4YMB
Structure of the ligand-binding domain of GluK1 in complex with the antagonist CNG10111
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glutamate receptor ionotropic, kainate 1,Glutamate receptor ionotropic, kainate 1 | polymer | 257 | 29108.5 | 2 | UniProt (P22756) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Rat) | GluK1,Glutamate receptor 5,GluR5,GluK1,Glutamate receptor 5,GluR5 |
| 2 | C, I (A, B) | (3R,4S)-3-(3-carboxyphenyl)-4-propyl-L-proline | non-polymer | 277.3 | 2 | Chemie (4E7) | |||
| 3 | D, J, K, L (A, B) | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) | |||
| 4 | E, F, G, M (A, B) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 5 | H (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 6 | N (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 7 | O, P (A, B) | water | water | 18.0 | 488 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 116 (UniProt: P22756)
A, B: 119 - 257 (UniProt: P22756)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Gly 34 | Ala 477 | variant |
| PDB | External Database | Details |
|---|---|---|
| Gly 117 | - | linker |
| Thr 118 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58216.9 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1100.8 | |
| All* | Total formula weight | 59317.7 |
