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4I3S

Crystal structure of the outer domain of HIV-1 gp120 in complex with VRC-PG04 space group P21

Summary for 4I3S
Entry DOI10.2210/pdb4i3s/pdb
Related3ngb 3se8 3se9 3tyg 4I3R
DescriptorOuter domain of HIV-1 gp120 (KER2018 OD4.2.2), Heavy chain of VRC-PG04 Fab, Light chain of VRC-PG04 Fab, ... (4 entities in total)
Functional Keywordsantibody affinity, antibody specificity, binding sites, hiv infections, antibodies, hiv envelope protein gp120, aids vaccines, amino acid sequence, antigens, epitopes, hiv antibodies, cd4, somatic mutation, sequence engineering, complementarity determining regions, immunoglobulin fab fragments, sera, viral protein-immune system complex, viral protein/immune system
Biological sourceHuman Immunodeficiency Virus
More
Total number of polymer chains3
Total formula weight68532.84
Authors
Joyce, M.G.,Biertumpfel, C.,Nabel, G.J.,Kwong, P.D. (deposition date: 2012-11-26, release date: 2013-01-09, Last modification date: 2023-12-27)
Primary citationJoyce, M.G.,Kanekiyo, M.,Xu, L.,Biertumpfel, C.,Boyington, J.C.,Moquin, S.,Shi, W.,Wu, X.,Yang, Y.,Yang, Z.Y.,Zhang, B.,Zheng, A.,Zhou, T.,Zhu, J.,Mascola, J.R.,Kwong, P.D.,Nabel, G.J.
Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04.
J.Virol., 87:2294-2306, 2013
Cited by
PubMed: 23236069
DOI: 10.1128/JVI.02717-12
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.85 Å)
Structure validation

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