4I3R
Crystal structure of the outer domain of HIV-1 gp120 in complex with VRC-PG04 space group P3221
Summary for 4I3R
Entry DOI | 10.2210/pdb4i3r/pdb |
Related | 3ngb 3se8 3se9 3tyg 4I3S |
Descriptor | Outer domain of HIV-1 gp120 (KER2018 OD4.2.2), Heavy chain of VRC-PG04 Fab, Light chain of VRC-PG04 Fab, ... (5 entities in total) |
Functional Keywords | antibody affinity, antibody specificity, binding sites, hiv infections, antibodies, hiv envelope protein gp120, aids vaccines, amino acid sequence, antigens, epitopes, hiv antibodies, cd4, somatic mutation, sequence engineering, complementarity determining regions, immunoglobulin fab fragments, sera, viral protein-immune system complex, viral protein/immune system |
Biological source | Human Immunodeficiency Virus More |
Total number of polymer chains | 3 |
Total formula weight | 69377.60 |
Authors | Joyce, M.G.,Biertumpfel, C.,Nabel, G.J.,Kwong, P.D. (deposition date: 2012-11-26, release date: 2013-01-09, Last modification date: 2023-09-20) |
Primary citation | Joyce, M.G.,Kanekiyo, M.,Xu, L.,Biertumpfel, C.,Boyington, J.C.,Moquin, S.,Shi, W.,Wu, X.,Yang, Y.,Yang, Z.Y.,Zhang, B.,Zheng, A.,Zhou, T.,Zhu, J.,Mascola, J.R.,Kwong, P.D.,Nabel, G.J. Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04. J.Virol., 87:2294-2306, 2013 Cited by PubMed: 23236069DOI: 10.1128/JVI.02717-12 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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