PDB: 334 件ウェブページステータス検索Chemie searchBIRD

---

1NJA	THYMIDYLATE SYNTHASE, MUTATION, N229C WITH 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (DCMP) 分子名称: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Finer-Moore, J, Stroud, R.M. 登録日 1996-01-23 公開日 1996-07-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. Biochemistry, 35, 1996
1NJC	THYMIDYLATE SYNTHASE, MUTATION, N229D WITH 2'-DEOXYCYTIDINE 5'-MONOPHOSPHATE (DCMP) 分子名称: 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Finer-Moore, J, Stroud, R.M. 登録日 1996-01-23 公開日 1996-07-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. Biochemistry, 35, 1996
1VZB	L. CASEI THYMIDYLATE SYNTHASE MUTANT E60Q BINARY COMPLEX WITH DUMP 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Birdsall, D.L, Finer-Moore, J, Stroud, R.M. 登録日 1996-09-18 公開日 1997-03-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis. Protein Eng., 11, 1998
1VZA	THYMIDYLATE SYNTHASE E60D MUTANT BINARY COMPLEX WITH 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Birdsall, D.L, Finer-Moore, J, Stroud, R.M. 登録日 1996-09-18 公開日 1997-03-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis. Protein Eng., 11, 1998
1VZD	L. CASEI THYMIDYLATE SYNTHASE MUTANT E60Q TERNARY COMPLEX WITH FDUMP AND CB3717 分子名称: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Birdsall, D.L, Finer-Moore, J, Stroud, R.M. 登録日 1996-09-18 公開日 1997-03-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis. Protein Eng., 11, 1998
1VZC	L. CASEI THYMIDYLATE SYNTHASE MUTANT E60Q BINARY COMPLEX WITH FDUMP 分子名称: 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Birdsall, D.L, Finer-Moore, J, Stroud, R.M. 登録日 1996-09-18 公開日 1997-03-12 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis. Protein Eng., 11, 1998
1VZE	L. CASEI THYMIDYLATE SYNTHASE MUTANT E60Q TERNARY COMPLEX WITH DUMP AND CB3717 分子名称: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Birdsall, D.L, Finer-Moore, J, Stroud, R.M. 登録日 1996-09-18 公開日 1997-03-12 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis. Protein Eng., 11, 1998
1ZPR	E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) 分子名称: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Sage, C.R, Stout, T.J, Rutenber, E.E, Stroud, R.M. 登録日 1996-10-15 公開日 1997-07-07 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q. Biochemistry, 35, 1996
1KCE	E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) 分子名称: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Sage, C.R, Rutenber, E.E, Stout, T.J, Stroud, R.M. 登録日 1996-10-22 公開日 1997-04-21 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q. Biochemistry, 35, 1996
1TSN	THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH FDUMP AND METHYLENETETRAHYDROFOLATE 分子名称: 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, PHOSPHATE ION, ... 著者 Hyatt, D.C, Maley, F, Montfort, W.R. 登録日 1996-12-02 公開日 1997-07-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate. Biochemistry, 36, 1997
1TLS	THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH FDUMP AND METHYLENETETRAHYDROFOLATE 分子名称: 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, THYMIDYLATE SYNTHASE 著者 Hyatt, D.C, Maley, F, Montfort, W.R. 登録日 1996-12-03 公開日 1997-07-07 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate. Biochemistry, 36, 1997
2TDM	STRUCTURE OF THYMIDYLATE SYNTHASE 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Finer-Moore, J, Stroud, R.M. 登録日 1997-03-28 公開日 1997-08-20 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. J.Mol.Biol., 232, 1993
1AIQ	CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE R126E MUTANT 分子名称: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Strop, P, Montfort, W.R. 登録日 1997-04-23 公開日 1997-11-12 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structures of a marginally active thymidylate synthase mutant, Arg 126-->Glu. Protein Sci., 6, 1997
1AJM	CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE R126E MUTANT 分子名称: THYMIDYLATE SYNTHASE 著者 Strop, P, Montfort, W.R. 登録日 1997-05-06 公開日 1997-11-12 最終更新日 2021-11-03 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structures of a marginally active thymidylate synthase mutant, Arg 126-->Glu. Protein Sci., 6, 1997
2KCE	BINDING OF THE ANTICANCER DRUG ZD1694 TO E. COLI THYMIDYLATE SYNTHASE: ASSESSING SPECIFICITY AND AFFINITY 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE, TOMUDEX 著者 Rutenber, E.E, Stroud, R.M. 登録日 1997-06-09 公開日 1997-11-19 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Binding of the anticancer drug ZD1694 to E. coli thymidylate synthase: assessing specificity and affinity. Structure, 4, 1996
1TSL	L. CASEI THYMIDYLATE SYNTHASE WITH SPECIES SPECIFIC INHIBITOR 分子名称: 3'-3"-DICHLOROPHENOL-1,8-3H-BENZO[DE]ISOCHROMEN-1-ONE, PHOSPHATE ION, THYMIDYLATE SYNTHASE 著者 Stout, T.J, Stroud, R.M. 登録日 1997-06-12 公開日 1998-06-17 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure-based design of inhibitors specific for bacterial thymidylate synthase. Biochemistry, 38, 1999
1TSM	L. CASEI THYMIDYLATE SYNTHASE WITH SPECIES SPECIFIC INHIBITOR 分子名称: 3-DIPHENOL-6-NITRO-3H-BENZO[DE]ISOCHROMEN-1-ONE, PHOSPHATE ION, THYMIDYLATE SYNTHASE 著者 Stout, T.J, Stroud, R.M. 登録日 1997-06-12 公開日 1998-06-17 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure-based design of inhibitors specific for bacterial thymidylate synthase. Biochemistry, 38, 1999
1TDU	E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE (DURD) 分子名称: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE, PHOSPHATE ION, ... 著者 Stout, T.J, Sage, C.R, Stroud, R.M. 登録日 1997-06-25 公開日 1998-07-01 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The additivity of substrate fragments in enzyme-ligand binding. Structure, 6, 1998
1AN5	E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717 分子名称: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, PHOSPHATE ION, THYMIDYLATE SYNTHASE 著者 Stout, T.J, Sage, C.R, Stroud, R.M. 登録日 1997-06-26 公開日 1998-07-01 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The additivity of substrate fragments in enzyme-ligand binding. Structure, 6, 1998
1DDU	E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717 AND 2',5'-DIDEOXYURIDINE (DDURD) 分子名称: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-5'DIDEOXYURIDINE, PHOSPHATE ION, ... 著者 Stout, T.J, Sage, C.R, Stroud, R.M. 登録日 1997-06-26 公開日 1998-07-01 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The additivity of substrate fragments in enzyme-ligand binding. Structure, 6, 1998
1TJS	E. COLI THYMIDYLATE SYNTHASE 分子名称: PHOSPHATE ION, THYMIDYLATE SYNTHASE 著者 Stout, T.J, Sage, C.R, Stroud, R.M. 登録日 1997-06-27 公開日 1998-07-01 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The additivity of substrate fragments in enzyme-ligand binding. Structure, 6, 1998
1BDU	E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH DURD 分子名称: 2'-DEOXYURIDINE, PHOSPHATE ION, THYMIDYLATE SYNTHASE 著者 Stout, T.J, Sage, C.R, Stroud, R.M. 登録日 1997-06-27 公開日 1998-07-01 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The additivity of substrate fragments in enzyme-ligand binding. Structure, 6, 1998
1BID	E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Stout, T.J, Sage, C.R, Stroud, R.M. 登録日 1997-06-27 公開日 1998-07-01 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 The additivity of substrate fragments in enzyme-ligand binding. Structure, 6, 1998
1AOB	E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH DDURD 分子名称: 2'-5'DIDEOXYURIDINE, FORMIC ACID, PHOSPHATE ION, ... 著者 Stout, T.J, Sage, C.R, Stroud, R.M. 登録日 1997-06-30 公開日 1998-07-01 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The additivity of substrate fragments in enzyme-ligand binding. Structure, 6, 1998
1JMH	CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN-229 MUTANTS OF THYMIDYLATE SYNTHASE 分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE 著者 Finer-Moore, J, Stroud, R.M. 登録日 1997-09-13 公開日 1998-01-28 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase. J.Mol.Biol., 276, 1998

<1234567891011121314>