4QF9

Structure of GluK1 ligand-binding domain (S1S2) in complex with (S)-2-amino-4-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-6-yl)butanoic acid at 2.28 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 35K A 301

Chain	Residue
A	TYR16
A	HOH417
A	TYR61
A	PRO88
A	LEU89
A	THR90
A	ARG95
A	THR192
A	SER193
A	TYR216

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 302

Chain	Residue
A	GLY140
A	SER141
A	THR142
A	GLU190
A	HOH429
A	HOH453

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PG4 A 303

Chain	Residue
A	ARG31
A	LYS54
A	LEU55
A	GLU133
A	SER167
A	ARG179

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 304

Chain	Residue
A	LYS171
A	LYS171
A	ASN172
A	ASN172

---

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 35K B 301

Chain	Residue
B	GLU13
B	TYR16
B	TYR61
B	PRO88
B	LEU89
B	THR90
B	ARG95
B	THR192
B	SER193
B	TYR216
B	HOH425
B	HOH448
B	HOH449
B	HOH472

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 302

Chain	Residue
B	SER141
B	THR142
B	GLU190
B	HOH413
B	HOH462
B	HOH463
B	HOH482

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 303

Chain	Residue
A	ILE151
A	SER152
B	LYS229
B	HOH429

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 304

Chain	Residue
B	ASP212
B	HIS244
B	HOH456

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL B 305

Chain	Residue
B	ARG31
B	LEU55

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 306

Chain	Residue
B	ARG179
B	HOH438
C	ARG31
C	HOH441

---

site_id	BC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PG4 B 307

Chain	Residue
B	GLU96
B	GLU96
B	PHE101
B	PHE101
B	SER102
B	LYS103
B	LYS103
B	ARG227
B	ARG227
B	ASP228
B	ASP228
B	THR231
B	THR231

---

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 35K C 301

Chain	Residue
C	GLU13
C	GLU14
C	TYR16
C	TYR61
C	PRO88
C	THR90
C	ARG95
C	THR192
C	TYR216

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 302

Chain	Residue
C	VAL137
C	GLY140
C	SER141
C	THR142
C	MET189
C	GLU190

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT C 303

Chain	Residue
A	SER213
C	HIS244
C	HOH432

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING:

Chain	Residue	Details
A	PRO88
A	SER141
B	PRO88
B	SER141
C	PRO88
C	SER141

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:15710405, ECO:0000269|PubMed:15721240

Chain	Residue	Details
B	GLU190
C	ARG95
C	GLU190
A	ARG95
A	GLU190
B	ARG95

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000255

Chain	Residue	Details
A	SER162
B	SER162
C	SER162

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000255

Chain	Residue	Details
A	THR198
B	THR198
C	THR198

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
A	ASN203
B	ASN3
B	ASN203
C	ASN3
C	ASN203

---