PDB: 672 件ウェブページステータス検索Chemie searchBIRD

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2I0C	Crystal structure of the GluR6 ligand binding core dimer crosslinked by disulfide bonds between Y490C and L752C at 2.25 Angstroms Resolution 分子名称: GLUTAMIC ACID, Glutamate receptor, ionotropic kainate 2 著者 Mayer, M.L. 登録日 2006-08-10 公開日 2006-11-21 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Conformational restriction blocks glutamate receptor desensitization. Nat.Struct.Mol.Biol., 13, 2006
2I3W	Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of S729C mutant 分子名称: GLUTAMATE RECEPTOR SUBUNIT 2, GLUTAMIC ACID 著者 Armstrong, N, Jasti, J, Beich-Frandsen, M, Gouaux, E. 登録日 2006-08-21 公開日 2006-10-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor. Cell(Cambridge,Mass.), 127, 2006
4X48	Crystal structure of GluR2 ligand-binding core 分子名称: GLUTAMIC ACID, Glutamate receptor 2, N-{(3S,4S)-4-[4-(5-cyanothiophen-2-yl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide, ... 著者 Pandit, J. 登録日 2014-12-02 公開日 2015-05-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 The Discovery and Characterization of the alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N-{(3S,4S)-4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242). J.Med.Chem., 58, 2015
4WXJ	Drosophila muscle GluRIIB complex with glutamate 分子名称: GLUTAMIC ACID, Glutamate receptor IIB,Glutamate receptor IIB 著者 Dharkar, P, Mayer, M.L. 登録日 2014-11-13 公開日 2015-04-29 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.002 Å) 主引用文献 Functional reconstitution of Drosophila melanogaster NMJ glutamate receptors. Proc.Natl.Acad.Sci.USA, 112, 2015
4QF9	Structure of GluK1 ligand-binding domain (S1S2) in complex with (S)-2-amino-4-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-6-yl)butanoic acid at 2.28 A resolution 分子名称: (2S)-2-amino-4-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-6-yl)butanoic acid, ACETATE ION, CHLORIDE ION, ... 著者 Kristensen, C.M, Frydenvang, K, Kastrup, J.S. 登録日 2014-05-20 公開日 2015-04-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Binding Mode of an alpha-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1. ACS Chem Neurosci, 6, 2015
7OCC	NTD of resting state GluA1/A2 heterotertramer 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor 1, ... 著者 Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H. 登録日 2021-04-26 公開日 2021-06-09 最終更新日 2021-06-30 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Gating and modulation of a hetero-octameric AMPA glutamate receptor. Nature, 594, 2021
7OCA	Resting state full-length GluA1/A2 heterotertramer in complex with TARP gamma 8 and CNIH2 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H. 登録日 2021-04-26 公開日 2021-06-09 最終更新日 2021-06-30 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Gating and modulation of a hetero-octameric AMPA glutamate receptor. Nature, 594, 2021
7OCD	Resting state GluA1/A2 heterotetramer in complex with auxiliary subunit TARP gamma 8 (LBD-TMD) 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, Glutamate receptor 2, ... 著者 Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H. 登録日 2021-04-26 公開日 2021-06-09 最終更新日 2021-06-30 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Gating and modulation of a hetero-octameric AMPA glutamate receptor. Nature, 594, 2021
7OCE	Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD) 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide, CHOLESTEROL, ... 著者 Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H. 登録日 2021-04-26 公開日 2021-06-09 最終更新日 2021-06-30 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Gating and modulation of a hetero-octameric AMPA glutamate receptor. Nature, 594, 2021
7OCF	Active state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD) 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CYCLOTHIAZIDE, GLUTAMIC ACID, ... 著者 Zhang, D, Watson, J.F, Matthews, P.M, Cais, O, Greger, I.H. 登録日 2021-04-26 公開日 2021-06-09 最終更新日 2021-06-30 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Gating and modulation of a hetero-octameric AMPA glutamate receptor. Nature, 594, 2021
2PBW	Crystal Structure of the Ligand-Binding Core of iGluR5 in Complex with the Partial agonist Domoic Acid at 2.5 A Resolution 分子名称: (2S,3S,4S)-2-CARBOXY-4-[(1Z,3E,5R)-5-CARBOXY-1-METHYL-1,3-HEXADIENYL]-3-PYRROLIDINEACETIC ACID, Glutamate receptor, ionotropic kainate 1 著者 Hald, H, Naur, P, Gajhede, M, Kastrup, J.S. 登録日 2007-03-29 公開日 2007-07-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid. J.Biol.Chem., 282, 2007
4YMA	Structure of the ligand-binding domain of GluA2 in complex with the antagonist CNG10109 分子名称: (3R)-3-(3-carboxy-5-hydroxyphenyl)-L-proline, 1,2-ETHANEDIOL, ACETATE ION, ... 著者 Moller, C, Tapken, D, Kastrup, J.S, Frydenvang, K. 登録日 2015-03-06 公開日 2015-08-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.895 Å) 主引用文献 Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid. J.Med.Chem., 58, 2015
4YMB	Structure of the ligand-binding domain of GluK1 in complex with the antagonist CNG10111 分子名称: (3R,4S)-3-(3-carboxyphenyl)-4-propyl-L-proline, 1,2-ETHANEDIOL, ACETATE ION, ... 著者 Moller, C, Tapken, D, Kastrup, J.S, Frydenvang, K. 登録日 2015-03-06 公開日 2015-08-05 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid. J.Med.Chem., 58, 2015
2OJT	Structure and mechanism of kainate receptor modulation by anions 分子名称: (S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHENE-3-YL-METHYL)-5-METHYLPYRIMIDINE-2,4-DIONE, BROMIDE ION, Glutamate receptor, ... 著者 Mayer, M.L. 登録日 2007-01-14 公開日 2007-04-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure and mechanism of kainate receptor modulation by anions. Neuron, 53, 2007
4YU0	Crystal structure of a tetramer of GluA2 TR mutant ligand binding domains bound with glutamate at 1.26 Angstrom resolution 分子名称: DI(HYDROXYETHYL)ETHER, GLUTAMIC ACID, Glutamate receptor 2,Glutamate receptor 2, ... 著者 Chebli, M, Salazar, H, Baranovic, J, Carbone, A.L, Ghisi, V, Faelber, K, Lau, A.Y, Daumke, O, Plested, A.J.R. 登録日 2015-03-18 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 Crystal structure of the tetrameric GluA2 ligand-binding domain in complex with glutamate at 1.26 Angstroms resolution To Be Published
4PE5	Crystal Structure of GluN1a/GluN2B NMDA Receptor Ion Channel 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol, ... 著者 Karakas, E, Furukawa, H. 登録日 2014-04-22 公開日 2014-06-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.96 Å) 主引用文献 Crystal structure of a heterotetrameric NMDA receptor ion channel. Science, 344, 2014
2P2A	X-ray structure of the GluR2 ligand binding core (S1S2J) in complex with 2-Bn-tet-AMPA at 2.26A resolution 分子名称: 2-AMINO-3-[3-HYDROXY-5-(2-BENZYL-2H-5-TETRAZOLYL)-4-ISOXAZOLYL]-PROPIONIC ACID, GLUTAMIC ACID, Glutamate receptor 2, ... 著者 Frydenvang, K, Kastrup, J.S, Gajhede, M. 登録日 2007-03-07 公開日 2007-06-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 A tetrazolyl-substituted subtype-selective AMPA receptor agonist. J.Med.Chem., 50, 2007
4Q30	Nitrowillardiine bound to the ligand binding domain of GluA2 at pH 3.5 分子名称: 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2 CHIMERIC PROTEIN, ZINC ION 著者 Ahmed, A.H, Oswald, R.E. 登録日 2014-04-10 公開日 2014-06-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Thermodynamics and mechanism of the interaction of willardiine partial agonists with a glutamate receptor: implications for drug development. Biochemistry, 53, 2014
4TLL	Crystal structure of GluN1/GluN2B NMDA receptor, structure 1 分子名称: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ... 著者 Gouaux, E, Lee, C.-H, Lu, W. 登録日 2014-05-30 公開日 2014-07-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.59 Å) 主引用文献 NMDA receptor structures reveal subunit arrangement and pore architecture. Nature, 511, 2014
4TLM	Crystal structure of GluN1/GluN2B NMDA receptor, structure 2 分子名称: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ... 著者 Gouaux, E, Lee, C.-H, Lu, W. 登録日 2014-05-30 公開日 2014-07-02 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.77 Å) 主引用文献 NMDA receptor structures reveal subunit arrangement and pore architecture. Nature, 511, 2014
2QS4	Crystal structure of the GluR5 ligand binding core dimer in complex with LY466195 at 1.58 Angstroms resolution 分子名称: (3S,4aR,6S,8aR)-6-{[(2S)-2-carboxy-4,4-difluoropyrrolidin-1-yl]methyl}decahydroisoquinoline-3-carboxylic acid, AMMONIUM ION, GLYCEROL, ... 著者 Alushin, G.M, Jane, D.E, Mayer, M.L. 登録日 2007-07-30 公開日 2008-08-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists. Neuropharmacology, 60, 2011
2QS1	Crystal structure of the GluR5 ligand binding core dimer in complex with UBP315 at 1.80 Angstroms resolution 分子名称: 3-({3-[(2S)-2-amino-2-carboxyethyl]-5-methyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)-4,5-dibromothiophene-2-carboxylic acid, CHLORIDE ION, Glutamate receptor, ... 著者 Alushin, G.M, Jane, D.E, Mayer, M.L. 登録日 2007-07-30 公開日 2008-08-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists. Neuropharmacology, 60, 2011
2XXU	Crystal structure of the GluK2 (GluR6) M770K LBD dimer in complex with glutamate 分子名称: CHLORIDE ION, GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2, ... 著者 Nayeem, N, Mayans, O, Green, T. 登録日 2010-11-12 公開日 2011-02-09 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Conformational Flexibility of the Ligand-Binding Domain Dimer in Kainate Receptor Gating and Desensitization J.Neurosci., 31, 2011
2XXX	Crystal structure of the GluK2 (GluR6) D776K LBD dimer in complex with glutamate (P21 21 21) 分子名称: GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2, GLUTAMIC ACID 著者 Nayeem, N, Mayans, O, Green, T. 登録日 2010-11-12 公開日 2011-02-09 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.098 Å) 主引用文献 Conformational Flexibility of the Ligand-Binding Domain Dimer in Kainate Receptor Gating and Desensitization J.Neurosci., 31, 2011
2XXT	Crystal structure of the GluK2 (GluR6) wild-type LBD dimer in complex with kainate 分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, CHLORIDE ION, GLUTAMATE RECEPTOR, ... 著者 Nayeem, N, Mayans, O, Green, T. 登録日 2010-11-12 公開日 2011-02-09 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Conformational Flexibility of the Ligand-Binding Domain Dimer in Kainate Receptor Gating and Desensitization J.Neurosci., 31, 2011

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