PDB: 473 件ウェブページステータス検索Chemie searchBIRD

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3SE9	Crystal structure of broadly and potently neutralizing antibody VRC-PG04 in complex with HIV-1 gp120 分子名称: (R,R)-2,3-BUTANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kwong, P.D, Zhou, T. 登録日 2011-06-10 公開日 2011-08-10 最終更新日 2021-04-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science, 333, 2011
3SE8	Crystal structure of broadly and potently neutralizing antibody VRC03 in complex with HIV-1 gp120 分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kwong, P.D, Zhou, T. 登録日 2011-06-10 公開日 2011-08-10 最終更新日 2021-04-07 実験手法 X-RAY DIFFRACTION (1.895 Å) 主引用文献 Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science, 333, 2011
3TGR	Crystal structure of unliganded HIV-1 clade C strain C1086 gp120 core 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 clade C1086 gp120 著者 Kwon, Y.D, Kwong, P.D. 登録日 2011-08-17 公開日 2012-04-04 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops. Proc.Natl.Acad.Sci.USA, 109, 2012
3TGT	Crystal structure of unliganded HIV-1 clade A/E strain 93TH057 gp120 core 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HIV-1 clade A/E 93TH057 gp120 著者 Kwon, Y.D, Kwong, P.D. 登録日 2011-08-17 公開日 2012-04-04 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops. Proc.Natl.Acad.Sci.USA, 109, 2012
3TGQ	Crystal structure of unliganded HIV-1 clade B strain YU2 gp120 core 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 YU2 gp120 著者 Kwon, Y.D, Kwong, P.D. 登録日 2011-08-17 公開日 2012-04-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops. Proc.Natl.Acad.Sci.USA, 109, 2012
3TGS	Crystal structure of HIV-1 clade C strain C1086 gp120 core in complex with NBD-556 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 clade C1086 gp120 core, N-(4-chlorophenyl)-N'-(2,2,6,6-tetramethylpiperidin-4-yl)ethanediamide 著者 Kwon, Y.D, Kwong, P.D. 登録日 2011-08-17 公開日 2012-04-04 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops. Proc.Natl.Acad.Sci.USA, 109, 2012
5CD5	Crystal structure of an immature VRC01-class antibody DRVIA7 from a Chinese donor bound to clade A/E HIV-1 gp120 core 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 93TH057 HIV-1 gp120 core, ... 著者 Kong, L, Wilson, I.A. 登録日 2015-07-03 公開日 2016-04-06 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.396 Å) 主引用文献 Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor. Immunity, 44, 2016
8SXJ	CH505 Disulfide Stapled SOSIP Bound to CH235.12 Fab 分子名称: CH235.12 Heavy Chain, CH235.12 Light Chain, Envelope glycoprotein gp160, ... 著者 Henderson, R. 登録日 2023-05-22 公開日 2024-02-14 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Microsecond dynamics control the HIV-1 Envelope conformation. Sci Adv, 10, 2024
7N8Q	Rhesusized RV305 DH677.3 Fab bound to Clade A/E 93TH057 HIV-1 gp120 core. 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, M48U1 CD4 MIMETIC PEPTIDE, Rhesusized DH677.3 FAB HEAVY CHAIN, ... 著者 Tolbert, W.D, Pazgier, M. 登録日 2021-06-15 公開日 2022-04-06 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure and Fc-Effector Function of Rhesusized Variants of Human Anti-HIV-1 IgG1s. Front Immunol, 12, 2021
7TJP	HIV-1 gp120 complex with CJF-II-195 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, IMIDAZOLE, ... 著者 Gong, Z, Hendrickson, W.A. 登録日 2022-01-16 公開日 2023-01-25 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 Structural and Functional Characterization of Indane-Core CD4-Mimetic Compounds Substituted with Heterocyclic Amines Acs Medicinal Chemistry Letters, 14, 2023
7TJO	HIV-1 gp120 complex with CJF-II-197-S 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein 120, IMIDAZOLE, ... 著者 Gong, Z, Hendrickson, W.A. 登録日 2022-01-16 公開日 2023-01-25 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (3.07 Å) 主引用文献 Structural and Functional Characterization of Indane-Core CD4-Mimetic Compounds Substituted with Heterocyclic Amines ACS Medicinal Chemistry Letters, 14, 2023
4I3R	Crystal structure of the outer domain of HIV-1 gp120 in complex with VRC-PG04 space group P3221 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of VRC-PG04 Fab, Light chain of VRC-PG04 Fab, ... 著者 Joyce, M.G, Biertumpfel, C, Nabel, G.J, Kwong, P.D. 登録日 2012-11-26 公開日 2013-01-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04. J.Virol., 87, 2013
4I3S	Crystal structure of the outer domain of HIV-1 gp120 in complex with VRC-PG04 space group P21 分子名称: CALCIUM ION, Heavy chain of VRC-PG04 Fab, Light chain of VRC-PG04 Fab, ... 著者 Joyce, M.G, Biertumpfel, C, Nabel, G.J, Kwong, P.D. 登録日 2012-11-26 公開日 2013-01-09 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04. J.Virol., 87, 2013
4I54	Crystal structure of clade A/E 93TH057 HIV-1 gp120 H375S core in complex with DMJ-II-121 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HIV-1 glycoprotein, ... 著者 Le-Khac, M, Hendrickson, W.A. 登録日 2012-11-28 公開日 2013-05-29 最終更新日 2021-05-26 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization. ACS Med Chem Lett, 4, 2013
7UGQ	Cryo-EM structure of BG24 Fabs with an inferred germline CDRL1 and 10-1074 Fabs in complex with HIV-1 Env 6405-SOSIP.664 分子名称: 10-1074 Fab heavy chain, 10-1074 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Dam, K.A, Bjorkman, P.J. 登録日 2022-03-25 公開日 2022-11-09 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 HIV-1 CD4-binding site germline antibody-Env structures inform vaccine design. Nat Commun, 13, 2022
4I53	Crystal structure of clade C1086 HIV-1 gp120 core in complex with DMJ-II-121 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, FORMIC ACID, HIV-1 glycoprotein, ... 著者 Le-Khac, M, Hendrickson, W.A. 登録日 2012-11-28 公開日 2013-05-29 最終更新日 2021-05-26 実験手法 X-RAY DIFFRACTION (2.5002 Å) 主引用文献 Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization. ACS Med Chem Lett, 4, 2013
4JAN	crystal structure of broadly neutralizing antibody CH103 in complex with HIV-1 gp120 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIGEN BINDING FRAGMENT OF HEAVY CHAIN of CH103, ANTIGEN BINDING FRAGMENT OF LIGHT CHAIN of CH103, ... 著者 Zhou, T, Moquin, S, Zheng, A, Srivatsan, S, Kwong, P.D. 登録日 2013-02-18 公開日 2013-04-03 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature, 496, 2013
4JPW	Crystal structure of broadly and potently neutralizing antibody 12a21 in complex with hiv-1 strain 93th057 gp120 mutant 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HEAVY CHAIN OF ANTIBODY 12A21, ... 著者 Acharya, P, Luongo, T, Zhou, T, Kwong, P.D. 登録日 2013-03-19 公開日 2013-04-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.904 Å) 主引用文献 Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization. Cell(Cambridge,Mass.), 153, 2013
4JKP	Restricting HIV-1 Pathways for Escape using Rationally-Designed Anti-HIV-1 Antibodies 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of antibody 45-46M2, Light chain of antibody 45-46M2, ... 著者 Diskin, R, Bjorkman, P.J. 登録日 2013-03-11 公開日 2013-05-15 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 Restricting HIV-1 pathways for escape using rationally designed anti-HIV-1 antibodies. J.Exp.Med., 210, 2013
4JPJ	Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6 著者 Julien, J.-P, Jardine, J, Schief, W.R, Wilson, I.A. 登録日 2013-03-19 公開日 2013-04-10 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Rational HIV immunogen design to target specific germline B cell receptors. Science, 340, 2013
4JPV	Crystal structure of broadly and potently neutralizing antibody 3bnc117 in complex with hiv-1 gp120 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Zhou, T, Moquin, S, Kwong, P.D. 登録日 2013-03-19 公開日 2013-04-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.827 Å) 主引用文献 Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization. Cell(Cambridge,Mass.), 153, 2013
4DKR	Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with AWS-I-169 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HIV-1 gp120 core, ... 著者 Kwon, Y.D, LaLonde, J.M, Jones, D.M, Sun, A.W, Courter, J.R, Soeta, T, Kobayashi, T, Princiotto, A.M, Wu, X, Mascola, J, Schon, A, Freire, E, Sodroski, J, Madani, N, Smith III, A.B, Kwong, P.D. 登録日 2012-02-03 公開日 2012-05-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors. J.Med.Chem., 55, 2012
4DVV	Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with AS-I-261 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-{[(4S,5S)-5-(aminomethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl}-N'-(4-chloro-3-fluorophenyl)ethanediamide, ... 著者 Kwon, Y.D, Kwong, P.D. 登録日 2012-02-23 公開日 2013-02-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site. Plos One, 9, 2014
4DKP	Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with AWS-I-50 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-[(1S,2S)-2-amino-2,3-dihydro-1H-inden-1-yl]-N'-(4-chloro-3-fluorophenyl)ethanediamide, ... 著者 Kwon, Y.D, LaLonde, J.M, Jones, D.M, Sun, A.W, Courter, J.R, Soeta, T, Kobayashi, T, Princiotto, A.M, Wu, X, Mascola, J, Schon, A, Freire, E, Sodroski, J, Madani, N, Smith III, A.B, Kwong, P.D. 登録日 2012-02-03 公開日 2012-05-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7978 Å) 主引用文献 Structure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors. J.Med.Chem., 55, 2012
4DVT	Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with AS-II-37 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, N-(4-chloro-3-fluorophenyl)-N'-[(1S)-1,2,3,4-tetrahydroisoquinolin-1-ylmethyl]ethanediamide, ... 著者 Kwon, Y.D, Kwong, P.D. 登録日 2012-02-23 公開日 2013-02-27 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site. Plos One, 9, 2014

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