4TUY

Tubulin-Rhizoxin complex

Summary for 4TUY

Entry DOI	10.2210/pdb4tuy/pdb
Related	4I4T 4I50 4I55 4IHJ 4IIJ 4O2A 4O2B 4O4H 4O4I 4O4J 4O4L
Descriptor	Tubulin alpha-1B chain, (1R,2R,3E,5R,7R,8S,10S,13E,16R)-8-hydroxy-10-[(2S,3R,4E,6E,8E)-3-methoxy-4,8-dimethyl-9-(2-methyl-1,3-oxazol-4-yl)nona-4,6,8-trien-2-yl]-2,7-dimethyl-6,11,19-trioxatricyclo[14.3.1.0~5,7~]icosa-3,13-diene-12,18-dione, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
Functional Keywords	cell cycle, cytoskeleton, tubulin fold, rhizoxin
Biological source	Rattus norvegicus (Rat) More
Cellular location	Cytoplasm, cytoskeleton: P81947 Cytoplasm, cytoskeleton (By similarity): Q6B856 Golgi apparatus: P63043
Total number of polymer chains	6
Total formula weight	265075.96
Authors	Prota, A.E.,Bargsten, K.,Diaz, J.F.,Marsh, M.,Cuevas, C.,Liniger, M.,Neuhaus, C.,Andreu, J.M.,Altmann, K.H.,Steinmetz, M.O. (deposition date: 2014-06-25, release date: 2014-08-27, Last modification date: 2023-12-20)
Primary citation	Prota, A.E.,Bargsten, K.,Diaz, J.F.,Marsh, M.,Cuevas, C.,Liniger, M.,Neuhaus, C.,Andreu, J.M.,Altmann, K.H.,Steinmetz, M.O. A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs. Proc.Natl.Acad.Sci.USA, 111:13817-13821, 2014 Cited by PubMed: 25114240 DOI: 10.1073/pnas.1408124111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation