2KCE

BINDING OF THE ANTICANCER DRUG ZD1694 TO E. COLI THYMIDYLATE SYNTHASE: ASSESSING SPECIFICITY AND AFFINITY

Summary for 2KCE

Entry DOI	10.2210/pdb2kce/pdb
Descriptor	THYMIDYLATE SYNTHASE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, TOMUDEX, ... (4 entities in total)
Functional Keywords	methyltransferase, reaction intermediate, antifolate, drug design
Biological source	Escherichia coli
Cellular location	Cytoplasm: P0A884
Total number of polymer chains	2
Total formula weight	62564.65
Authors	Rutenber, E.E.,Stroud, R.M. (deposition date: 1997-06-09, release date: 1997-11-19, Last modification date: 2012-10-10)
Primary citation	Rutenber, E.E.,Stroud, R.M. Binding of the anticancer drug ZD1694 to E. coli thymidylate synthase: assessing specificity and affinity. Structure, 4:1317-1324, 1996 Cited by PubMed: 8939755 DOI: 10.1016/S0969-2126(96)00139-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation