of T. thermophilus Argonaute N546 mutant protein complexed with DNA guide strand and 12-nt RNA target strand
分子名称: 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*T*AP*GP*T)-3', 5'-R(P*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', MAGNESIUM ION, ...
著者Wang, Y, Li, H, Sheng, G, Patel, D.J.
登録日2009-06-01
公開日2009-10-06
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
6D9L
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BU of 6d9l by Molmil
Ternary RsAgo Complex with Guide RNA and Target DNA Containing G-A Non-canonical Pair
分子名称: DNA (5'-D(P*TP*CP*GP*TP*CP*AP*CP*CP*TP*GP*AP*GP*CP*AP*GP*TP*AP*AP*C)-3'), MAGNESIUM ION, RNA (5'-R(P*UP*UP*AP*CP*UP*GP*CP*GP*CP*AP*GP*GP*UP*GP*AP*CP*GP*A)-3'), ...
著者Liu, Y, Esyunina, D, Olovnikov, I, Teplova, M, Patel, D.J.
登録日2018-04-30
公開日2018-07-25
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Cell Rep, 24, 2018
5XOU
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Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 7T8 on the guide strand
分子名称: DNA (5'-D(*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*TP*GP*GP*TP*TP*GP*T)-3'), MAGNESIUM ION, ...
著者Sheng, G, Wang, J, Zhao, H, Wang, Y.
登録日2017-05-31
公開日2017-10-04
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Nucleic Acids Res., 45, 2017
5GQ9
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Crystal structure of Thermus thermophilus Argonaute in complex with g1C siDNA and DNA target
分子名称: DNA (5'-D(P*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), DNA (5'-D(P*CP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3'), MAGNESIUM ION, ...
著者Zhao, H, Sheng, G, Wang, Y.
登録日2016-08-06
公開日2017-08-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of Thermus thermophilus Argonaute in complex with g1C siDNA and DNA target
To Be Published

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