1FSZ
 
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3N2G
 | | TUBULIN-NSC 613863: RB3 Stathmin-like domain complex | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Barbier, P, Dorleans, A, Devred, F, Sanz, L, Allegro, D, Alfonso, C, Knossow, M, Peyrot, V, Andreu, J.M. | | 登録日 | 2010-05-18 | | 公開日 | 2010-07-28 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (4 Å) | | 主引用文献 | Stathmin and interfacial microtubule inhibitors recognize a naturally curved conformation of tubulin dimers.
J.Biol.Chem., 285, 2010
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1JFF
 | | Refined structure of alpha-beta tubulin from zinc-induced sheets stabilized with taxol | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Lowe, J, Li, H, Downing, K.H, Nogales, E. | | 登録日 | 2001-06-20 | | 公開日 | 2001-09-19 | | 最終更新日 | 2023-08-16 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (3.5 Å) | | 主引用文献 | Refined structure of alpha beta-tubulin at 3.5 A resolution.
J.Mol.Biol., 313, 2001
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4TV9
 | | Tubulin-PM060184 complex | | 分子名称: | (1Z,4S,6Z)-1-[(N-{(2Z,4Z,6E,8S)-8-[(2S)-5-methoxy-6-oxo-3,6-dihydro-2H-pyran-2-yl]-6-methylnona-2,4,6-trienoyl}-3-methy l-L-valyl)amino]octa-1,6-dien-4-yl carbamate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Prota, A.E, Bargsten, K, Diaz, J.F, Marsh, M, Cuevas, C, Liniger, M, Neuhaus, C, Andreu, J.M, Altmann, K.H, Steinmetz, M.O. | | 登録日 | 2014-06-26 | | 公開日 | 2014-08-20 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4TUY
 | | Tubulin-Rhizoxin complex | | 分子名称: | (1R,2R,3E,5R,7R,8S,10S,13E,16R)-8-hydroxy-10-[(2S,3R,4E,6E,8E)-3-methoxy-4,8-dimethyl-9-(2-methyl-1,3-oxazol-4-yl)nona-4,6,8-trien-2-yl]-2,7-dimethyl-6,11,19-trioxatricyclo[14.3.1.0~5,7~]icosa-3,13-diene-12,18-dione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Prota, A.E, Bargsten, K, Diaz, J.F, Marsh, M, Cuevas, C, Liniger, M, Neuhaus, C, Andreu, J.M, Altmann, K.H, Steinmetz, M.O. | | 登録日 | 2014-06-25 | | 公開日 | 2014-08-27 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs.
Proc.Natl.Acad.Sci.USA, 111, 2014
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3RYI
 | | GDP-Tubulin: rb3 stathmin-like domain complex | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Nawrotek, A, Knossow, M, Gigant, B. | | 登録日 | 2011-05-11 | | 公開日 | 2011-10-05 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The Determinants That Govern Microtubule Assembly from the Atomic Structure of GTP-Tubulin.
J.Mol.Biol., 412, 2011
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3RYC
 | | Tubulin: RB3 stathmin-like domain complex | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Nawrotek, A, Knossow, M, Gigant, B. | | 登録日 | 2011-05-11 | | 公開日 | 2011-10-05 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The Determinants That Govern Microtubule Assembly from the Atomic Structure of GTP-Tubulin.
J.Mol.Biol., 412, 2011
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8I7O
 | | In situ structure of axonemal doublet microtubules in mouse sperm with 16-nm repeat | | 分子名称: | Cilia and flagella-associated protein 77, Cilia- and flagella-associated protein 20, Cilia- and flagella-associated protein 276, ... | | 著者 | Zhu, Y, Yin, G.L, Tai, L.H, Sun, F. | | 登録日 | 2023-02-01 | | 公開日 | 2023-10-11 | | 最終更新日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | In-cell structural insight into the stability of sperm microtubule doublet.
Cell Discov, 9, 2023
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8I7R
 | | In situ structure of axonemal doublet microtubules in mouse sperm with 48-nm repeat | | 分子名称: | Cilia and flagella-associated protein 77, Cilia- and flagella-associated protein 107, Cilia- and flagella-associated protein 141, ... | | 著者 | Zhu, Y, Yin, G.L, Tai, L.H, Sun, F. | | 登録日 | 2023-02-02 | | 公開日 | 2023-10-11 | | 最終更新日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | | 主引用文献 | In-cell structural insight into the stability of sperm microtubule doublet.
Cell Discov, 9, 2023
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8HUH
 | | Crystal structure of T2R-TTL-3a complex | | 分子名称: | 2-(1-methylindol-4-yl)-4-(3,4,5-trimethoxyphenyl)-1~{H}-imidazo[4,5-c]pyridine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Wang, Y.X, Chen, J.J. | | 登録日 | 2022-12-23 | | 公開日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of T2R-TTL-3a complex
To Be Published
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6PC4
 | | Tubulin-RB3_SLD-TTL in complex with compound ABI-274 | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Kumar, G, Wang, Y, Li, W, White, S.W. | | 登録日 | 2019-06-15 | | 公開日 | 2020-04-22 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | | 主引用文献 | Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties.
J.Med.Chem., 63, 2020
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6O61
 | | Tubulin-RB3_SLD-TTL in complex with compound ABI-231 | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Kumar, G, Wang, Y, Li, W, White, S.W. | | 登録日 | 2019-03-05 | | 公開日 | 2019-07-10 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.599 Å) | | 主引用文献 | Structure-Guided Design, Synthesis, and Biological Evaluation of (2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231) Analogues Targeting the Colchicine Binding Site in Tubulin.
J.Med.Chem., 62, 2019
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6OJQ
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2VAP
 | | FtsZ GDP M. jannaschii | | 分子名称: | CELL DIVISION PROTEIN FTSZ HOMOLOG 1, GUANOSINE-5'-DIPHOSPHATE | | 著者 | Oliva, M.A, Lowe, J. | | 登録日 | 2007-09-03 | | 公開日 | 2007-09-11 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural Insights Into the Conformational Variability of Ftsz
J.Mol.Biol., 373, 2007
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6E7B
 | | 13-pf 3-start GMPCPP-human alpha1B/beta3 microtubules | | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | | 著者 | Ti, S.C, Alushin, G.M, Kapoor, T.M. | | 登録日 | 2018-07-25 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Human beta-Tubulin Isotypes Can Regulate Microtubule Protofilament Number and Stability.
Dev. Cell, 47, 2018
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8RIZ
 | | Microtubule-associated kinesin-1 tail complex bound to ADP, two-headed state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Atherton, J, Chegkazi, M.S, Steiner, R.A. | | 登録日 | 2023-12-19 | | 公開日 | 2024-11-20 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that is unaffected by its autoinhibitory tail
Biorxiv, 2024
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3DCO
 | | Drosophila NOD (3DC4) and Bovine Tubulin (1JFF) Docked into the 11-Angstrom Cryo-EM Map of Nucleotide-Free NOD Complexed to the Microtubule | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Bovine Alpha Tubulin, Bovine Beta Tubulin, ... | | 著者 | Sindelar, C.V, Cochran, J.C, Kull, F.J. | | 登録日 | 2008-06-04 | | 公開日 | 2009-02-10 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (11 Å) | | 主引用文献 | ATPase cycle of the nonmotile kinesin NOD allows microtubule end tracking and drives chromosome movement.
Cell(Cambridge,Mass.), 136, 2009
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8RIV
 | | T2R-TTL-1-K08 complex | | 分子名称: | (4-fluoranyl-2-methyl-1~{H}-indol-5-yl) 3,4,5-trimethoxybenzenesulfonate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Boiarska, Z, Homer, J.A, Steinmetz, M.O, Moses, J.E, Prota, A.E.P. | | 登録日 | 2023-12-19 | | 公開日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | | 主引用文献 | Modular synthesis of functional libraries by accelerated SuFEx click chemistry.
Chem Sci, 15, 2024
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8RIW
 | | T2R-TTL-1-L01 complex | | 分子名称: | (2-methyl-1~{H}-indol-5-yl) 3,4,5-trimethoxybenzenesulfonate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Prota, A.E.P, Boiarska, Z, Homer, J.A, Steinmetz, M.O, Moses, J.E. | | 登録日 | 2023-12-19 | | 公開日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Modular synthesis of functional libraries by accelerated SuFEx click chemistry.
Chem Sci, 15, 2024
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8RC1
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6EG5
 | | The structure of SB-1-202-tubulin complex | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-chloropyrido[2,3-d]pyrimidin-4-yl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one, CALCIUM ION, ... | | 著者 | Banerjee, A.K, Wang, Y, Chen, H, Miller, D, Li, W. | | 登録日 | 2018-08-18 | | 公開日 | 2019-08-21 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | The structure of SB-1-202/SB-2-204-tubulin complex
To Be Published
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6EW0
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3DU7
 | | Tubulin-colchicine-phomopsin A: Stathmin-like domain complex | | 分子名称: | 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Cormier, A, Marchand, M, Ravelli, R.B, Knossow, M, Gigant, B. | | 登録日 | 2008-07-17 | | 公開日 | 2008-10-21 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (4.1 Å) | | 主引用文献 | Structural insight into the inhibition of tubulin by vinca domain peptide ligands
Embo Rep., 9, 2008
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6EVZ
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3E22
 | | Tubulin-colchicine-soblidotin: Stathmin-like domain complex | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Cormier, A, Marchand, M, Ravelli, R.B, Knossow, M, Gigant, B. | | 登録日 | 2008-08-05 | | 公開日 | 2008-10-21 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Structural insight into the inhibition of tubulin by vinca domain peptide ligands
Embo Rep., 9, 2008
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