4JPV

Crystal structure of broadly and potently neutralizing antibody 3bnc117 in complex with hiv-1 gp120

Summary for 4JPV

• Entry DOI: 10.2210/pdb4jpv/pdb
• Related: 3NGB 3SE8 3SE9 4GW4 4JPW
• Descriptor: HIV-1 CLADE A STRAIN 93TH057 GP120 WITH LOOP d AND LOOPD V5 REPLACED FROM HIV STRAIN 3415V1, HEAVY CHAIN OF ANTIBODY 3BNC117, LIGHT CHAIN OF ANTIBODY 3BNC117, ... (7 entities in total)
• Functional Keywords: hiv, gp120, cd4-binding site, 3bnc117, neutralization, vaccine, antibody, envelope protein, viral protein-immune system complex, viral protein/immune system
• Biological source: HUMAN IMMUNODEFICIENCY VIRUS 1; More
• Total number of polymer chains: 3
• Total formula weight: 89781.44

Authors

Zhou, T.,Moquin, S.,Kwong, P.D. (deposition date: 2013-03-19, release date: 2013-04-17, Last modification date: 2023-09-20)

• Primary citation: Klein, F.,Diskin, R.,Scheid, J.F.,Gaebler, C.,Mouquet, H.,Georgiev, I.S.,Pancera, M.,Zhou, T.,Incesu, R.B.,Fu, B.Z.,Gnanapragasam, P.N.,Oliveira, T.Y.,Seaman, M.S.,Kwong, P.D.,Bjorkman, P.J.,Nussenzweig, M.C.; Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization.; Cell(Cambridge,Mass.), 153:126-138, 2013; PubMed: 23540694; DOI: 10.1016/j.cell.2013.03.018

Experimental method

X-RAY DIFFRACTION (2.827 Å)