4QF9

Structure of GluK1 ligand-binding domain (S1S2) in complex with (S)-2-amino-4-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-6-yl)butanoic acid at 2.28 A resolution

Summary for 4QF9

Entry DOI	10.2210/pdb4qf9/pdb
Descriptor	Glutamate receptor ionotropic, kainate 1, (2S)-2-amino-4-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-6-yl)butanoic acid, SULFATE ION, ... (8 entities in total)
Functional Keywords	kainate receptor ligand-binding domain, gluk1-s1s2, antagonist, membrane protein
Biological source	Rattus norvegicus (brown rat,rat,rats) More
Cellular location	Cell membrane; Multi-pass membrane protein: P22756
Total number of polymer chains	3
Total formula weight	89258.59
Authors	Kristensen, C.M.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2014-05-20, release date: 2015-04-22, Last modification date: 2023-09-20)
Primary citation	Demmer, C.S.,Moller, C.,Brown, P.M.,Han, L.,Pickering, D.S.,Nielsen, B.,Bowie, D.,Frydenvang, K.,Kastrup, J.S.,Bunch, L. Binding Mode of an alpha-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1. ACS Chem Neurosci, 6:845-854, 2015 Cited by PubMed: 25856736 DOI: 10.1021/acschemneuro.5b00038 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.28 Å)

Structure validation