PDB: 438 件ウェブページステータス検索Chemie searchBIRD

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4CXN	Crystal structure of human insulin analogue (NMe-AlaB8)-insulin crystal form I 分子名称: INSULIN A CHAIN, INSULIN B CHAIN 著者 Kosinova, L, Veverka, V, Novotna, P, Collinsova, M, Urbanova, M, Jiracek, J, Moody, N.R, Turkenburg, J.P, Brzozowski, A.M, Zakova, L. 登録日 2014-04-07 公開日 2014-05-28 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin. Biochemistry, 53, 2014
4XC4	Insulin co-crystallizes in the presence of it beta-cell chaperone sulfatide 分子名称: CHLORIDE ION, Insulin, SODIUM ION, ... 著者 Bracey, A.W, Magis, A.T, Buschard, K, Osterbye, T, Bailey, K.M, Ostrov, D.A. 登録日 2014-12-17 公開日 2015-02-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.499 Å) 主引用文献 Insulin co-crystallizes in the presence of it beta-cell chaperone sulfatide To Be Published
4CY7	Crystal structure of human insulin analogue (NMe-AlaB8)-insulin crystal form II 分子名称: ACETATE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... 著者 Kosinova, L, Veverka, V, Novotna, P, Collinsova, M, Urbanova, M, Jiracek, J, Moody, N.R, Turkenburg, J.P, Brzozowski, A.M, Zakova, L. 登録日 2014-04-10 公開日 2014-05-28 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An Insight Into Structural and Biological Relevance of the T/R Transition of the B-Chain N-Terminus in Human Insulin. Biochemistry, 53, 2014
5EN9	High resolution x-ray crystal structure of isotope-labeled ester-insulin 分子名称: Insulin chain A, Insulin chain B 著者 Mandal, K, Dhayalan, B, Avital-Shmilovici, M, Tokmakoff, A, Kent, S.B.H. 登録日 2015-11-09 公開日 2016-01-13 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystallization of Enantiomerically Pure Proteins from Quasi-Racemic Mixtures: Structure Determination by X-Ray Diffraction of Isotope-Labeled Ester Insulin and Human Insulin. Chembiochem, 17, 2016
4M4I	Radiation damage study of Cu T6-insulin - 0.12 MGy 分子名称: COPPER (II) ION, Insulin 著者 Frankaer, C.G, Harris, P, Stahl, K. 登録日 2013-08-07 公開日 2014-01-15 最終更新日 2018-03-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Towards accurate structural characterization of metal centres in protein crystals: the structures of Ni and Cu T6 bovine insulin derivatives. Acta Crystallogr.,Sect.D, 70, 2014
5EMS	Crystal Structure of an iodinated insulin analog 分子名称: CHLORIDE ION, Insulin, PHENOL, ... 著者 Lawrence, M.C, Pandyarajan, V, Wan, Z, Weiss, M.A. 登録日 2015-11-06 公開日 2016-11-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Extending Halogen-based Medicinal Chemistry to Proteins: IODO-INSULIN AS A CASE STUDY. J. Biol. Chem., 291, 2016
7INS	STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z 分子名称: GENERAL PROTAMINE CHAIN, INSULIN (CHAIN A), INSULIN (CHAIN B), ... 著者 Balschmidt, P, Hansen, F.B, Dodson, E, Dodson, G, Korber, F. 登録日 1991-09-03 公開日 1994-01-31 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of porcine insulin cocrystallized with clupeine Z. Acta Crystallogr.,Sect.B, 47, 1991
7JP3	Des-B29,B30-insulin 分子名称: CHLORIDE ION, Insulin B chain,Insulin A chain, PHENOL, ... 著者 Yoder, J, Weiss, M.A, DiMarchi, R, Zaykov, A. 登録日 2020-08-07 公開日 2021-10-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Des-B29,B30-insulin To Be Published
7NHU	Crystal structure of desB30 insulin produced by cell free protein synthesis 分子名称: Insulin 著者 Johansson, E. 登録日 2021-02-11 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Cell free protein synthesis versus yeast expression - A comparison using insulin as a model protein. Protein Expr.Purif., 186, 2021
5AIY	R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, 'RED' SUBSTATE, AVERAGE STRUCTURE 分子名称: PHENOL, PROTEIN (INSULIN) 著者 O'Donoghue, S.I, Chang, X, Abseher, R, Nilges, M, Led, J.J. 登録日 1998-12-29 公開日 2000-02-28 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Unraveling the symmetry ambiguity in a hexamer: calculation of the R6 human insulin structure. J.Biomol.NMR, 16, 2000
6GNQ	Monoclinic crystalline form of human insulin, complexed with meta-cresol 分子名称: 1,2-ETHANEDIOL, Insulin, M-CRESOL, ... 著者 Margiolaki, I, Karavassili, F, Valmas, A, Dimarogona, M, Giannopoulou, A.E, Fili, S, Schluckebier, G, Norrman, M, Beckers, D, Fitch, A.N. 登録日 2018-05-31 公開日 2019-06-12 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Monoclinic crystalline form of human insulin, complexed with meta-cresol To Be Published
3KR3	Crystal structure of IGF-II antibody complex 分子名称: 1,2-ETHANEDIOL, Insulin-like growth factor II, antibody-Fab (heavy chain), ... 著者 Peat, T.S, Newman, J, Adams, T.E. 登録日 2009-11-17 公開日 2010-06-16 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo. Mol.Cancer Ther., 9, 2010
6KH8	Solution structure of Zn free Bovine Pancreatic Insulin in 20% acetic acid-d4 (pH 1.9) 分子名称: Insulin A Chain, Insulin B chain 著者 Bhunia, A, Ratha, B.N, Kar, R.K, Brender, J.R. 登録日 2019-07-14 公開日 2020-10-07 最終更新日 2020-11-18 実験手法 SOLUTION NMR 主引用文献 High-resolution structure of a partially folded insulin aggregation intermediate. Proteins, 88, 2020
6KH9	Solution structure of bovine insulin amyloid intermediate-1 分子名称: Insulin A chain, Insulin B chain 著者 Ratha, B.N, Kar, R.K, Brender, J.B, Bhunia, A. 登録日 2019-07-14 公開日 2020-08-12 最終更新日 2020-11-18 実験手法 SOLUTION NMR 主引用文献 High-resolution structure of a partially folded insulin aggregation intermediate. Proteins, 88, 2020
6KHA	Solution structure of bovine insulin amyloid intermediate-2 分子名称: Insulin A chain, Insulin B chain 著者 Ratha, B.N, Kar, R.K, Brender, J.B, Bhunia, A. 登録日 2019-07-14 公開日 2020-08-12 最終更新日 2020-11-18 実験手法 SOLUTION NMR 主引用文献 High-resolution structure of a partially folded insulin aggregation intermediate. Proteins, 88, 2020
3LRI	Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I 分子名称: PROTEIN (INSULIN-LIKE GROWTH FACTOR I) 著者 Laajoki, L.G, Francis, G.L, Wallace, J.C, Carver, J.A, Keniry, M.A. 登録日 1999-04-13 公開日 2000-05-23 最終更新日 2023-12-27 実験手法 SOLUTION NMR 主引用文献 Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I J.Biol.Chem., 275, 2000
4RXW	Crystal Structure of the cobalt human insulin derivative 分子名称: COBALT (II) ION, Insulin A chain, Insulin B chain 著者 Prugovecki, B, Ivetic, N, Matkovic-Calogovic, D. 登録日 2014-12-12 公開日 2015-01-21 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Crystal Structure of the cobalt human insulin derivative TO BE PUBLISHED
3JSD	Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus 分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ... 著者 Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G. 登録日 2009-09-10 公開日 2010-09-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus To be Published
3BXQ	The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition 分子名称: ZINC ION, insulin A chain, insulin B chain 著者 Wan, Z.L, Huang, K, Hu, S.Q, Whittaker, J, Weiss, M.A. 登録日 2008-01-14 公開日 2008-05-20 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition. J.Biol.Chem., 283, 2008
4UNE	Human insulin B26Phe mutant crystal structure 分子名称: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION 著者 Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M. 登録日 2014-05-28 公開日 2014-10-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex Acta Crystallogr.,Sect.D, 70, 2014
4UNG	Human insulin B26Asn mutant crystal structure 分子名称: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION 著者 Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M. 登録日 2014-05-28 公開日 2014-10-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex Acta Crystallogr.,Sect.D, 70, 2014
3KQ6	Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog 分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ... 著者 Wan, Z.L, Hu, S.Q, Whittaker, L, Phillips, N.B, Whittake, J, Ismail-Beigi, F, Weiss, M.A. 登録日 2009-11-17 公開日 2010-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot. J.Biol.Chem., 285, 2010
4UNH	Human insulin B26Gly mutant crystal structure 分子名称: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION 著者 Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M. 登録日 2014-05-28 公開日 2014-10-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex Acta Crystallogr.,Sect.D, 70, 2014
5L3L	D11 bound IGF-II 分子名称: Insulin-like growth factor II 著者 Hexnerova, R. 登録日 2016-05-23 公開日 2016-08-10 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. J.Biol.Chem., 291, 2016
5L3M	D11 bound [S39_PQ]-IGF-II 分子名称: Insulin-like growth factor II 著者 Hexnerova, R. 登録日 2016-05-23 公開日 2016-08-10 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. J.Biol.Chem., 291, 2016

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