4YMB

Structure of the ligand-binding domain of GluK1 in complex with the antagonist CNG10111

Summary for 4YMB

• Entry DOI: 10.2210/pdb4ymb/pdb
• Related: 4E0X
• Descriptor: Glutamate receptor ionotropic, kainate 1,Glutamate receptor ionotropic, kainate 1, (3R,4S)-3-(3-carboxyphenyl)-4-propyl-L-proline, ACETATE ION, ... (7 entities in total)
• Functional Keywords: ionotropic glutamate receptor, kainate receptor gluk1, ligand-binding domain, antagonist, signaling protein, fusion protein
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P22756
• Total number of polymer chains: 2
• Total formula weight: 59317.71

Authors

Moller, C.,Tapken, D.,Kastrup, J.S.,Frydenvang, K. (deposition date: 2015-03-06, release date: 2015-08-05, Last modification date: 2024-01-10)

• Primary citation: Krogsgaard-Larsen, N.,Storgaard, M.,Moller, C.,Demmer, C.S.,Hansen, J.,Han, L.,Monrad, R.N.,Nielsen, B.,Tapken, D.,Pickering, D.S.,Kastrup, J.S.,Frydenvang, K.,Bunch, L.; Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid.; J.Med.Chem., 58:6131-6150, 2015; PubMed: 26200741; DOI: 10.1021/acs.jmedchem.5b00750

Experimental method

X-RAY DIFFRACTION (1.93 Å)