PDB: 496 件ウェブページステータス検索Chemie searchBIRD

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3EQH	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with U0126, ADP and MG2P 分子名称: (2Z)-bis{amino[(2-aminophenyl)sulfanyl]methylidene}butanedinitrile, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... 著者 Fischmann, T.O. 登録日 2008-09-30 公開日 2009-02-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48, 2009
3EQG	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with PD, ADP AND MG2P 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Fischmann, T.O. 登録日 2008-09-30 公開日 2009-02-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48, 2009
3EQF	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with K252A and MG2P 分子名称: CALCIUM ION, Dual specificity mitogen-activated protein kinase kinase 1, K-252A, ... 著者 Fischmann, T.O. 登録日 2008-09-30 公開日 2009-02-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48, 2009
3EQD	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with ATP-GS and MG2P 分子名称: CALCIUM ION, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... 著者 Fischmann, T.O. 登録日 2008-09-30 公開日 2009-02-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48, 2009
3EQC	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with compound 1, ATP-GS AND MG2P 分子名称: 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide, CALCIUM ION, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Fischmann, T.O. 登録日 2008-09-30 公開日 2009-02-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48, 2009
3EQB	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... 著者 Ohren, J.F, Pavlovsky, A, Zhang, E. 登録日 2008-09-30 公開日 2008-11-11 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.62 Å) 主引用文献 2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase). Bioorg.Med.Chem.Lett., 18, 2008
3E8N	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) complexed with a potent inhibitor RDEA119 and MgATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... 著者 Yan, S, Wang, Z.M. 登録日 2008-08-20 公開日 2009-09-01 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer. Cancer Res., 69, 2009
3DY7	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP 分子名称: (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Ohren, J.F, Pavlovsky, A, Zhang, E. 登録日 2008-07-25 公開日 2009-06-16 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK? Bioorg.Med.Chem.Lett., 19, 2009
3DV3	MEK1 with PF-04622664 Bound 分子名称: 3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-5-[(2-hydroxyethoxy)methyl]benzamide, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Kazmirski, S.L, Kothe, M, Ding, Y.-H. 登録日 2008-07-18 公開日 2009-07-21 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK? Bioorg.Med.Chem.Lett., 19, 2009
3DIK	Pseudo-atomic model of the HIV-1 CA hexameric lattice 分子名称: Capsid protein p24 著者 Ganser-Pornillos, B.K, Cheng, A, Yeager, M. 登録日 2008-06-20 公開日 2008-09-16 最終更新日 2024-02-21 実験手法 ELECTRON CRYSTALLOGRAPHY (9 Å) 主引用文献 Structure of full-length HIV-1 CA: a model for the mature capsid lattice Cell(Cambridge,Mass.), 131, 2007
2Z7L	Unphosphorylated Mitogen Activated Protein Kinase ERK2 in Complex with (4-{[5-Carbamoyl-4-(3-Methylanilino)Pyrimidin 2-Yl]Amino}Phenyl)Acetic Acid 分子名称: BETA-MERCAPTOETHANOL, Mitogen-activated protein kinase 1, SULFATE ION, ... 著者 Katayama, N, Kurihara, H. 登録日 2007-08-27 公開日 2008-08-12 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors Proteins, 73, 2008
2Y4I	KSR2-MEK1 heterodimer 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1, ... 著者 Brennan, D.F, Barford, D. 登録日 2011-01-06 公開日 2011-01-19 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.46 Å) 主引用文献 A Raf-Induced Allosteric Transition of Ksr Stimulates Ksr and Raf Phosphorylation of Mek Nature, 472, 2011
2XDE	Crystal structure of the complex of PF-3450074 with an engineered HIV capsid N terminal domain 分子名称: GAG POLYPROTEIN, N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE 著者 Brown, D.G, Irving, S.L, Anderson, M, Bazin, R. 登録日 2010-04-30 公開日 2010-12-22 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention. Plos Pathog., 6, 2010
2X2D	acetyl-CypA:HIV-1 N-term capsid domain complex 分子名称: CAPSID PROTEIN P24, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A 著者 Lammers, M, Neumann, H, Chin, J.W, James, L.C. 登録日 2010-01-12 公開日 2010-03-23 最終更新日 2018-01-24 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Acetylation Regulates Cyclophilin a Catalysis, Immunosuppression and HIV Isomerisation Nat.Chem.Biol., 6, 2010
2WLV	Structure of the N-terminal capsid domain of HIV-2 分子名称: GAG POLYPROTEIN 著者 Price, A.J, Marzetta, F, Lammers, M, Ylinen, L.M.J, Schaller, T, Wilson, S.J, Towers, G.J, James, L.C. 登録日 2009-06-26 公開日 2009-09-22 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Active Site Remodelling Switches HIV Specificity of Antiretroviral Trimcyp Nat.Struct.Mol.Biol., 16, 2009
2PXR	Crystal Structure of HIV-1 CA146 in the Presence of CAP-1 分子名称: CHLORIDE ION, Gag-Pol polyprotein (Pr160Gag-Pol), ZINC ION 著者 Kelly, B.N. 登録日 2007-05-14 公開日 2007-09-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol., 373, 2007
2PWO	Crystal Structure of HIV-1 CA146 A92E Psuedo Cell 分子名称: CHLORIDE ION, Gag-Pol polyprotein (Pr160Gag-Pol) 著者 Kelly, B.N. 登録日 2007-05-11 公開日 2007-09-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol., 373, 2007
2PWM	Crystal Structure of HIV-1 CA146 A92E real cell 分子名称: CHLORIDE ION, Gag-Pol polyprotein 著者 Kelly, B.N. 登録日 2007-05-11 公開日 2007-09-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol., 373, 2007
2P55	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP 分子名称: 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Ohren, J.F, Pavlovsky, A.G. 登録日 2007-03-14 公開日 2007-10-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase. J.Med.Chem., 50, 2007
2OJJ	Crystal structure of ERK2 in complex with (S)-N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide 分子名称: (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE, Mitogen-activated protein kinase 1, SULFATE ION 著者 Xie, X, Jacobs, M.D. 登録日 2007-01-12 公開日 2007-02-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50, 2007
2OJI	Crystal structure of ERK2 in complex with N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide 分子名称: Mitogen-activated protein kinase 1, N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE, SULFATE ION 著者 Xie, X, Jacobs, M.D. 登録日 2007-01-12 公開日 2007-02-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50, 2007
2OJG	Crystal structure of ERK2 in complex with N,N-dimethyl-4-(4-phenyl-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide 分子名称: Mitogen-activated protein kinase 1, N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE, SULFATE ION 著者 Xie, X, Jacobs, M.D. 登録日 2007-01-12 公開日 2007-02-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50, 2007
2M8P	The structure of the W184AM185A mutant of the HIV-1 capsid protein 分子名称: Capsid protein p24 著者 Deshmukh, L, Schwieters, C.D, Grishaev, A, Clore, G, Ghirlando, R. 登録日 2013-05-24 公開日 2013-11-20 最終更新日 2023-06-14 実験手法 SOLUTION NMR, SOLUTION SCATTERING 主引用文献 Structure and Dynamics of Full-Length HIV-1 Capsid Protein in Solution. J.Am.Chem.Soc., 135, 2013
2M8N	HIV-1 capsid monomer structure 分子名称: Capsid protein p24 著者 Deshmukh, L, Schwieters, C.D, Grishaev, A, Clore, G, Ghirlando, R. 登録日 2013-05-24 公開日 2013-11-20 最終更新日 2023-06-14 実験手法 SOLUTION NMR, SOLUTION SCATTERING 主引用文献 Structure and Dynamics of Full-Length HIV-1 Capsid Protein in Solution. J.Am.Chem.Soc., 135, 2013
2M8L	HIV capsid dimer structure 分子名称: Capsid protein p24 著者 Deshmukh, L, Schwieters, C.D, Grishaev, A, Clore, G, Ghirlando, R. 登録日 2013-05-23 公開日 2013-11-20 最終更新日 2023-06-14 実験手法 SOLUTION NMR, SOLUTION SCATTERING 主引用文献 Structure and Dynamics of Full-Length HIV-1 Capsid Protein in Solution. J.Am.Chem.Soc., 135, 2013

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