5N64
Crystal Structure of p38alpha in Complex with Lipid Pocket Ligand 9g
Summary for 5N64
| Entry DOI | 10.2210/pdb5n64/pdb |
| Descriptor | Mitogen-activated protein kinase 14, 2-phenyl-~{N}4-(thiophen-2-ylmethyl)quinazoline-4,7-diamine (3 entities in total) |
| Functional Keywords | kinase, small molecule, lipid pocket, p38, quinazoline, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 41675.62 |
| Authors | Buehrmann, M.,Mueller, M.P.,Wiedemann, B.,Rauh, D. (deposition date: 2017-02-14, release date: 2017-09-20, Last modification date: 2024-01-17) |
| Primary citation | Buhrmann, M.,Wiedemann, B.M.,Muller, M.P.,Hardick, J.,Ecke, M.,Rauh, D. Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38 alpha MAPK. PLoS ONE, 12:e0184627-e0184627, 2017 Cited by PubMed: 28892510DOI: 10.1371/journal.pone.0184627 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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