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5NHJ

Human Erk2 with an Erk1/2 inhibitor

Summary for 5NHJ
Entry DOI10.2210/pdb5nhj/pdb
DescriptorMitogen-activated protein kinase 1, SULFATE ION, 5-(2-methoxyethyl)-2-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one, ... (4 entities in total)
Functional Keywordserk2, kinase, inhibitor, oncology, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm, cytoskeleton, spindle : P28482
Total number of polymer chains1
Total formula weight44468.83
Authors
Primary citationWard, R.A.,Bethel, P.,Cook, C.,Davies, E.,Debreczeni, J.E.,Fairley, G.,Feron, L.,Flemington, V.,Graham, M.A.,Greenwood, R.,Griffin, N.,Hanson, L.,Hopcroft, P.,Howard, T.D.,Hudson, J.,James, M.,Jones, C.D.,Jones, C.R.,Lamont, S.,Lewis, R.,Lindsay, N.,Roberts, K.,Simpson, I.,St-Gallay, S.,Swallow, S.,Tang, J.,Tonge, M.,Wang, Z.,Zhai, B.
Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.
J. Med. Chem., 60:3438-3450, 2017
Cited by
PubMed: 28376306
DOI: 10.1021/acs.jmedchem.7b00267
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.12 Å)
Structure validation

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