1TSL
L. CASEI THYMIDYLATE SYNTHASE WITH SPECIES SPECIFIC INHIBITOR
Summary for 1TSL
Entry DOI | 10.2210/pdb1tsl/pdb |
Descriptor | THYMIDYLATE SYNTHASE, PHOSPHATE ION, 3'-3"-DICHLOROPHENOL-1,8-3H-BENZO[DE]ISOCHROMEN-1-ONE, ... (4 entities in total) |
Functional Keywords | methyltransferase, species specificity, structure-based drug design, antibiotic |
Biological source | Lactobacillus casei |
Cellular location | Cytoplasm: P00469 |
Total number of polymer chains | 1 |
Total formula weight | 37162.70 |
Authors | Stout, T.J.,Stroud, R.M. (deposition date: 1997-06-12, release date: 1998-06-17, Last modification date: 2024-05-22) |
Primary citation | Stout, T.J.,Tondi, D.,Rinaldi, M.,Barlocco, D.,Pecorari, P.,Santi, D.V.,Kuntz, I.D.,Stroud, R.M.,Shoichet, B.K.,Costi, M.P. Structure-based design of inhibitors specific for bacterial thymidylate synthase. Biochemistry, 38:1607-1617, 1999 Cited by PubMed: 9931028DOI: 10.1021/bi9815896 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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