PDB: 109 件ウェブページステータス検索Chemie searchBIRD

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6Y8M	Fragment bikinin bound to Interleukin 1 beta 分子名称: 4-[(5-bromopyridin-2-yl)amino]-4-oxobutanoic acid, Interleukin-1 beta, SULFATE ION 著者 De Nicola, G.F, Nichols, C.E. 登録日 2020-03-05 公開日 2020-03-18 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Fragment bikinin bound to Interleukin 1 beta To Be Published
2WRY	Crystal structure of chicken cytokine interleukin 1 beta 分子名称: INTERLEUKIN-1BETA 著者 Lu, W.S, Cheng, C.S, Lyu, P.C, Lee, L.H, Wang, W.C, Yin, H.S. 登録日 2009-09-03 公開日 2010-09-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Structural and Functional Comparison of Cytokine Interleukin-1 Beta from Chicken and Human. Mol.Immunol., 48, 2011
6HPI	NMR structure of the pro-inflammatory cytokine interleukin-36alpha 分子名称: Interleukin-36 alpha 著者 Ohlenschlaeger, O, Imhof, D. 登録日 2018-09-21 公開日 2019-10-02 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 (1)H, (13)C, and (15)N resonance assignments for the pro-inflammatory cytokine interleukin-36alpha. Biomol NMR Assign, 10, 2016
4HJJ	Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule 分子名称: Anti-IL12 Anti-IL18 DFab Heavy Chain, Anti-IL12 Anti-IL18 DFab Light Chain, CHLORIDE ION, ... 著者 Jakob, C.G, Edalji, R, Judge, R.A, DiGiammarino, E, Li, Y, Gu, J, Ghayur, T. 登録日 2012-10-12 公開日 2013-05-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig[TM]) molecule MAbs, 5, 2013
4I1B	FUNCTIONAL IMPLICATIONS OF INTERLEUKIN-1BETA BASED ON THE THREE-DIMENSIONAL STRUCTURE 分子名称: INTERLEUKIN-1 BETA 著者 Veerapandian, B, Poulos, T.L, Gilliland, G.L, Raag, R, Svensson, L.A, Masui, Y, Hirai, Y. 登録日 1990-03-27 公開日 1990-04-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Functional implications of interleukin-1 beta based on the three-dimensional structure. Proteins, 12, 1992
3NJ5	Crystal structure of chicken IL-1 hydrophobic cavity mutant 157 分子名称: IL-1 beta 著者 Yin, H.S, Chen, Y.W. 登録日 2010-06-17 公開日 2011-06-22 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Structural and functional comparison of cytokine interleukin-1 beta from chicken and human Mol.Immunol., 48, 2011
7CHY	Crystal Structure Of Human Il-1beta In Complex With Antibody Binding Fragment Of IgG26 分子名称: Interleukin-1 beta, heavy chain of antibody binding fragment of IgG26, light chain of antibody binding fragment of IgG26 著者 Lee, C.C, Wang, A.H.J, Kuo, W.C. 登録日 2020-07-06 公開日 2021-01-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structure-based Development of Human Interleukin-1 beta-Specific Antibody That Simultaneously Inhibits Binding to Both IL-1RI and IL-1RAcP. J.Mol.Biol., 433, 2020
4P0K	Crystal Structure of Double Loop-Swapped Interleukin-36Ra 分子名称: Interleukin-36 receptor antagonist/Interleukin-36 gamma chimera protein 著者 Guenther, S, Sundberg, E.J. 登録日 2014-02-21 公開日 2014-06-25 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor. J Immunol., 193, 2014
7CHZ	Crystal Structure Of Human Il-1beta In Complex With Antibody Binding Fragment Of IgG26A 分子名称: Interleukin-1 beta, heavy chain of antibody binding fragment of IgG26A, light chain of antibody binding fragment of IgG26A 著者 Lee, C.C, Wang, A.H.J, Kuo, W.C. 登録日 2020-07-06 公開日 2021-01-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure-based Development of Human Interleukin-1 beta-Specific Antibody That Simultaneously Inhibits Binding to Both IL-1RI and IL-1RAcP. J.Mol.Biol., 433, 2020
4P0J	Crystal Structure of Loop-Swapped Interleukin-36Ra 分子名称: Interleukin-36 receptor antagonist/Interleukin-36 gamma chimera protein 著者 Guenther, S, Sundberg, E.J. 登録日 2014-02-21 公開日 2014-06-25 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.298 Å) 主引用文献 Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor. J Immunol., 193, 2014
4P0L	Crystal Structure of Double Loop-Swapped Interleukin-36Ra With Additional Point Mutations 分子名称: Interleukin-36 receptor antagonist/Interleukin-36 gamma chimera protein 著者 Guenther, S, Sundberg, E.J. 登録日 2014-02-21 公開日 2014-06-25 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor. J Immunol., 193, 2014
4IZE	Crystal Structure of IL-36gamma 分子名称: Interleukin-36 gamma 著者 Guenther, S, Sundberg, E.J. 登録日 2013-01-29 公開日 2014-06-25 最終更新日 2014-07-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Molecular Determinants of Agonist and Antagonist Signaling through the IL-36 Receptor. J.Immunol., 193, 2014
3POK	Interleukin-1-beta LBT L3 Mutant 分子名称: Interleukin-1 beta 著者 Barthelmes, K, Reynolds, A.M, Peisach, E, Jonker, H.R.A, DeNunzio, N.J, Allen, K.N, Imperiali, B, Schwalbe, H. 登録日 2010-11-22 公開日 2011-01-19 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Engineering encodable lanthanide-binding tags into loop regions of proteins. J.Am.Chem.Soc., 133, 2011
3WO2	Crystal structure of human interleukin-18 分子名称: 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Interleukin-18, SULFATE ION 著者 Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H. 登録日 2013-12-19 公開日 2014-12-17 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.33 Å) 主引用文献 The structural basis for receptor recognition of human interleukin-18 Nat Commun, 5, 2014
3WO3	Crystal structure of IL-18 in complex with IL-18 receptor alpha 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Tsutsumi, N, Kimura, T, Arita, K, Ariyoshi, M, Ohnishi, H, Kondo, N, Shirakawa, M, Kato, Z, Tochio, H. 登録日 2013-12-19 公開日 2014-12-17 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 The structural basis for receptor recognition of human interleukin-18 Nat Commun, 5, 2014
41BI	INTERLEUKIN-1 BETA (IL-1 BETA) (MUTANT WITH CYS 8 REPLACED BY ALA (C8A) 分子名称: INTERLEUKIN-1 BETA 著者 Veerapandian, B, Poulos, T.L, Gilliland, G.L, Masui, Y, Hirai, Y. 登録日 1992-02-03 公開日 1992-04-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献
8RZB	IL-1beta in complex with covalent DEL hit 分子名称: 8-[4-methyl-3-(trifluoromethyl)phenyl]-2-[[(7S)-7-(2-morpholin-4-ylethylcarbamoyl)-4-(phenylsulfonyl)-1,4-diazepan-1-yl]carbonyl]imidazo[1,2-a]pyridine-6-carboxylic acid, Interleukin-1 beta 著者 Rondeau, J.-M, Lehmann, S. 登録日 2024-02-12 公開日 2024-05-22 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.836 Å) 主引用文献 Ligandability Assessment of IL-1 beta by Integrated Hit Identification Approaches. J.Med.Chem., 67, 2024
8RYK	IL-1beta in complex with macrocyclic peptide hit 分子名称: Interleukin-1 beta, Macrocyclic peptide 著者 Rondeau, J.-M, Lehmann, S. 登録日 2024-02-09 公開日 2024-05-22 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Ligandability Assessment of IL-1 beta by Integrated Hit Identification Approaches. J.Med.Chem., 67, 2024
8RYS	Human IL-1beta, unliganded 分子名称: Interleukin-1 beta, SULFATE ION 著者 Rondeau, J.-M, Lehmann, S. 登録日 2024-02-09 公開日 2024-03-06 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.16 Å) 主引用文献 Ligandability Assessment of IL-1 beta by Integrated Hit Identification Approaches. J.Med.Chem., 67, 2024
4G6J	Crystal structure of human IL-1beta in complex with the therapeutic antibody binding fragment of canakinumab 分子名称: Interleukin-1 beta, heavy chain of antibody binding fragment of canakinumab, light chain of antibody binding fragment of canakinumab 著者 Blech, M, Hoerer, S. 登録日 2012-07-19 公開日 2012-12-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 One traget-two different binding modes: Structural insights into gevokizumab and canakinumab interactions to interleukin-1beta J.Mol.Biol., 425, 2013
1S0L	Interleukin 1 beta mutant F42W 分子名称: Interleukin-1 beta 著者 Adamek, D.H, Guerrero, L, Caspar, D.L.D. 登録日 2003-12-31 公開日 2004-03-30 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
1T4Q	Interleukin 1 beta F101W 分子名称: Interleukin-1 beta 著者 Adamek, D.H, Guerrero, L, Caspar, D.L. 登録日 2004-04-30 公開日 2004-12-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
1TWE	INTERLEUKIN 1 BETA MUTANT F101Y 分子名称: Interleukin-1 beta 著者 Adamek, D.H, Capsar, D.L. 登録日 2004-06-30 公開日 2004-12-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
1TOO	Interleukin 1B Mutant F146W 分子名称: Interleukin-1 beta 著者 Adamek, D.H, Guerrero, L, Caspar, D.L. 登録日 2004-06-14 公開日 2004-12-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005
1TP0	Triple mutation in interleukin 1 beta cavity:replacement of phenylalanines with tryptophan. 分子名称: Interleukin-1 beta 著者 Adamek, D.H, Guerrero, L, Caspar, D.L. 登録日 2004-06-15 公開日 2005-02-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural and energetic consequences of mutations in a solvated hydrophobic cavity. J.Mol.Biol., 346, 2005

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