PDB: 5495 件ウェブページステータス検索Chemie searchBIRD

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5B79	Crystal structure of DPF2 double PHD finger 分子名称: ZINC ION, Zinc finger protein ubi-d4 著者 Li, H, Xiong, X. 登録日 2016-06-05 公開日 2016-10-26 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.601 Å) 主引用文献 Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2 Nat.Chem.Biol., 12, 2016
5BNH	Crystal structure of the HLTF HIRAN domain with a ssDNA fragment 分子名称: ACETATE ION, DNA (5'-D(*(GD)P*GP*TP*G)-3'), DNA (5'-D(*(TD)P*TP*G)-3'), ... 著者 Neculai, D, Walker, J.R, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Dhe-Paganon, S. 登録日 2015-05-26 公開日 2016-05-25 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Co-crystal structure of the HLTF HIRAN domain with a ssDNA fragment To Be Published
5CS8	Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, GLYCEROL, ... 著者 Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. 登録日 2015-07-23 公開日 2016-01-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem., 59, 2016
5D0C	Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand 分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, GLYCEROL, ... 著者 Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. 登録日 2015-08-03 公開日 2016-01-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem., 59, 2016
5D3J	First bromodomain of BRD4 bound to inhibitor XD33 分子名称: 4-acetyl-N-[3-(diethylsulfamoyl)phenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4 著者 Wohlwend, D, Huegle, M. 登録日 2015-08-06 公開日 2016-01-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1). J.Med.Chem., 59, 2016
5D3R	First bromodomain of BRD4 bound to inhibitor XD42 分子名称: 4-acetyl-N-[3-(azepan-1-ylsulfonyl)phenyl]-5-methyl-3-propyl-1H-pyrrole-2-carboxamide, Bromodomain-containing protein 4 著者 Wohlwend, D, Huegle, M. 登録日 2015-08-06 公開日 2016-01-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 4-Acyl Pyrrole Derivatives Yield Novel Vectors for Designing Inhibitors of the Acetyl-Lysine Recognition Site of BRD4(1). J.Med.Chem., 59, 2016
5CTL	Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand 分子名称: Bromodomain-containing protein 4, N-(1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indol-6-yl)benzenesulfonamide 著者 Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. 登録日 2015-07-24 公開日 2016-01-13 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem., 59, 2016
5DMR	Crystal Structure of C-terminal domain of mouse eRF1 in complex with RNase H domain of RT of Moloney Murine Leukemia Virus 分子名称: Eukaryotic peptide chain release factor subunit 1, Reverse transcriptase/ribonuclease H p80 著者 Tang, X, Song, H. 登録日 2015-09-09 公開日 2016-07-06 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis of suppression of host translation termination by Moloney Murine Leukemia Virus Nat Commun, 7, 2016
5DLQ	Crystal structure of RanGTP-Exportin 4-eIF5A complex 分子名称: Eukaryotic translation initiation factor 5A-1, Exportin-4, GTP-binding nuclear protein Ran, ... 著者 Aksu, M, Trakhanov, S, Gorlich, D. 登録日 2015-09-07 公開日 2016-06-22 最終更新日 2016-06-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structure of the exportin Xpo4 in complex with RanGTP and the hypusine-containing translation factor eIF5A. Nat Commun, 7, 2016
5DX4	Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand 分子名称: 1,2-ETHANEDIOL, 5-bromo-N-(1-ethyl-2-oxo-1,2-dihydrobenzo[cd]indol-6-yl)-2-methoxybenzenesulfonamide, Bromodomain-containing protein 4, ... 著者 Zhang, Y, Song, M, Liu, Z, Xue, X, Xu, Y. 登録日 2015-09-23 公開日 2016-01-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation J.Med.Chem., 59, 2016
5DYG	Structure of p97 N-D1 L198W mutant in complex with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase 著者 Tang, W.K, Xia, D. 登録日 2015-09-24 公開日 2016-02-10 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain. Sci Rep, 6, 2016
5B1M	The mouse nucleosome structure containing H3.1 分子名称: DNA (146-MER), Histone H2A type 1, Histone H2B type 3-A, ... 著者 Urahama, T, Machida, S, Horikoshi, N, Osakabe, A, Tachiwana, H, Taguchi, H, Kurumizaka, H. 登録日 2015-12-08 公開日 2017-02-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis Cell Rep, 18, 2017
5BPW	Atomic-resolution structures of the APC/C subunits Apc4 and the Apc5 N-terminal domain 分子名称: Anaphase-promoting complex subunit 4 著者 Kulkarni, K, Yang, J, Zhang, Z, Barford, D. 登録日 2015-05-28 公開日 2015-09-02 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain. J.Mol.Biol., 427, 2015
5DLX	FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR N-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-1-{3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl}piperidine-4-carboxamide 分子名称: Bromodomain-containing protein 4, N-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-1-(3-methyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidine-4-carboxamide 著者 Raux, B, Rebuffet, E, Betzi, S, Morelli, X. 登録日 2015-09-07 公開日 2016-06-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery. Acs Chem.Biol., 11, 2016
5E7I	Crystal structure of the active catalytic core of the human DEAD-box protein DDX3 分子名称: ATP-dependent RNA helicase DDX3X 著者 Floor, S.N, Condon, K.J, Doudna, J.A. 登録日 2015-10-12 公開日 2015-12-02 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.223 Å) 主引用文献 Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3. J.Biol.Chem., 291, 2016
5E0U	Human PCNA variant (S228I) complexed with p21 at 1.9 Angstroms 分子名称: Cyclin-dependent kinase inhibitor 1, Proliferating cell nuclear antigen 著者 Duffy, C.M, Hilbert, B.J, Kelch, B.A. 登録日 2015-09-29 公開日 2016-04-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site. J.Mol.Biol., 428, 2016
5E7D	Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand 分子名称: (2E)-3-(dimethylamino)-1-(2-hydroxyphenyl)prop-2-en-1-one, 1,2-ETHANEDIOL, Protein polybromo-1 著者 Filippakopoulos, P, Picaud, S, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Owen, D, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2015-10-12 公開日 2016-10-12 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Crystal Structure of the fifth bromodomain of human PB1 in complex with a hydroxyphenyl ligand To Be Published
5C1A	p97-N750D/R753D/M757D/Q760D in complex with ATP-gamma-S 分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase 著者 Haenzelmann, P, Schindelin, H. 登録日 2015-06-13 公開日 2016-01-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Structural Basis of ATP Hydrolysis and Intersubunit Signaling in the AAA+ ATPase p97. Structure, 24, 2016
5CJ2	Ran GDP Y39A mutant triclinic crystal form 分子名称: GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Vetter, I.R, Brucker, S. 登録日 2015-07-13 公開日 2015-09-09 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Catalysis of GTP Hydrolysis by Small GTPases at Atomic Detail by Integration of X-ray Crystallography, Experimental, and Theoretical IR Spectroscopy. J.Biol.Chem., 290, 2015
5CLQ	Ran Y39A in complex with GPPNHP and RanBD1 分子名称: E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... 著者 Vetter, I.R, Brucker, S. 登録日 2015-07-16 公開日 2015-09-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Catalysis of GTP Hydrolysis by Small GTPases at Atomic Detail by Integration of X-ray Crystallography, Experimental, and Theoretical IR Spectroscopy. J.Biol.Chem., 290, 2015
5DLZ	FIRST DOMAIN OF HUMAN BROMODOMAIN BRD4 IN COMPLEX WITH INHIBITOR 4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]-N-({1-[(3-methylphe methyl]piperidin-4-yl}methyl)butanamide 分子名称: Bromodomain-containing protein 4, N-{[1-(3-methylbenzyl)piperidin-4-yl]methyl}-4-[(1-methyl-2-oxo-1,2-dihydroquinolin-4-yl)oxy]butanamide 著者 Raux, B, Rebuffet, E, Betzi, S, Morelli, X. 登録日 2015-09-07 公開日 2016-06-01 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery. Acs Chem.Biol., 11, 2016
5DMQ	Crystal structure of mouse eRF1 in complex with Reverse Transcriptase (RT) of Moloney Murine Leukemia Virus 分子名称: Eukaryotic peptide chain release factor subunit 1, Reverse transcriptase/ribonuclease H p80 著者 Tang, T, Song, H. 登録日 2015-09-09 公開日 2016-07-06 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Structural basis of suppression of host translation termination by Moloney Murine Leukemia Virus Nat Commun, 7, 2016
5E0V	Human PCNA variant (S228I) complexed with FEN1 at 2.1 Angstroms 分子名称: Flap endonuclease 1, Proliferating cell nuclear antigen 著者 Duffy, C.M, Hilbert, B.J, Kelch, B.A. 登録日 2015-09-29 公開日 2016-04-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.074 Å) 主引用文献 A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site. J.Mol.Biol., 428, 2016
5DNR	Aurora A Kinase in complex with ATP in space group P41212 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Aurora kinase A, MAGNESIUM ION, ... 著者 Janecek, M, Rossmann, M, Sharma, P, Emery, A, McKenzie, G, Huggins, D, Stockwell, S, Stokes, J.A, Almeida, E.G, Hardwick, B, Narvaez, A.J, Hyvonen, M, Spring, D.R, Venkitaraman, A. 登録日 2015-09-10 公開日 2016-07-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. Sci Rep, 6, 2016
5DR6	Aurora A Kinase in Complex with AA30 and JNJ-7706621 in Space Group P6122 分子名称: 2-(3-bromophenyl)quinoline-4-carboxylic acid, 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide, Aurora kinase A 著者 Janecek, M, Rossmann, M, Sharma, P, Emery, A, McKenzie, G.J, Huggins, D.J, Stockwell, S, Stokes, J.A, Almeida, E.G, Hardwick, B, Narvaez, A.J, Hyvonen, M, Spring, D.R, Venkitaraman, A.R. 登録日 2015-09-15 公開日 2016-07-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.534 Å) 主引用文献 Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. Sci Rep, 6, 2016

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