Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1XU2
DownloadVisualize
BU of 1xu2 by Molmil
The crystal structure of APRIL bound to BCMA
分子名称: NICKEL (II) ION, Tumor necrosis factor ligand superfamily member 13, Tumor necrosis factor receptor superfamily member 17
著者Hymowitz, S.G, Patel, D.R, Wallweber, H.J.A, Runyon, S, Yan, M, Yin, J, Shriver, S.K, Gordon, N.C, Pan, B, Skelton, N.J, Kelley, R.F, Starovasnik, M.A.
登録日2004-10-25
公開日2004-11-09
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structures of APRIL-receptor complexes: Like BCMA, TACI employs only a single cysteine-rich domain for high-affinity ligand binding
J.Biol.Chem., 280, 2005
2AZ5
DownloadVisualize
BU of 2az5 by Molmil
Crystal Structure of TNF-alpha with a small molecule inhibitor
分子名称: 6,7-DIMETHYL-3-[(METHYL{2-[METHYL({1-[3-(TRIFLUOROMETHYL)PHENYL]-1H-INDOL-3-YL}METHYL)AMINO]ETHYL}AMINO)METHYL]-4H-CHROMEN-4-ONE, Tumor necrosis factor (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) (Cachectin) [Contains: Tumor necrosis factor, membrane form; Tumor necrosis factor, ...
著者He, M.M.
登録日2005-09-09
公開日2005-11-29
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Small-molecule inhibition of TNF-alpha.
Science, 310, 2005
2E7A
DownloadVisualize
BU of 2e7a by Molmil
TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity
分子名称: Tumor necrosis factor
著者Mukai, Y, Yamagata, Y, Tsutsumi, Y.
登録日2007-01-09
公開日2007-11-13
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist
J.Biol.Chem., 283, 2008
2O0O
DownloadVisualize
BU of 2o0o by Molmil
Crystal structure of TL1A
分子名称: MAGNESIUM ION, TNF superfamily ligand TL1A
著者Jin, T.C, Kim, S, Guo, F, Howard, A.J, Zhang, Y.Z.
登録日2006-11-27
公開日2007-10-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献X-ray crystal structure of TNF ligand family member TL1A at 2.1A.
Biochem.Biophys.Res.Commun., 364, 2007
2Q8O
DownloadVisualize
BU of 2q8o by Molmil
crystal structure of mouse GITR ligand dimer
分子名称: GITR ligand
著者Zhaocai, Z, Yukiko, T.
登録日2007-06-11
公開日2007-12-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural basis for ligand-mediated mouse GITR activation.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2QDN
DownloadVisualize
BU of 2qdn by Molmil
Crystal Structure of mouse GITRL
分子名称: GITR ligand
著者Chattopadhyay, K, Ramagopal, U.A, Nathenson, S.G, Almo, S.C.
登録日2007-06-21
公開日2008-01-01
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2QE3
DownloadVisualize
BU of 2qe3 by Molmil
Crystal structure of human tl1a extracellular domain
分子名称: CHLORIDE ION, TNF superfamily ligand TL1A
著者Zhan, C, Yan, Q, Patskovsky, Y, Shi, W, Toro, R, Bonanno, J, Nathenson, S.G, Almo, S.C.
登録日2007-06-22
公開日2007-07-17
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Biochemical and structural characterization of the human TL1A ectodomain.
Biochemistry, 48, 2009
2RE9
DownloadVisualize
BU of 2re9 by Molmil
Crystal structure of TL1A at 2.1 A
分子名称: GLYCEROL, MAGNESIUM ION, TNF superfamily ligand TL1A
著者Jin, T.C, Guo, F, Kim, S, Howard, A.J, Zhang, Y.Z.
登録日2007-09-25
公開日2007-10-09
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献X-ray crystal structure of TNF ligand family member TL1A at 2.1 A.
Biochem.Biophys.Res.Commun., 364, 2007
2RJK
DownloadVisualize
BU of 2rjk by Molmil
Crystal Structure of Human TL1A Extracellular Domain C95S Mutant
分子名称: TNF superfamily ligand TL1A
著者Zhan, C, Yan, Q, Patskovsky, Y, Shi, W, Ramagopal, U.A, Toro, R, Bonanno, J, Nathenson, S.G, Almo, S.C.
登録日2007-10-15
公開日2008-08-26
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Biochemical and structural characterization of the human TL1A ectodomain.
Biochemistry, 48, 2009
2RJL
DownloadVisualize
BU of 2rjl by Molmil
Crystal structure of human TL1A extracellular domain C95S/C135S mutant
分子名称: TNF superfamily ligand TL1A
著者Zhan, C, Patskovsky, Y, Yan, Q, Shi, W, Toro, R, Bonanno, J, Nathenson, S.G, Almo, S.C.
登録日2007-10-15
公開日2008-08-26
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Biochemical and structural characterization of the human TL1A ectodomain.
Biochemistry, 48, 2009
2TNF
DownloadVisualize
BU of 2tnf by Molmil
1.4 A RESOLUTION STRUCTURE OF MOUSE TUMOR NECROSIS FACTOR, TOWARDS MODULATION OF ITS SELECTIVITY AND TRIMERISATION
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ISOPROPYL ALCOHOL, PROTEIN (TUMOR NECROSIS FACTOR ALPHA)
著者Baeyens, K.J, De Bondt, H.L, Raeymaekers, A, Fiers, W, De Ranter, C.J.
登録日1998-10-12
公開日1999-10-12
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献The structure of mouse tumour-necrosis factor at 1.4 A resolution: towards modulation of its selectivity and trimerization.
Acta Crystallogr.,Sect.D, 55, 1999
2TUN
DownloadVisualize
BU of 2tun by Molmil
CONFORMATIONAL CHANGES IN THE (ALA-84-VAL) MUTANT OF TUMOR NECROSIS FACTOR
分子名称: TUMOR NECROSIS FACTOR-ALPHA
著者Saludjian, P, Prange, T.
登録日1993-10-06
公開日1994-01-31
最終更新日2013-06-19
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Conformational Changes in the (Ala-84-Val) Mutant of Tumor Necrosis Factor
To be Published
2X29
DownloadVisualize
BU of 2x29 by Molmil
Crystal structure of human4-1BB ligand ectodomain
分子名称: TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 9
著者Won, E.Y, Cho, H.S.
登録日2010-01-12
公開日2010-03-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The Structure of the Trimer of Human 4-1Bb Ligand is Unique Among Members of the Tumor Necrosis Factor Superfamily.
J.Biol.Chem., 285, 2010
2ZJC
DownloadVisualize
BU of 2zjc by Molmil
TNFR1 selectve TNF mutant; R1-6
分子名称: GLYCEROL, Tumor necrosis factor
著者Mukai, Y, Yamagata, Y, Tsutsumi, Y.
登録日2008-03-05
公開日2009-01-20
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure-Function Relationship of Tumor Necrosis Factor (TNF) and Its Receptor Interaction Based on 3D Structural Analysis of a Fully Active TNFR1-Selective TNF Mutant
J.Mol.Biol., 385, 2009
2ZPX
DownloadVisualize
BU of 2zpx by Molmil
TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity; R1antTNF-T8
分子名称: Tumor necrosis factor
著者Mukai, Y, Nakamura, T, Yamagata, Y, Tsutsumi, Y.
登録日2008-07-29
公開日2009-03-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.83 Å)
主引用文献Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists
J.Biochem., 146, 2009
3ALQ
DownloadVisualize
BU of 3alq by Molmil
Crystal structure of TNF-TNFR2 complex
分子名称: COBALT (II) ION, Tumor necrosis factor, Tumor necrosis factor receptor superfamily member 1B
著者Mukai, Y, Nakamura, T, Yamagata, Y, Tsutsumi, Y.
登録日2010-08-06
公開日2010-11-17
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Solution of the Structure of the TNF-TNFR2 Complex
Sci.Signal., 3, 2010
3B9I
DownloadVisualize
BU of 3b9i by Molmil
Crystal Structure of mouse GITRL at 2.5 A.
分子名称: GITR ligand
著者Chattopadhyay, K, Ramagopal, U.A, Nathenson, S.G, Almo, S.C.
登録日2007-11-05
公開日2008-01-01
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3FC0
DownloadVisualize
BU of 3fc0 by Molmil
1.8 A crystal structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells
分子名称: ACETATE ION, GITR ligand
著者Chattopadhyay, K, Ramagopal, U.A, Nathenson, S.G, Almo, S.C.
登録日2008-11-20
公開日2008-12-30
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells.
Acta Crystallogr.,Sect.D, 65, 2009
3IT8
DownloadVisualize
BU of 3it8 by Molmil
Crystal structure of TNF alpha complexed with a poxvirus MHC-related TNF binding protein
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2L protein, Tumor necrosis factor
著者Yang, Z, West Jr, A.P, Bjorkman, P.J.
登録日2009-08-27
公開日2009-10-20
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of TNFalpha complexed with a poxvirus MHC-related TNF binding protein
Nat.Struct.Mol.Biol., 16, 2009
3K48
DownloadVisualize
BU of 3k48 by Molmil
Crystal structure of APRIL bound to a peptide
分子名称: Tumor necrosis factor ligand superfamily member 13, peptide
著者Hymowitz, S.G.
登録日2009-10-05
公開日2009-11-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Multiple novel classes of APRIL-specific receptor-blocking peptides isolated by phage display.
J.Mol.Biol., 396, 2010
3K51
DownloadVisualize
BU of 3k51 by Molmil
Crystal Structure of DcR3-TL1A complex
分子名称: Decoy receptor 3, Tumor necrosis factor ligand superfamily member 15, secreted form
著者Zhan, C, Patskovsky, Y, Yan, Q, Li, Z, Ramagopal, U.A, Nathenson, S.G, Almo, S.C.
登録日2009-10-06
公開日2010-10-13
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Decoy Strategies: The Structure of TL1A:DcR3 Complex.
Structure, 19, 2011
3L9J
DownloadVisualize
BU of 3l9j by Molmil
Selection of a novel highly specific TNFalpha antagonist: Insight from the crystal structure of the antagonist-TNFalpha complex
分子名称: MAGNESIUM ION, TNFalpha, Tumor necrosis factor, ...
著者Byla, P, Andersen, M.H, Thogersen, H.C, Gad, H.H, Hartmann, R.
登録日2010-01-05
公開日2010-02-23
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Selection of a novel and highly specific TNF{alpha} antagonist: insight from the crystal structure of the antagonist-TNF{alpha} complex
J.Biol.Chem., 285, 2010
3LKJ
DownloadVisualize
BU of 3lkj by Molmil
Small Molecule Inhibition of the TNF Family Cyokine CD40 Ligand Through a Subunit Fracture Mechanism
分子名称: (2R)-{[(2'-[(biphenyl-3-ylmethyl)carbamoyl]-6'-{[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-6-{[(2R)-2-(1H-pyrrol-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-4,4'-bipyridin-2-yl)carbonyl]amino}(cyclohexyl)ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CD40 ligand
著者Silvian, L.F, Whitty, A.
登録日2010-01-27
公開日2011-02-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism.
Acs Chem.Biol., 6, 2011
3ME2
DownloadVisualize
BU of 3me2 by Molmil
Crystal structure of mouse RANKL-RANK complex
分子名称: CHLORIDE ION, SODIUM ION, Tumor necrosis factor ligand superfamily member 11, ...
著者Walter, S.W, Liu, C.Z, Zhu, X.K, Wu, Y, Owens, R.J, Stuart, D.I, Gao, B, Ren, J.
登録日2010-03-31
公開日2010-06-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural and Functional Insights of RANKL-RANK Interaction and Signaling.
J.Immunol., 2010
3MI8
DownloadVisualize
BU of 3mi8 by Molmil
The structure of TL1A-DCR3 COMPLEX
分子名称: TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 15, SECRETED FORM, Tumor necrosis factor receptor superfamily member 6B
著者Zhan, C, Patskovsky, Y, Yan, Q, Li, Z, Ramagopal, U.A, Nathenson, S.G, Almo, S.C.
登録日2010-04-09
公開日2011-02-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.951 Å)
主引用文献Decoy Strategies: The Structure of TL1A:DcR3 Complex.
Structure, 19, 2011

221051

件を2024-06-12に公開中

PDB statisticsPDBj update infoContact PDBjnumon